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Gene · 3745

KCNB1: potassium voltage-gated channel subfamily B member 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. KCNB1: potassium voltage-gated channel subfamily B member 1. Genes, record 3745. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3745

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Gene

Symbol
KCNB1
HGNC
Name
potassium voltage-gated channel subfamily B member 1
HGNC
NCBI Gene ID
3745
NCBI Gene
HGNC ID
HGNC:6231
HGNC
Ensembl
ENSG00000158445
NCBI Gene
Aliases
DEE26, DRK1, Kv2.1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q14721Potassium voltage-gated channel subfamily B member 18586Ensembl, GeneID, HGNC

Source UniProt

Patents31

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1458754Q14721Espacenet
EP 4641201 A22025-10-299245Q14721Espacenet
JP 2025529142 A2025-09-042195Q14721Espacenet
US 12371689 B22025-07-292195Q14721Espacenet
JP 2025517969 A2025-06-129245Q14721Espacenet
US 11673916 B22023-06-1341Q14721Espacenet
US 11446398 B22022-09-2065827Q14721Espacenet
US 11446398 B22022-09-2065828Q14721Espacenet
US 11400116 B22022-08-023182Q14721Espacenet
JP 2022524081 A2022-04-27168798Q14721Espacenet

1 to 10 of 31

See all 31 patents

Drugs7

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AMIFAMPRIDINECHEMBL354077Voltage-gated potassium channel blockerBLOCKERChEMBL
AMIFAMPRIDINE PHOSPHATECHEMBL3301611Voltage-gated potassium channel blockerBLOCKERChEMBL
DALFAMPRIDINECHEMBL284348Voltage-gated potassium channel blockerBLOCKERChEMBL
GUANIDINECHEMBL821Voltage-gated potassium channel blockerBLOCKERChEMBL
GUANIDINE HYDROCHLORIDECHEMBL1200728Voltage-gated potassium channel blockerBLOCKERChEMBL
NERISPIRDINECHEMBL2107762Voltage-gated potassium channel blockerBLOCKERChEMBL
TEDISAMILCHEMBL113461Voltage-gated potassium channel blockerBLOCKERChEMBL

Trials86

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07532460DALFAMPRIDINEClinicalTrials.gov
NCT07185347DALFAMPRIDINEPHASE3ClinicalTrials.gov
NCT07171203DALFAMPRIDINEPHASE1ClinicalTrials.gov
NCT06853015DALFAMPRIDINEPHASE1/PHASE2ClinicalTrials.gov
NCT06751784DALFAMPRIDINEPHASE2ClinicalTrials.gov
NCT06596434DALFAMPRIDINEPHASE2ClinicalTrials.gov
NCT06333171DALFAMPRIDINEPHASE2ClinicalTrials.gov
NCT06294821DALFAMPRIDINEPHASE2ClinicalTrials.gov
NCT06136728DALFAMPRIDINEPHASE3ClinicalTrials.gov
NCT05919407AMIFAMPRIDINEPHASE3ClinicalTrials.gov

1 to 10 of 86

See all 86 trials

NIH grants1,129

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleKCNB1 papersNewest fiscal year
T32HL086350Training Program in Basic and Translational Cardiovascular Science62025
ZIANS002945Gating mechanisms and pharmacology of voltage-activated ion channels62025
U24NS109113Molecularly Defined Immunoprobes for Scalable Brain Protein Mapping with Reference Datasets42025
R01GM030376The Electrophysiological Studies of Voltage Gated Channels32025
R01NS107671Therapeutic small molecule modulation of Kv channels32025
U24NS120854ClinGen Expert Curation Panel for the Epilepsies32025
UL1TR001878Institutional Clinical and Translational Science Award32025
P30CA012197Cancer Center Support Grant22025
P30CA068485Cancer Center Support Grant22025
P30EY003176UC Berkeley Vision Science CORE22025

1 to 10 of 1,129Source NIH's project files

See all 1,129 nih grants

Papers1,741

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Modulation of voltage-dependent K+ channel activity by the muscarinic receptor antagonist solifenacin in native coronary arterial smooth muscle cells.Korean J Physiol Pharmacol202642733228PubTator, text miningPubMed
Epileptic encephalopathy-related Kv2.1 mutants impair clustering but not neuronal excitability.Biophys J202642717490PubTator, text miningPubMed
Tunable Chemical and Optical Modulation of ER-Plasma Membrane Contact-Site Geometry, Dynamics, and Protein Recruitment with High-Fidelity Visualization.Anal Chem202642674029PubTator, text miningPubMed
Urinary proteomic signature of exercise intolerance in patients at risk of heart failure: evidence from the HOMAGE trial.EBioMedicine202642531722PubTator, text miningPubMed
Building structure activity relationships to avoid toxicity due to unwanted central nervous system ion channel activity.Toxicol Sci202642530889PubTator, text miningPubMed
Electrophysiological Characterization of MK886-Mediated Suppression of Voltage-Gated K+ Currents in Rabbit Coronary Artery Smooth Muscle Cells.J Appl Toxicol202642487466PubTator, text miningPubMed
Ancestry-informative regulatory variants at KCNB1 modulate adipogenesis and body mass index.Front Endocrinol (Lausanne)202642181176PubTator, text miningPubMed
Unveiling sleep disturbances in KCNB1-related disorders: Insights from a cohort of 78 individuals.Epilepsia Open202642166541PubTator, text miningPubMed
Distinct mechanisms of inhibition of Kv2 potassium channels by tetraethylammonium and RY785.Elife202642043292PubTator, text miningPubMed
Potassium Channelopathies and Precision Medicine Approaches in Epilepsy: A Systematic Review of Personalized Treatment Strategies.Curr Neuropharmacol202642003125PubTator, text miningPubMed

1 to 10 of 1,741

See all 1,741 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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