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Gene · 3752

KCND3: potassium voltage-gated channel subfamily D member 3

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. KCND3: potassium voltage-gated channel subfamily D member 3. Genes, record 3752. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3752

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Gene

Symbol
KCND3
HGNC
Name
potassium voltage-gated channel subfamily D member 3
HGNC
NCBI Gene ID
3752
NCBI Gene
HGNC ID
HGNC:6239
HGNC
Ensembl
ENSG00000171385
NCBI Gene
Aliases
BRGDA9, KCND3L, KCND3S, KSHIVB, KV4.3, Kv4.3, SCA19, SCA22
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9UK17A-type voltage-gated potassium channel KCND36556Ensembl, GeneID, HGNC

Source UniProt

Patents36

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1458784Q9UK17Espacenet
EP 4650780 A22025-11-195257Q9UK17Espacenet
EP 4641201 A22025-10-294845Q9UK17Espacenet
JP 2025529142 A2025-09-042201Q9UK17Espacenet
US 12371689 B22025-07-292201Q9UK17Espacenet
JP 2025517969 A2025-06-124845Q9UK17Espacenet
JP 2025517970 A2025-06-125257Q9UK17Espacenet
JP 2025032204 A2025-03-1130265Q9UK17Espacenet
EP 4461818 A22024-11-1330265Q9UK17Espacenet
JP 2023058610 A2023-04-2530265Q9UK17Espacenet

1 to 10 of 36

See all 36 patents

Drugs9

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AMIFAMPRIDINECHEMBL354077Voltage-gated potassium channel blockerBLOCKERChEMBL
AMIFAMPRIDINE PHOSPHATECHEMBL3301611Voltage-gated potassium channel blockerBLOCKERChEMBL
DALFAMPRIDINECHEMBL284348Voltage-gated potassium channel blockerBLOCKERChEMBL
GUANIDINECHEMBL821Voltage-gated potassium channel blockerBLOCKERChEMBL
GUANIDINE HYDROCHLORIDECHEMBL1200728Voltage-gated potassium channel blockerBLOCKERChEMBL
NERISPIRDINECHEMBL2107762Voltage-gated potassium channel blockerBLOCKERChEMBL
TEDISAMILCHEMBL113461Voltage-gated potassium channel blockerBLOCKERChEMBL
VERNAKALANTCHEMBL2111112Voltage-gated potassium channel subunit Kv4.3 blockerBLOCKERChEMBL
VERNAKALANT HYDROCHLORIDECHEMBL2107383Voltage-gated potassium channel subunit Kv4.3 blockerBLOCKERChEMBL

Trials96

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07532460DALFAMPRIDINEClinicalTrials.gov
NCT07185347DALFAMPRIDINEPHASE3ClinicalTrials.gov
NCT07171203DALFAMPRIDINEPHASE1ClinicalTrials.gov
NCT06853015DALFAMPRIDINEPHASE1/PHASE2ClinicalTrials.gov
NCT06751784DALFAMPRIDINEPHASE2ClinicalTrials.gov
NCT06596434DALFAMPRIDINEPHASE2ClinicalTrials.gov
NCT06333171DALFAMPRIDINEPHASE2ClinicalTrials.gov
NCT06294821DALFAMPRIDINEPHASE2ClinicalTrials.gov
NCT06136728DALFAMPRIDINEPHASE3ClinicalTrials.gov
NCT05919407AMIFAMPRIDINEPHASE3ClinicalTrials.gov

1 to 10 of 96

See all 96 trials

NIH grants1,363

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleKCND3 papersNewest fiscal year
R01HL092577IDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVAL62025
R01HL131517Sex-specific arrhythmogenic mechanisms of atrial fibrillation42025
P40OD010440Caenorhabditis Genetics Center32025
R01HL113006Human Induced Pluripotent Stem Cells for Cardiovascular Disease Modeling32025
R01HL141214Functional Microdomains in the Heart's Pacemaker: A New Dimension of Cardiac Remodeling32025
P50AA022537Cross-species investigation of gene networks for ethanol-related behaviors22025
R01AA011147Ethanol and aldehyde dehydrogenases in health and disease22025
R01AI040127Signal transduction and gene induction in lymphocytes22025
R01HL085844Functional interactions of cardiac ion channels22025
R01HL128368Engineered Stem Cells for Cardiac Repair22025

1 to 10 of 1,363Source NIH's project files

See all 1,363 nih grants

Papers2,071

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Exploring the Potential Neurotoxic Links Between 6PPD/6PPD-Q and Parkinson's Disease Through Network Toxicology and Multi-Dimensional Bioinformatics Analysis.Neurotox Res202642821203PubTator, text miningPubMed
Selective inhibition of LY294002 across cloned human cardiac ion channels: implications for atrium-selective therapy in atrial fibrillation.Front Pharmacol202642780784PubTator, text miningPubMed
Selectivity Filter KCND3 Variant Causes Spinocerebellar Ataxia 19/22 and KV4.3 Functional Loss.Mov Disord202642712185PubTator, text miningPubMed
Annexin A4 Deficient Ventricular Myocytes Display Advanced Hypertrophy and Electrical Remodeling With Chronic β-Adrenoceptor Stimulation.FASEB J202642684683PubTator, text miningPubMed
Characterization of an early-diverging KCNE potassium-channel auxiliary subunit in the jawless vertebrate lamprey.Elife202642647063PubTator, text miningPubMed
Ceramide-Mediated Lipotoxicity: A Metabolic Driver of Myocardial Dysfunction in Heart Failure with Preserved Ejection Fraction.Curr Cardiol Rev202642509675PubTator, text miningPubMed
The interplay between dynamic regulation of ion-channel gating and trafficking in cardiac arrhythmogenesis.J Physiol202642330017PubTator, text miningPubMed
ARumenamides as Multitarget Ion Channel Modulators: Insights from Fenestration-Focused Docking, ADMET Profiling, and Molecular Dynamics.Int J Mol Sci202642278315PubTator, text miningPubMed
Activation of TREK-1 and TREK-2 Two-Pore Domain Potassium Channels by the Kv4 Channel Modulator, NS5806.Pharmacol Res Perspect202642135999PubTator, text miningPubMed
Integrative Single- and Multi-Trait GWASs Identify Pleiotropic Loci Affecting Growth and Egg Production in Zhedong Geese.Animals (Basel)202641976052PubTator, text miningPubMed

1 to 10 of 2,071

See all 2,071 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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