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Gene · 3759

KCNJ2: potassium inwardly rectifying channel subfamily J member 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. KCNJ2: potassium inwardly rectifying channel subfamily J member 2. Genes, record 3759. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3759

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Gene

Symbol
KCNJ2
HGNC
Name
potassium inwardly rectifying channel subfamily J member 2
HGNC
NCBI Gene ID
3759
NCBI Gene
HGNC ID
HGNC:6263
HGNC
Ensembl
ENSG00000123700
NCBI Gene
Aliases
ATFB9, HHBIRK1, HHIRK1, IRK1, KIR2.1, Kir2.1, LQT7, SQT3
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P63252Inward rectifier potassium channel 24273Ensembl, GeneID, HGNC

Source UniProt

Patents52

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1458668P63252Espacenet
JP 2026004568 A2026-01-1458669P63252Espacenet
JP 2025529142 A2025-09-042228P63252Espacenet
US 12371689 B22025-07-292228P63252Espacenet
KR 1020240158140 A2024-11-048P63252Espacenet
EP 4450514 A22024-10-2379P63252Espacenet
US 11980671 B22024-05-1427P63252Espacenet
JP 2024517810 A2024-04-2381P63252Espacenet
JP 2023520374 A2023-05-1740P63252Espacenet
US 11446398 B22022-09-2065658P63252Espacenet

1 to 10 of 52

See all 52 patents

Drugs2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
DRONEDARONECHEMBL184412Inward rectifier potassium channel 2 blockerBLOCKERChEMBL
DRONEDARONE HYDROCHLORIDECHEMBL1201729Inward rectifier potassium channel 2 blockerBLOCKERChEMBL

Trials25

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

NIH grants2,391

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleKCNJ2 papersNewest fiscal year
R01HL059949Structural Determinants of PIP2 Regulation172025
R01HL092577IDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVAL132025
P30DK063491Diabetes Research Center (DRC)102025
R01HL113006Human Induced Pluripotent Stem Cells for Cardiovascular Disease Modeling92025
T32HL007936Training Program in Translational Cardiovascular Science82025
R35HL140027Capillaries as a Sensory Web that Controls Cerebral Blood Flow in Health and Disease72025
T32HL007572Research Methods in Pediatric Cardiovascular Disease72025
R01DK054231Molecular of ROMK Channel Function62025
R01HL130020Elucidating Mechanism of Cardiac Fibrosis with Cell Village of Pooled Human iPSCs62025
R01HL131517Sex-specific arrhythmogenic mechanisms of atrial fibrillation62025

1 to 10 of 2,391Source NIH's project files

See all 2,391 nih grants

Papers3,420

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Two Pulses per Beat: Parallel Energetics of Myocardium and Coronary Wall.Physiology (Bethesda)202742490304PubTator, text miningPubMed
Brain endothelial homeostasis in psychiatric disorders: mechanisms, evidence, and translational opportunities.Front Cell Neurosci202642819782PubTator, text miningPubMed
Targeting the miR-3156-3p/K+ channel axis suppresses viral release and paralysis in enterovirus D68 infection.Mol Ther202642817166PubTator, text miningPubMed
Genetic loci responsible for atrioventricular block in children.Front Cell Dev Biol202642798645PubTator, text miningPubMed
Selective inhibition of LY294002 across cloned human cardiac ion channels: implications for atrium-selective therapy in atrial fibrillation.Front Pharmacol202642780784PubTator, text miningPubMed
Perfluorooctanoic acid-associated complement factor B upregulation and atrial fibrillation-related molecular alterations: integrated network toxicology, Mendelian randomization, molecular dynamics, and HL-1 cell analyses.
Front Cardiovasc Med202642755451PubTator, text miningPubMed
Diagnostic and therapeutic challenges in Andersen-Tawil syndrome.Heart Rhythm202642754000PubTator, text miningPubMed
Impaired clinical, biological, and cytokine patterns in HIV-1 exposed uninfected newborns in Yaoundé: A comparative study of neonatal immune vulnerability.Afr J Lab Med202642698915PubTator, text miningPubMed
Membrane Potential Hyperpolarization Controls the Osteogenic Differentiation of Human Dental Follicle Stem Cells by Increasing Intracellular Ca2+ Levels.Front Biosci (Landmark Ed)202642689977PubTator, text miningPubMed
Comparative transcriptomics analysis of histone deacetylases, transcription factors, and ion channel genes in human iPSC-cardiomyocytes vs. the adult human heart.J Precis Med (Amst)202642644057PubTator, text miningPubMed

1 to 10 of 3,420

See all 3,420 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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