Gene · 3759
KCNJ2: potassium inwardly rectifying channel subfamily J member 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. KCNJ2: potassium inwardly rectifying channel subfamily J member 2. Genes, record 3759. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3759
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P63252 | Inward rectifier potassium channel 2 | 427 | 3 | Ensembl, GeneID, HGNC |
Source UniProt
Patents52
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 58668 | P63252 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 58669 | P63252 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 2228 | P63252 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 2228 | P63252 | Espacenet |
| KR 1020240158140 A | 2024-11-04 | 8 | P63252 | Espacenet |
| EP 4450514 A2 | 2024-10-23 | 79 | P63252 | Espacenet |
| US 11980671 B2 | 2024-05-14 | 27 | P63252 | Espacenet |
| JP 2024517810 A | 2024-04-23 | 81 | P63252 | Espacenet |
| JP 2023520374 A | 2023-05-17 | 40 | P63252 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 65658 | P63252 | Espacenet |
1 to 10 of 52
See all 52 patentsDrugs2
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
Trials25
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT06096337 | DRONEDARONE | ClinicalTrials.gov | ||
| NCT05939076 | DRONEDARONE | PHASE3 | ClinicalTrials.gov | |
| NCT05655468 | DRONEDARONE | PHASE4 | ClinicalTrials.gov | |
| NCT05279833 | DRONEDARONE | ClinicalTrials.gov | ||
| NCT05130268 | DRONEDARONE | PHASE4 | ClinicalTrials.gov | |
| NCT04942834 | DRONEDARONE | ClinicalTrials.gov | ||
| NCT04704050 | DRONEDARONE | PHASE4 | 2025-10-16 | ClinicalTrials.gov |
| NCT02825979 | DRONEDARONE | ClinicalTrials.gov | ||
| NCT02294955 | DRONEDARONE | ClinicalTrials.gov | ||
| NCT01991119 | DRONEDARONE | ClinicalTrials.gov |
1 to 10 of 25
See all 25 trialsNIH grants2,391
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | KCNJ2 papers | Newest fiscal year |
|---|---|---|---|
| R01HL059949 | Structural Determinants of PIP2 Regulation | 17 | 2025 |
| R01HL092577 | IDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVAL | 13 | 2025 |
| P30DK063491 | Diabetes Research Center (DRC) | 10 | 2025 |
| R01HL113006 | Human Induced Pluripotent Stem Cells for Cardiovascular Disease Modeling | 9 | 2025 |
| T32HL007936 | Training Program in Translational Cardiovascular Science | 8 | 2025 |
| R35HL140027 | Capillaries as a Sensory Web that Controls Cerebral Blood Flow in Health and Disease | 7 | 2025 |
| T32HL007572 | Research Methods in Pediatric Cardiovascular Disease | 7 | 2025 |
| R01DK054231 | Molecular of ROMK Channel Function | 6 | 2025 |
| R01HL130020 | Elucidating Mechanism of Cardiac Fibrosis with Cell Village of Pooled Human iPSCs | 6 | 2025 |
| R01HL131517 | Sex-specific arrhythmogenic mechanisms of atrial fibrillation | 6 | 2025 |
1 to 10 of 2,391Source NIH's project files
See all 2,391 nih grantsPapers3,420
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Two Pulses per Beat: Parallel Energetics of Myocardium and Coronary Wall. | Physiology (Bethesda) | 2027 | 42490304 | PubTator, text mining | PubMed |
| Brain endothelial homeostasis in psychiatric disorders: mechanisms, evidence, and translational opportunities. | Front Cell Neurosci | 2026 | 42819782 | PubTator, text mining | PubMed |
| Targeting the miR-3156-3p/K+ channel axis suppresses viral release and paralysis in enterovirus D68 infection. | Mol Ther | 2026 | 42817166 | PubTator, text mining | PubMed |
| Genetic loci responsible for atrioventricular block in children. | Front Cell Dev Biol | 2026 | 42798645 | PubTator, text mining | PubMed |
| Selective inhibition of LY294002 across cloned human cardiac ion channels: implications for atrium-selective therapy in atrial fibrillation. | Front Pharmacol | 2026 | 42780784 | PubTator, text mining | PubMed |
Perfluorooctanoic acid-associated complement factor B upregulation and atrial fibrillation-related molecular alterations: integrated network toxicology, Mendelian randomization, molecular dynamics, and HL-1 cell analyses. | Front Cardiovasc Med | 2026 | 42755451 | PubTator, text mining | PubMed |
| Diagnostic and therapeutic challenges in Andersen-Tawil syndrome. | Heart Rhythm | 2026 | 42754000 | PubTator, text mining | PubMed |
| Impaired clinical, biological, and cytokine patterns in HIV-1 exposed uninfected newborns in Yaoundé: A comparative study of neonatal immune vulnerability. | Afr J Lab Med | 2026 | 42698915 | PubTator, text mining | PubMed |
| Membrane Potential Hyperpolarization Controls the Osteogenic Differentiation of Human Dental Follicle Stem Cells by Increasing Intracellular Ca2+ Levels. | Front Biosci (Landmark Ed) | 2026 | 42689977 | PubTator, text mining | PubMed |
| Comparative transcriptomics analysis of histone deacetylases, transcription factors, and ion channel genes in human iPSC-cardiomyocytes vs. the adult human heart. | J Precis Med (Amst) | 2026 | 42644057 | PubTator, text mining | PubMed |
1 to 10 of 3,420
See all 3,420 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/3759
GET https://conductscience.org/api/genes/v1/3759/patents?page=2