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Gene · 3783

KCNN4: potassium calcium-activated channel subfamily N member 4

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. KCNN4: potassium calcium-activated channel subfamily N member 4. Genes, record 3783. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3783

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Gene

Symbol
KCNN4
HGNC
Name
potassium calcium-activated channel subfamily N member 4
HGNC
NCBI Gene ID
3783
NCBI Gene
HGNC ID
HGNC:6293
HGNC
Ensembl
ENSG00000104783
NCBI Gene
Aliases
DHS2, IK, IK1, IKCA1, KCA4, KCa3.1, SK4, SKCa4, hIK1, hIKCa1, hKCa4, hSK4
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O15554Intermediate conductance calcium-activated potassium channel protein 442717Ensembl, GeneID, HGNC

Source UniProt

Patents70

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1458630O15554Espacenet
EP 4641201 A22025-10-2925241O15554Espacenet
JP 2025158948 A2025-10-173O15554Espacenet
JP 2025147176 A2025-10-067391O15554Espacenet
JP 2025529142 A2025-09-042258O15554Espacenet
JP 2025529142 A2025-09-046800O15554Espacenet
US 12371689 B22025-07-292258O15554Espacenet
US 12371689 B22025-07-296800O15554Espacenet
JP 2025517969 A2025-06-1225241O15554Espacenet
JP 2025028160 A2025-02-287391O15554Espacenet

1 to 10 of 70

See all 70 patents

Drugs2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
CHLORZOXAZONECHEMBL1371Intermediate conductance calcium-activated potassium channel protein 4 openerOPENERChEMBL
SENICAPOCCHEMBL405821Intermediate conductance calcium-activated potassium channel protein 4 blockerBLOCKERChEMBL

Trials9

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07284069SENICAPOCEARLY_PHASE1ClinicalTrials.gov
NCT07282210SENICAPOCPHASE2ClinicalTrials.gov
NCT04804241SENICAPOCPHASE2ClinicalTrials.gov
NCT04594668SENICAPOCPHASE2ClinicalTrials.gov
NCT00861211SENICAPOCPHASE2ClinicalTrials.gov
NCT00861185SENICAPOCPHASE2ClinicalTrials.gov
NCT00294541SENICAPOCPHASE3ClinicalTrials.gov
NCT00102791SENICAPOCPHASE3ClinicalTrials.gov
NCT00040677SENICAPOCPHASE2ClinicalTrials.gov

NIH grants1,403

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleKCNN4 papersNewest fiscal year
R01HL131517Sex-specific arrhythmogenic mechanisms of atrial fibrillation102025
P30CA014195Cancer Center Support Grant (CCSG)62025
R01HL085844Functional interactions of cardiac ion channels62025
P01HL141084Multiscale Systems to Elucidate Susceptibility and Cardioprotective Mechanisms in Cardio-oncology52025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant52025
R01NS041435Mechanisms by which effector T cells modulate endogenous remyelination52025
T32HL086350Training Program in Basic and Translational Cardiovascular Science52025
UL1TR001863Yale Clinical and Translational Science Award52025
R01DC001919Expression of Ion Channels in the Auditory System42025
R01HL128831Vascular Dysfunction in Myocardial Ischemia and Metabolic Syndrome42025

1 to 10 of 1,403Source NIH's project files

See all 1,403 nih grants

Papers2,742

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Local targeted suppression of neocortical spreading depolarization amplitude by viral expression of KCa3.1 channels.Gene Ther202642811097PubTator, text miningPubMed
Small-Molecule NANT Therapeutics Targeting the Brain-Immune Axis in Alzheimer's Disease: Mechanisms, Clinical Progress, and Translational Challenges.Molecules202642796561PubTator, text miningPubMed
Potassium channels as an ionic checkpoint in tumor immunity.Front Pharmacol202642787526PubTator, text miningPubMed
The cornea-trigeminal axis: potassium channels as master regulators of ocular surface homeostasis and sensory transduction.Front Cell Dev Biol202642707580PubTator, text miningPubMed
Effect of glabridin on ion transport across primary human bronchial epithelial cells.Am J Physiol Cell Physiol202642686216PubTator, text miningPubMed
Comparative transcriptomics analysis of histone deacetylases, transcription factors, and ion channel genes in human iPSC-cardiomyocytes vs. the adult human heart.J Precis Med (Amst)202642644057PubTator, text miningPubMed
Mechanical force activates KCNN4 to regulate the NLRP3 inflammasome in periodontal ligament cells during orthodontic tooth movement.J Adv Res202642628920PubTator, text miningPubMed
Sub-millivolt voltage imaging reveals gap junction-mediated bioelectric contact inhibition.Nat Commun202642603816PubTator, text miningPubMed
Targeting FOSL1-KCa3.1 inhibits ferroptosis and cartilage destruction by suppressing mitochondrial hyperfusion.Acta Pharmacol Sin202642552470PubTator, text miningPubMed
Recurrent KCNN4 p.Ser314Pro variant in a child with Gardos channelopathy: a 6-year follow-up.Blood Cells Mol Dis202642546370PubTator, text miningPubMed

1 to 10 of 2,742

See all 2,742 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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GET https://conductscience.org/api/genes/v1/3783/patents?page=2