Gene · 3783
KCNN4: potassium calcium-activated channel subfamily N member 4
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. KCNN4: potassium calcium-activated channel subfamily N member 4. Genes, record 3783. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3783
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O15554 | Intermediate conductance calcium-activated potassium channel protein 4 | 427 | 17 | Ensembl, GeneID, HGNC |
Source UniProt
Patents70
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 58630 | O15554 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 25241 | O15554 | Espacenet |
| JP 2025158948 A | 2025-10-17 | 3 | O15554 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 7391 | O15554 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 2258 | O15554 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 6800 | O15554 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 2258 | O15554 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 6800 | O15554 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 25241 | O15554 | Espacenet |
| JP 2025028160 A | 2025-02-28 | 7391 | O15554 | Espacenet |
1 to 10 of 70
See all 70 patentsDrugs2
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
Trials9
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07284069 | SENICAPOC | EARLY_PHASE1 | ClinicalTrials.gov | |
| NCT07282210 | SENICAPOC | PHASE2 | ClinicalTrials.gov | |
| NCT04804241 | SENICAPOC | PHASE2 | ClinicalTrials.gov | |
| NCT04594668 | SENICAPOC | PHASE2 | ClinicalTrials.gov | |
| NCT00861211 | SENICAPOC | PHASE2 | ClinicalTrials.gov | |
| NCT00861185 | SENICAPOC | PHASE2 | ClinicalTrials.gov | |
| NCT00294541 | SENICAPOC | PHASE3 | ClinicalTrials.gov | |
| NCT00102791 | SENICAPOC | PHASE3 | ClinicalTrials.gov | |
| NCT00040677 | SENICAPOC | PHASE2 | ClinicalTrials.gov |
NIH grants1,403
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | KCNN4 papers | Newest fiscal year |
|---|---|---|---|
| R01HL131517 | Sex-specific arrhythmogenic mechanisms of atrial fibrillation | 10 | 2025 |
| P30CA014195 | Cancer Center Support Grant (CCSG) | 6 | 2025 |
| R01HL085844 | Functional interactions of cardiac ion channels | 6 | 2025 |
| P01HL141084 | Multiscale Systems to Elucidate Susceptibility and Cardioprotective Mechanisms in Cardio-oncology | 5 | 2025 |
| P30CA125123 | Baylor College of Medicine Cancer Center - Cancer Center Support Grant | 5 | 2025 |
| R01NS041435 | Mechanisms by which effector T cells modulate endogenous remyelination | 5 | 2025 |
| T32HL086350 | Training Program in Basic and Translational Cardiovascular Science | 5 | 2025 |
| UL1TR001863 | Yale Clinical and Translational Science Award | 5 | 2025 |
| R01DC001919 | Expression of Ion Channels in the Auditory System | 4 | 2025 |
| R01HL128831 | Vascular Dysfunction in Myocardial Ischemia and Metabolic Syndrome | 4 | 2025 |
1 to 10 of 1,403Source NIH's project files
See all 1,403 nih grantsPapers2,742
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Local targeted suppression of neocortical spreading depolarization amplitude by viral expression of KCa3.1 channels. | Gene Ther | 2026 | 42811097 | PubTator, text mining | PubMed |
| Small-Molecule NANT Therapeutics Targeting the Brain-Immune Axis in Alzheimer's Disease: Mechanisms, Clinical Progress, and Translational Challenges. | Molecules | 2026 | 42796561 | PubTator, text mining | PubMed |
| Potassium channels as an ionic checkpoint in tumor immunity. | Front Pharmacol | 2026 | 42787526 | PubTator, text mining | PubMed |
| The cornea-trigeminal axis: potassium channels as master regulators of ocular surface homeostasis and sensory transduction. | Front Cell Dev Biol | 2026 | 42707580 | PubTator, text mining | PubMed |
| Effect of glabridin on ion transport across primary human bronchial epithelial cells. | Am J Physiol Cell Physiol | 2026 | 42686216 | PubTator, text mining | PubMed |
| Comparative transcriptomics analysis of histone deacetylases, transcription factors, and ion channel genes in human iPSC-cardiomyocytes vs. the adult human heart. | J Precis Med (Amst) | 2026 | 42644057 | PubTator, text mining | PubMed |
| Mechanical force activates KCNN4 to regulate the NLRP3 inflammasome in periodontal ligament cells during orthodontic tooth movement. | J Adv Res | 2026 | 42628920 | PubTator, text mining | PubMed |
| Sub-millivolt voltage imaging reveals gap junction-mediated bioelectric contact inhibition. | Nat Commun | 2026 | 42603816 | PubTator, text mining | PubMed |
| Targeting FOSL1-KCa3.1 inhibits ferroptosis and cartilage destruction by suppressing mitochondrial hyperfusion. | Acta Pharmacol Sin | 2026 | 42552470 | PubTator, text mining | PubMed |
| Recurrent KCNN4 p.Ser314Pro variant in a child with Gardos channelopathy: a 6-year follow-up. | Blood Cells Mol Dis | 2026 | 42546370 | PubTator, text mining | PubMed |
1 to 10 of 2,742
See all 2,742 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/3783
GET https://conductscience.org/api/genes/v1/3783/patents?page=2