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Gene · 3785

KCNQ2: potassium voltage-gated channel subfamily Q member 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. KCNQ2: potassium voltage-gated channel subfamily Q member 2. Genes, record 3785. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3785

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Gene

Symbol
KCNQ2
HGNC
Name
potassium voltage-gated channel subfamily Q member 2
HGNC
NCBI Gene ID
3785
NCBI Gene
HGNC ID
HGNC:6296
HGNC
Ensembl
ENSG00000075043
NCBI Gene
Aliases
BFNC, DEE7, EBN, EBN1, ENB1, HNSPC, KCNA11, KV7.2, Kv7.2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O43526Potassium voltage-gated channel subfamily KQT member 287239Ensembl, GeneID, HGNC

Source UniProt

Patents48

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
WO 2026219910 A12026-10-2213O43526Espacenet
JP 2026094314 A2026-06-09105O43526Espacenet
JP 2026021360 A2026-02-10133O43526Espacenet
JP 2026004568 A2026-01-1458733O43526Espacenet
EP 4641201 A22025-10-297660O43526Espacenet
JP 2025529142 A2025-09-042260O43526Espacenet
US 12371689 B22025-07-292260O43526Espacenet
WO 2025133292 A12025-06-261O43526Espacenet
EP 4574152 A12025-06-251O43526Espacenet
JP 2025517969 A2025-06-127660O43526Espacenet

1 to 10 of 48

See all 48 patents

Drugs10

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AMIFAMPRIDINECHEMBL354077Voltage-gated potassium channel blockerBLOCKERChEMBL
AMIFAMPRIDINE PHOSPHATECHEMBL3301611Voltage-gated potassium channel blockerBLOCKERChEMBL
DALFAMPRIDINECHEMBL284348Voltage-gated potassium channel blockerBLOCKERChEMBL
EZOGABINECHEMBL41355KCNQ (Kv7) potassium channel openerOPENERChEMBL
FLINDOKALNERCHEMBL266510Voltage-gated potassium channel subunit Kv7.2 activatorACTIVATORChEMBL
FLINDOKALNERCHEMBL266510Voltage-gated potassium channel, KQT; KCNQ2(Kv7.2)/KCNQ3(Kv7.3) activatorACTIVATORChEMBL
GUANIDINECHEMBL821Voltage-gated potassium channel blockerBLOCKERChEMBL
GUANIDINE HYDROCHLORIDECHEMBL1200728Voltage-gated potassium channel blockerBLOCKERChEMBL
NERISPIRDINECHEMBL2107762Voltage-gated potassium channel blockerBLOCKERChEMBL
TEDISAMILCHEMBL113461Voltage-gated potassium channel blockerBLOCKERChEMBL

Trials96

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07532460DALFAMPRIDINEClinicalTrials.gov
NCT07185347DALFAMPRIDINEPHASE3ClinicalTrials.gov
NCT07171203DALFAMPRIDINEPHASE1ClinicalTrials.gov
NCT06853015DALFAMPRIDINEPHASE1/PHASE2ClinicalTrials.gov
NCT06751784DALFAMPRIDINEPHASE2ClinicalTrials.gov
NCT06596434DALFAMPRIDINEPHASE2ClinicalTrials.gov
NCT06333171DALFAMPRIDINEPHASE2ClinicalTrials.gov
NCT06294821DALFAMPRIDINEPHASE2ClinicalTrials.gov
NCT06136728DALFAMPRIDINEPHASE3ClinicalTrials.gov
NCT05919407AMIFAMPRIDINEPHASE3ClinicalTrials.gov

1 to 10 of 96

See all 96 trials

NIH grants1,261

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleKCNQ2 papersNewest fiscal year
R01HL122010Decrypting Variants of Uncertain Significance in Long-QT Syndrome82025
R01HL137094Role of KCNQ2 Channels in Control of Breathing82025
R01NS107671Therapeutic small molecule modulation of Kv channels82025
R35GM130377Ion Channel Transporter Interactions82025
U24NS120854ClinGen Expert Curation Panel for the Epilepsies82025
R01NS029709Excitability and Plasticity of Developing Epileptic Brain72025
T32HL007446Pathobiology of Occlusive Vascular Disease72025
P30CA034196Cancer Center Support (CORE) Grant62025
P50HD105351Boston Children's Hospital/HMS Intellectual and Developmental Disabilities Research Center62025
UL1TR001863Yale Clinical and Translational Science Award62025

1 to 10 of 1,261Source NIH's project files

See all 1,261 nih grants

Papers2,279

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Identification of a Ste20-like kinase-dependent signaling network orchestrating cytoskeletal and synaptic development of cortical neurons.Cell Commun Signal202642827256PubTator, text miningPubMed
Loose-patch recordings reveal differential Kv7-dependent effects on spontaneous excitatory activity in control and epileptic CA1.Front Neurol202642798466PubTator, text miningPubMed
Kv7 channels as pharmacological targets for central nervous system diseases.Pharmacol Rev202642772203PubTator, text miningPubMed
[Effectiveness and tolerability of ketogenic diet therapy in children with genetic developmental and epileptic encephalopathy onset within 2 years of age].Zhonghua Er Ke Za Zhi202642742013PubTator, text miningPubMed
Discovery of Novel Bicyclic Pyrazole Amides as Potent Neuronal KV7 Potassium Channel Openers with Strong Preclinical Antiseizure Activity.ACS Med Chem Lett202642741311PubTator, text miningPubMed
[Electroclinical recognition of SCN2A, SCN8A, KCNQ2, and KCNQ3 pathogenic variants].Medicina (B Aires)202642659555PubTator, text miningPubMed
Targeted Sequencing and Haplotype Analysis of Voltage-Gated Potassium Channel Genes Reveal a Potential Association of KCNV2 Haplotypes with Antiseizure Medication Response in Turkish Patients with Epilepsy.
Pharmaceuticals (Basel)202642653690PubTator, text miningPubMed
Genomic Sequencing in Neonatal Encephalopathy and Suspected Hypoxic-Ischaemic Encephalopathy: A Systematic Review.Genes (Basel)202642650055PubTator, text miningPubMed
Molecular Basis for Activation to Inhibition Switching in Kv7.2 Channel Modulators.Angew Chem Int Ed Engl202642631357PubTator, text miningPubMed
Development of a human iPSC and patient phenotyping resource for preclinical investigations of neurodevelopmental disorders.Stem Cell Res202642612424PubTator, text miningPubMed

1 to 10 of 2,279

See all 2,279 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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