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Gene · 3786

KCNQ3: potassium voltage-gated channel subfamily Q member 3

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. KCNQ3: potassium voltage-gated channel subfamily Q member 3. Genes, record 3786. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3786

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Gene

Symbol
KCNQ3
HGNC
Name
potassium voltage-gated channel subfamily Q member 3
HGNC
NCBI Gene ID
3786
NCBI Gene
HGNC ID
HGNC:6297
HGNC
Ensembl
ENSG00000184156
NCBI Gene
Aliases
BFNC2, EBN2, KV7.3, Kv7.3
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O43525Potassium voltage-gated channel subfamily KQT member 387216Ensembl, GeneID, HGNC

Source UniProt

Patents43

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026519198 A2026-06-129O43525Espacenet
JP 2026004568 A2026-01-1458741O43525Espacenet
EP 4641201 A22025-10-2911034O43525Espacenet
JP 2025529142 A2025-09-042261O43525Espacenet
US 12371689 B22025-07-292261O43525Espacenet
JP 2025517969 A2025-06-1211034O43525Espacenet
JP 2025032204 A2025-03-1130446O43525Espacenet
WO 2024231830 A12024-11-149O43525Espacenet
EP 4461818 A22024-11-1330446O43525Espacenet
JP 2023548973 A2023-11-21242O43525Espacenet

1 to 10 of 43

See all 43 patents

Drugs10

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AMIFAMPRIDINECHEMBL354077Voltage-gated potassium channel blockerBLOCKERChEMBL
AMIFAMPRIDINE PHOSPHATECHEMBL3301611Voltage-gated potassium channel blockerBLOCKERChEMBL
DALFAMPRIDINECHEMBL284348Voltage-gated potassium channel blockerBLOCKERChEMBL
EZOGABINECHEMBL41355KCNQ (Kv7) potassium channel openerOPENERChEMBL
FLINDOKALNERCHEMBL266510Voltage-gated potassium channel, KQT; KCNQ2(Kv7.2)/KCNQ3(Kv7.3) activatorACTIVATORChEMBL
FLINDOKALNERCHEMBL266510Voltage-gated potassium channel KCNQ3/KCNQ4 activatorACTIVATORChEMBL
GUANIDINECHEMBL821Voltage-gated potassium channel blockerBLOCKERChEMBL
GUANIDINE HYDROCHLORIDECHEMBL1200728Voltage-gated potassium channel blockerBLOCKERChEMBL
NERISPIRDINECHEMBL2107762Voltage-gated potassium channel blockerBLOCKERChEMBL
TEDISAMILCHEMBL113461Voltage-gated potassium channel blockerBLOCKERChEMBL

Trials96

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07532460DALFAMPRIDINEClinicalTrials.gov
NCT07185347DALFAMPRIDINEPHASE3ClinicalTrials.gov
NCT07171203DALFAMPRIDINEPHASE1ClinicalTrials.gov
NCT06853015DALFAMPRIDINEPHASE1/PHASE2ClinicalTrials.gov
NCT06751784DALFAMPRIDINEPHASE2ClinicalTrials.gov
NCT06596434DALFAMPRIDINEPHASE2ClinicalTrials.gov
NCT06333171DALFAMPRIDINEPHASE2ClinicalTrials.gov
NCT06294821DALFAMPRIDINEPHASE2ClinicalTrials.gov
NCT06136728DALFAMPRIDINEPHASE3ClinicalTrials.gov
NCT05919407AMIFAMPRIDINEPHASE3ClinicalTrials.gov

1 to 10 of 96

See all 96 trials

NIH grants958

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleKCNQ3 papersNewest fiscal year
R35GM130377Ion Channel Transporter Interactions72025
T32HL007446Pathobiology of Occlusive Vascular Disease72025
UL1TR001863Yale Clinical and Translational Science Award72025
R01HL122010Decrypting Variants of Uncertain Significance in Long-QT Syndrome62025
R01HL137094Role of KCNQ2 Channels in Control of Breathing62025
R01NS107671Therapeutic small molecule modulation of Kv channels62025
R01MH101221Rare Mutations and Autism Spectrum Disorders52025
R01NS029709Excitability and Plasticity of Developing Epileptic Brain52025
P30CA016672Cancer Center Support Grant42025
P30CA034196Cancer Center Support (CORE) Grant32025

1 to 10 of 958Source NIH's project files

See all 958 nih grants

Papers1,279

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Loose-patch recordings reveal differential Kv7-dependent effects on spontaneous excitatory activity in control and epileptic CA1.Front Neurol202642798466PubTator, text miningPubMed
Discovery of Novel Bicyclic Pyrazole Amides as Potent Neuronal KV7 Potassium Channel Openers with Strong Preclinical Antiseizure Activity.ACS Med Chem Lett202642741311PubTator, text miningPubMed
[Electroclinical recognition of SCN2A, SCN8A, KCNQ2, and KCNQ3 pathogenic variants].Medicina (B Aires)202642659555PubTator, text miningPubMed
Targeted Sequencing and Haplotype Analysis of Voltage-Gated Potassium Channel Genes Reveal a Potential Association of KCNV2 Haplotypes with Antiseizure Medication Response in Turkish Patients with Epilepsy.
Pharmaceuticals (Basel)202642653690PubTator, text miningPubMed
Assessment of gabapentin efficacy in patients with KCNQ2-developmental epileptic encephalopathy.Sci Rep202642286026PubTator, text miningPubMed
Functional screen for subtype specificity of voltage sensor-targeted Kv7 potentiators.Br J Pharmacol202642271185PubTator, text miningPubMed
Autism Spectrum Disorder and Atypical Epilepsy Presentation in KCNQ3 Mutations: Expansion of Phenotypic Spectrum With Neuroimaging Findings.Case Rep Pediatr202642255468PubTator, text miningPubMed
Discovery of Small-Molecule Inhibitors of the KCNQ1/Kv7.1 Potassium Channel with Virtual Screening and Functional Validation in Electrophysiological Assays and KCNQ1-Knockout Neural Stem Cells.ACS Chem Neurosci202642165438PubTator, text miningPubMed
Self-limited Neonatal Epilepsy associated with global developmental delay and high-threshold sensory profile: A novel KCNQ3 de novo variant unusually located in the voltage sensor S4 segment of the Kv7.3 channel subunit.
Seizure202642024975PubTator, text miningPubMed
A hypothesis on restoring neuronal membrane potential in dementia: early hit identification of 4-IPBA as a potential ion-channel modulator.In Silico Pharmacol202641930241PubTator, text miningPubMed

1 to 10 of 1,279

See all 1,279 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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