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Gene · 4017

LOXL2: lysyl oxidase like 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. LOXL2: lysyl oxidase like 2. Genes, record 4017. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4017

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Gene

Symbol
LOXL2
HGNC
Name
lysyl oxidase like 2
HGNC
NCBI Gene ID
4017
NCBI Gene
HGNC ID
HGNC:6666
HGNC
Ensembl
ENSG00000134013
NCBI Gene
Aliases
LOR, LOR2, WS9-14
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9Y4K0Lysyl oxidase homolog 27741Ensembl, GeneID, HGNC

Source UniProt

Patents99

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1452173Q9Y4K0Espacenet
EP 4650780 A22025-11-1910662Q9Y4K0Espacenet
EP 4641201 A22025-10-2911052Q9Y4K0Espacenet
JP 2025147176 A2025-10-067956Q9Y4K0Espacenet
JP 2025529142 A2025-09-046911Q9Y4K0Espacenet
US 12371689 B22025-07-296911Q9Y4K0Espacenet
JP 2025517969 A2025-06-1211052Q9Y4K0Espacenet
JP 2025517970 A2025-06-1210662Q9Y4K0Espacenet
JP 2025032204 A2025-03-1130929Q9Y4K0Espacenet
JP 2025028160 A2025-02-287956Q9Y4K0Espacenet

1 to 10 of 99

See all 99 patents

Drugs2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
LENUMLOSTATCHEMBL4116649Lysyl oxidase homolog 2 inhibitorINHIBITORChEMBL
SIMTUZUMABCHEMBL2109667Lysyl oxidase homolog 2 inhibitorINHIBITORChEMBL

Trials12

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT04054245LENUMLOSTATPHASE2ClinicalTrials.gov
NCT02466516SIMTUZUMABPHASE22019-06-26ClinicalTrials.gov
NCT01769196SIMTUZUMABPHASE22017-04-13ClinicalTrials.gov
NCT01759511SIMTUZUMABPHASE22017-04-04ClinicalTrials.gov
NCT01707472SIMTUZUMABPHASE22019-10-09ClinicalTrials.gov
NCT01672879SIMTUZUMABPHASE22019-03-27ClinicalTrials.gov
NCT01672853SIMTUZUMABPHASE22019-10-22ClinicalTrials.gov
NCT01479465SIMTUZUMABPHASE22019-04-17ClinicalTrials.gov
NCT01472198SIMTUZUMABPHASE2ClinicalTrials.gov
NCT01452308SIMTUZUMABPHASE2ClinicalTrials.gov

1 to 10 of 12

See all 12 trials

NIH grants1,453

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleLOXL2 papersNewest fiscal year
P30CA016672Cancer Center Support Grant142025
P30CA008748Cancer Center Support Grant82025
R01HL092961Epithelial-Mesenchymal Interactions in Fibrosis Resolution52025
UL1TR001863Yale Clinical and Translational Science Award52025
P30CA036727Buffett Cancer Center Support Grant42025
P30CA060553The Robert H. Lurie Comprehensive Cancer Center42025
P30CA068485Cancer Center Support Grant42025
P30CA091842Cancer Center Support Grant42025
P30CA168524The University of Kansas Cancer Center42025
P30DK020579Diabetes Research Center42025

1 to 10 of 1,453Source NIH's project files

See all 1,453 nih grants

Papers2,536

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Spatial evolution of a cachexia-promoting microenvironment in pancreatic cancer.Cell202642810340PubTator, text miningPubMed
Cuproplasia-associated LOXL2 cooperates with Helicobacter pylori infection to promote gastric cancer progression via the FAK/Src signaling axis.J Gastrointest Oncol202642703334PubTator, text miningPubMed
Mechanistic insights into Strontium-90 superficial radiotherapy in keloids: senescence-associated changes and ECM remodeling across cell-matrix scales.Front Pharmacol202642688921PubTator, text miningPubMed
Lysine Oxidation by LOXL2 in Single Strands Versus Triple Helices: Implications for Collagen-Related Diseases.Angew Chem Int Ed Engl202642665990PubTator, text miningPubMed
Liver reprogramming toward hepatocellular carcinoma following hepatitis C sustained virologic response: a narrative review.Transl Gastroenterol Hepatol202642592470PubTator, text miningPubMed
Dual-Metal Regulation of Cardiac Remodeling: Targeting the LOXL2-Ferroptosis Axis in Metal-Induced Cardiac Dysfunction.Cardiovasc Toxicol202642536278PubTator, text miningPubMed
Histology-derived prediction of a stromal remodeling program in pancreatic ductal adenocarcinoma with transcriptomic and spatial validation.Transl Oncol202642526385PubTator, text miningPubMed
LOXL 2 Promotes the Epithelial-Mesenchymal Transition and Malignant Progression of Cervical Cancer [Retraction].Onco Targets Ther202642459201PubTator, text miningPubMed
Distinct Molecular Signature of Earlobe Keloids: Integrated Transcriptomic Analysis of Extracellualr Matrix, Metalloproteinase, and Metabolic Pathways.Aesthetic Plast Surg202642414644PubTator, text miningPubMed
The Matrix Reloaded: The Hepatic Matrisome as a Therapeutic Opportunity to Fight Liver Fibrosis.Biomolecules202642352350PubTator, text miningPubMed

1 to 10 of 2,536

See all 2,536 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/4017

GET https://conductscience.org/api/genes/v1/4017/patents?page=2