Gene · 4017
LOXL2: lysyl oxidase like 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. LOXL2: lysyl oxidase like 2. Genes, record 4017. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4017
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q9Y4K0 | Lysyl oxidase homolog 2 | 774 | 1 | Ensembl, GeneID, HGNC |
Source UniProt
Patents99
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 52173 | Q9Y4K0 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 10662 | Q9Y4K0 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 11052 | Q9Y4K0 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 7956 | Q9Y4K0 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 6911 | Q9Y4K0 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 6911 | Q9Y4K0 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 11052 | Q9Y4K0 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 10662 | Q9Y4K0 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 30929 | Q9Y4K0 | Espacenet |
| JP 2025028160 A | 2025-02-28 | 7956 | Q9Y4K0 | Espacenet |
1 to 10 of 99
See all 99 patentsDrugs2
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
Trials12
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT04054245 | LENUMLOSTAT | PHASE2 | ClinicalTrials.gov | |
| NCT02466516 | SIMTUZUMAB | PHASE2 | 2019-06-26 | ClinicalTrials.gov |
| NCT01769196 | SIMTUZUMAB | PHASE2 | 2017-04-13 | ClinicalTrials.gov |
| NCT01759511 | SIMTUZUMAB | PHASE2 | 2017-04-04 | ClinicalTrials.gov |
| NCT01707472 | SIMTUZUMAB | PHASE2 | 2019-10-09 | ClinicalTrials.gov |
| NCT01672879 | SIMTUZUMAB | PHASE2 | 2019-03-27 | ClinicalTrials.gov |
| NCT01672853 | SIMTUZUMAB | PHASE2 | 2019-10-22 | ClinicalTrials.gov |
| NCT01479465 | SIMTUZUMAB | PHASE2 | 2019-04-17 | ClinicalTrials.gov |
| NCT01472198 | SIMTUZUMAB | PHASE2 | ClinicalTrials.gov | |
| NCT01452308 | SIMTUZUMAB | PHASE2 | ClinicalTrials.gov |
1 to 10 of 12
See all 12 trialsNIH grants1,453
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | LOXL2 papers | Newest fiscal year |
|---|---|---|---|
| P30CA016672 | Cancer Center Support Grant | 14 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 8 | 2025 |
| R01HL092961 | Epithelial-Mesenchymal Interactions in Fibrosis Resolution | 5 | 2025 |
| UL1TR001863 | Yale Clinical and Translational Science Award | 5 | 2025 |
| P30CA036727 | Buffett Cancer Center Support Grant | 4 | 2025 |
| P30CA060553 | The Robert H. Lurie Comprehensive Cancer Center | 4 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 4 | 2025 |
| P30CA091842 | Cancer Center Support Grant | 4 | 2025 |
| P30CA168524 | The University of Kansas Cancer Center | 4 | 2025 |
| P30DK020579 | Diabetes Research Center | 4 | 2025 |
1 to 10 of 1,453Source NIH's project files
See all 1,453 nih grantsPapers2,536
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Spatial evolution of a cachexia-promoting microenvironment in pancreatic cancer. | Cell | 2026 | 42810340 | PubTator, text mining | PubMed |
| Cuproplasia-associated LOXL2 cooperates with Helicobacter pylori infection to promote gastric cancer progression via the FAK/Src signaling axis. | J Gastrointest Oncol | 2026 | 42703334 | PubTator, text mining | PubMed |
| Mechanistic insights into Strontium-90 superficial radiotherapy in keloids: senescence-associated changes and ECM remodeling across cell-matrix scales. | Front Pharmacol | 2026 | 42688921 | PubTator, text mining | PubMed |
| Lysine Oxidation by LOXL2 in Single Strands Versus Triple Helices: Implications for Collagen-Related Diseases. | Angew Chem Int Ed Engl | 2026 | 42665990 | PubTator, text mining | PubMed |
| Liver reprogramming toward hepatocellular carcinoma following hepatitis C sustained virologic response: a narrative review. | Transl Gastroenterol Hepatol | 2026 | 42592470 | PubTator, text mining | PubMed |
| Dual-Metal Regulation of Cardiac Remodeling: Targeting the LOXL2-Ferroptosis Axis in Metal-Induced Cardiac Dysfunction. | Cardiovasc Toxicol | 2026 | 42536278 | PubTator, text mining | PubMed |
| Histology-derived prediction of a stromal remodeling program in pancreatic ductal adenocarcinoma with transcriptomic and spatial validation. | Transl Oncol | 2026 | 42526385 | PubTator, text mining | PubMed |
| LOXL 2 Promotes the Epithelial-Mesenchymal Transition and Malignant Progression of Cervical Cancer [Retraction]. | Onco Targets Ther | 2026 | 42459201 | PubTator, text mining | PubMed |
| Distinct Molecular Signature of Earlobe Keloids: Integrated Transcriptomic Analysis of Extracellualr Matrix, Metalloproteinase, and Metabolic Pathways. | Aesthetic Plast Surg | 2026 | 42414644 | PubTator, text mining | PubMed |
| The Matrix Reloaded: The Hepatic Matrisome as a Therapeutic Opportunity to Fight Liver Fibrosis. | Biomolecules | 2026 | 42352350 | PubTator, text mining | PubMed |
1 to 10 of 2,536
See all 2,536 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/4017
GET https://conductscience.org/api/genes/v1/4017/patents?page=2