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Gene · 427

ASAH1: N-acylsphingosine amidohydrolase 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ASAH1: N-acylsphingosine amidohydrolase 1. Genes, record 427. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/427

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Gene

Symbol
ASAH1
HGNC
Name
N-acylsphingosine amidohydrolase 1
HGNC
NCBI Gene ID
427
NCBI Gene
HGNC ID
HGNC:735
HGNC
Ensembl
ENSG00000104763
NCBI Gene
Aliases
AC, ACDase, ASAH, FLJ21558, PHP, PHP32, SMAPME
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q13510Acid ceramidase3952Ensembl, GeneID, HGNC

Source UniProt

Patents68

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026067851 A2026-04-21255Q13510Espacenet
EP 4650780 A22025-11-192012Q13510Espacenet
JP 2025169942 A2025-11-141171Q13510Espacenet
JP 2025147176 A2025-10-061183Q13510Espacenet
JP 2025147176 A2025-10-061184Q13510Espacenet
JP 2025147176 A2025-10-061185Q13510Espacenet
JP 2025529142 A2025-09-045534Q13510Espacenet
US 12371689 B22025-07-295534Q13510Espacenet
JP 2025517970 A2025-06-122012Q13510Espacenet
EP 4556066 A22025-05-211Q13510Espacenet

1 to 10 of 68

See all 68 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,215

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleASAH1 papersNewest fiscal year
P01CA097132Sphingolipids in Cancer Biology and Therapy532025
P30CA138313Medical University of South Carolina - Cancer Center Support Grant192025
P30CA008748Cancer Center Support Grant82025
P30CA044579University of Virginia Cancer Center Support Grant82025
R01DE016572Ceramide Signaling in the Regulation of Head & Neck Cancer Cell Death and Therapy72025
P50AA011999Southern California Research Center for ALPD and Cirrhosis62025
R35GM118128Neutral Sphingomyelinases and Bioactive Ceramides62025
UL1TR001863Yale Clinical and Translational Science Award62025
P30CA016059Massey Cancer Center - Cancer Center Support Grant52025
P30CA046934University of Colorado Cancer Center Support Grant52025

1 to 10 of 1,215Source NIH's project files

See all 1,215 nih grants

Papers1,873

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Metabolic targeting of ASAH1 in combination with carnosine as a therapeutic strategy for TNBC.Mol Metab202642815573PubTator, text miningPubMed
Lipid tail length dictates membrane disruption by carmofur analogs and reveals noncanonical modes of action.RSC Adv202642807973PubTator, text miningPubMed
Porphyromonas gingivalis-Derived Phosphoglycerol-isoC17:0-Dihydroceramide Reprograms Sphingolipid Metabolism in Human OECM-1 Oral Squamous Cell Carcinoma Cells.FASEB Bioadv202642781096PubTator, text miningPubMed
Sphingolipid metabolism contributes to sex dimorphism in COPD pathogenesis.JCI Insight202642771472PubTator, text miningPubMed
Dysregulation of Sphingolipid Metabolism in Non-Obstructive Azoospermia: Insights from Bioinformatics and a Busulfan-Induced Mouse Model.Reprod Sci202642722974PubTator, text miningPubMed
Fluorogenic Tissue-Based Assessment of Acid Ceramidase Activity.Bio Protoc202642656824PubTator, text miningPubMed
Therapeutic Effects of Ceranib-2 and Irinotecan Combination on Colon Cancer.Curr Issues Mol Biol202642651839PubTator, text miningPubMed
A 3D human retina model reveals a non-cell-autonomous and non-neuronal mechanism of photoreceptor loss in a lysosomal storage disorder.Sci Transl Med202642647598PubTator, text miningPubMed
ZMAT3 alleviates cell death in Fanconi anemia via adaptation of sphingolipid metabolism.Sci Adv202642536749PubTator, text miningPubMed
Keeping it acid ceramidase: How adiponectin protects in the glomerulus.J Pharmacol Exp Ther202642509125PubTator, text miningPubMed

1 to 10 of 1,873

See all 1,873 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/427

GET https://conductscience.org/api/genes/v1/427/patents?page=2