Gene · 427
ASAH1: N-acylsphingosine amidohydrolase 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. ASAH1: N-acylsphingosine amidohydrolase 1. Genes, record 427. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/427
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q13510 | Acid ceramidase | 395 | 2 | Ensembl, GeneID, HGNC |
Source UniProt
Patents68
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026067851 A | 2026-04-21 | 255 | Q13510 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 2012 | Q13510 | Espacenet |
| JP 2025169942 A | 2025-11-14 | 1171 | Q13510 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 1183 | Q13510 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 1184 | Q13510 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 1185 | Q13510 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 5534 | Q13510 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 5534 | Q13510 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 2012 | Q13510 | Espacenet |
| EP 4556066 A2 | 2025-05-21 | 1 | Q13510 | Espacenet |
1 to 10 of 68
See all 68 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,215
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | ASAH1 papers | Newest fiscal year |
|---|---|---|---|
| P01CA097132 | Sphingolipids in Cancer Biology and Therapy | 53 | 2025 |
| P30CA138313 | Medical University of South Carolina - Cancer Center Support Grant | 19 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 8 | 2025 |
| P30CA044579 | University of Virginia Cancer Center Support Grant | 8 | 2025 |
| R01DE016572 | Ceramide Signaling in the Regulation of Head & Neck Cancer Cell Death and Therapy | 7 | 2025 |
| P50AA011999 | Southern California Research Center for ALPD and Cirrhosis | 6 | 2025 |
| R35GM118128 | Neutral Sphingomyelinases and Bioactive Ceramides | 6 | 2025 |
| UL1TR001863 | Yale Clinical and Translational Science Award | 6 | 2025 |
| P30CA016059 | Massey Cancer Center - Cancer Center Support Grant | 5 | 2025 |
| P30CA046934 | University of Colorado Cancer Center Support Grant | 5 | 2025 |
1 to 10 of 1,215Source NIH's project files
See all 1,215 nih grantsPapers1,873
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Metabolic targeting of ASAH1 in combination with carnosine as a therapeutic strategy for TNBC. | Mol Metab | 2026 | 42815573 | PubTator, text mining | PubMed |
| Lipid tail length dictates membrane disruption by carmofur analogs and reveals noncanonical modes of action. | RSC Adv | 2026 | 42807973 | PubTator, text mining | PubMed |
| Porphyromonas gingivalis-Derived Phosphoglycerol-isoC17:0-Dihydroceramide Reprograms Sphingolipid Metabolism in Human OECM-1 Oral Squamous Cell Carcinoma Cells. | FASEB Bioadv | 2026 | 42781096 | PubTator, text mining | PubMed |
| Sphingolipid metabolism contributes to sex dimorphism in COPD pathogenesis. | JCI Insight | 2026 | 42771472 | PubTator, text mining | PubMed |
| Dysregulation of Sphingolipid Metabolism in Non-Obstructive Azoospermia: Insights from Bioinformatics and a Busulfan-Induced Mouse Model. | Reprod Sci | 2026 | 42722974 | PubTator, text mining | PubMed |
| Fluorogenic Tissue-Based Assessment of Acid Ceramidase Activity. | Bio Protoc | 2026 | 42656824 | PubTator, text mining | PubMed |
| Therapeutic Effects of Ceranib-2 and Irinotecan Combination on Colon Cancer. | Curr Issues Mol Biol | 2026 | 42651839 | PubTator, text mining | PubMed |
| A 3D human retina model reveals a non-cell-autonomous and non-neuronal mechanism of photoreceptor loss in a lysosomal storage disorder. | Sci Transl Med | 2026 | 42647598 | PubTator, text mining | PubMed |
| ZMAT3 alleviates cell death in Fanconi anemia via adaptation of sphingolipid metabolism. | Sci Adv | 2026 | 42536749 | PubTator, text mining | PubMed |
| Keeping it acid ceramidase: How adiponectin protects in the glomerulus. | J Pharmacol Exp Ther | 2026 | 42509125 | PubTator, text mining | PubMed |
1 to 10 of 1,873
See all 1,873 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/427
GET https://conductscience.org/api/genes/v1/427/patents?page=2