Gene · 4296
MAP3K11: mitogen-activated protein kinase kinase kinase 11
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. MAP3K11: mitogen-activated protein kinase kinase kinase 11. Genes, record 4296. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4296
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q16584 | Mitogen-activated protein kinase kinase kinase 11 | 847 | 4 | Ensembl, GeneID, HGNC |
Source UniProt
Patents44
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 53964 | Q16584 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 4637 | Q16584 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 4201 | Q16584 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 4201 | Q16584 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 4637 | Q16584 | Espacenet |
| JP 2024121274 A | 2024-09-06 | 14 | Q16584 | Espacenet |
| US 11884978 B2 | 2024-01-30 | 589 | Q16584 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 52516 | Q16584 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 155487 | Q16584 | Espacenet |
| US 11078247 B2 | 2021-08-03 | 6542 | Q16584 | Espacenet |
1 to 10 of 44
See all 44 patentsDrugs1
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action |
|---|---|---|---|
| CEP-1347 | CHEMBL290352 | Mitogen-activated protein kinase kinase kinase 11 inhibitor | INHIBITOR |
Source ChEMBL
Trials1
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted |
|---|---|---|---|
| NCT00040404 | CEP-1347 | PHASE2/PHASE3 |
Source ClinicalTrials.gov
NIH grants1,056
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | MAP3K11 papers | Newest fiscal year |
|---|---|---|---|
| R01NS034239 | Neuroprotective Immunity and HIV Dementia | 9 | 2025 |
| IK6BX004855 | BLR&D Research Career Scientist Award Application | 6 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 4 | 2025 |
| P30DK084567 | Mayo Center for Cell Signaling in Gastroenterology | 4 | 2025 |
| P30CA006927 | Comprehensive Cancer Center Program at Fox Chase | 3 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 3 | 2025 |
| P30CA016042 | Cancer Center Support Grant | 3 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 3 | 2025 |
| R35GM133725 | Unraveling heterogeneity of molecular mechanisms in cellular motility and morphodynamics by machine learning | 3 | 2025 |
| ZIAHL005105 | Integration of Actin Dynamics and Adhesion in Cell Migration | 3 | 2025 |
1 to 10 of 1,056Source NIH's project files
See all 1,056 nih grantsPapers1,505
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| miR-4632-5p Alleviates Lumbar Disc Degeneration by Targeting MAP3K11: A Novel Role in Mitigating Nucleus Pulposus Cell Degeneration. | Biochem Genet | 2026 | 42599634 | PubTator, text mining | PubMed |
| Vav2 is a master regulator of repair against bacterial pore-forming toxins. | Life Sci Alliance | 2026 | 42425763 | PubTator, text mining | PubMed |
| MLK3 promotes atherosclerosis by regulating ferroptosis in macrophages. | Inflamm Res | 2026 | 42323431 | PubTator, text mining | PubMed |
| Multicytokine-based transcriptome-wide association study for 7 inflammatory skin disorders identifies candidate causal genes in keratinocytes. | J Allergy Clin Immunol | 2026 | 42203178 | PubTator, text mining | PubMed |
| Coordinated chromosome motion emerges from mechanical coupling mediated by the physical spindle environment. | Mol Biol Cell | 2026 | 42054204 | PubTator, text mining | PubMed |
| Mendelian Randomization Reveals Potential Drug Targets for Multiple Sclerosis Targeting Ferroptosis. | CNS Neurol Disord Drug Targets | 2026 | 42002896 | PubTator, text mining | PubMed |
| Protein Kinase D2 Regulates GRASP65 Phosphorylation and Golgi Ribbon Unlinking During G2/M Transition. | Cells | 2026 | 41892354 | PubTator, text mining | PubMed |
| Reactive oxygen species (ROS) in cancer: from mechanism to therapeutic implications. | Signal Transduct Target Ther | 2026 | 41881983 | PubTator, text mining | PubMed |
| Plasma metabolomic profiling reveals lipid biomarkers for early detection of exercise-induced myocardial ischemia. | Medicine (Baltimore) | 2026 | 41861189 | PubTator, text mining | PubMed |
| Decoding organ fibrosis: mechanistic insights and emerging therapeutic strategies. | Signal Transduct Target Ther | 2026 | 41786685 | PubTator, text mining | PubMed |
1 to 10 of 1,505
See all 1,505 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
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The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/4296
GET https://conductscience.org/api/genes/v1/4296/patents?page=2