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Gene · 4296

MAP3K11: mitogen-activated protein kinase kinase kinase 11

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. MAP3K11: mitogen-activated protein kinase kinase kinase 11. Genes, record 4296. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4296

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Gene

Symbol
MAP3K11
HGNC
Name
mitogen-activated protein kinase kinase kinase 11
HGNC
NCBI Gene ID
4296
NCBI Gene
HGNC ID
HGNC:6850
HGNC
Ensembl
ENSG00000173327
NCBI Gene
Aliases
MEKK11, MLK-3, MLK3, PTK1, SPRK
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q16584Mitogen-activated protein kinase kinase kinase 118474Ensembl, GeneID, HGNC

Source UniProt

Patents44

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1453964Q16584Espacenet
EP 4650780 A22025-11-194637Q16584Espacenet
EP 4641201 A22025-10-294201Q16584Espacenet
JP 2025517969 A2025-06-124201Q16584Espacenet
JP 2025517970 A2025-06-124637Q16584Espacenet
JP 2024121274 A2024-09-0614Q16584Espacenet
US 11884978 B22024-01-30589Q16584Espacenet
US 11446398 B22022-09-2052516Q16584Espacenet
JP 2022524081 A2022-04-27155487Q16584Espacenet
US 11078247 B22021-08-036542Q16584Espacenet

1 to 10 of 44

See all 44 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
CEP-1347CHEMBL290352Mitogen-activated protein kinase kinase kinase 11 inhibitorINHIBITOR

Source ChEMBL

Trials1

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first posted
NCT00040404CEP-1347PHASE2/PHASE3

NIH grants1,056

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleMAP3K11 papersNewest fiscal year
R01NS034239Neuroprotective Immunity and HIV Dementia92025
IK6BX004855BLR&D Research Career Scientist Award Application62025
P30CA016672Cancer Center Support Grant42025
P30DK084567Mayo Center for Cell Signaling in Gastroenterology42025
P30CA006927Comprehensive Cancer Center Program at Fox Chase32025
P30CA008748Cancer Center Support Grant32025
P30CA016042Cancer Center Support Grant32025
P30CA068485Cancer Center Support Grant32025
R35GM133725Unraveling heterogeneity of molecular mechanisms in cellular motility and morphodynamics by machine learning32025
ZIAHL005105Integration of Actin Dynamics and Adhesion in Cell Migration32025

1 to 10 of 1,056Source NIH's project files

See all 1,056 nih grants

Papers1,505

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
miR-4632-5p Alleviates Lumbar Disc Degeneration by Targeting MAP3K11: A Novel Role in Mitigating Nucleus Pulposus Cell Degeneration.Biochem Genet202642599634PubTator, text miningPubMed
Vav2 is a master regulator of repair against bacterial pore-forming toxins.Life Sci Alliance202642425763PubTator, text miningPubMed
MLK3 promotes atherosclerosis by regulating ferroptosis in macrophages.Inflamm Res202642323431PubTator, text miningPubMed
Multicytokine-based transcriptome-wide association study for 7 inflammatory skin disorders identifies candidate causal genes in keratinocytes.J Allergy Clin Immunol202642203178PubTator, text miningPubMed
Coordinated chromosome motion emerges from mechanical coupling mediated by the physical spindle environment.Mol Biol Cell202642054204PubTator, text miningPubMed
Mendelian Randomization Reveals Potential Drug Targets for Multiple Sclerosis Targeting Ferroptosis.CNS Neurol Disord Drug Targets202642002896PubTator, text miningPubMed
Protein Kinase D2 Regulates GRASP65 Phosphorylation and Golgi Ribbon Unlinking During G2/M Transition.Cells202641892354PubTator, text miningPubMed
Reactive oxygen species (ROS) in cancer: from mechanism to therapeutic implications.Signal Transduct Target Ther202641881983PubTator, text miningPubMed
Plasma metabolomic profiling reveals lipid biomarkers for early detection of exercise-induced myocardial ischemia.Medicine (Baltimore)202641861189PubTator, text miningPubMed
Decoding organ fibrosis: mechanistic insights and emerging therapeutic strategies.Signal Transduct Target Ther202641786685PubTator, text miningPubMed

1 to 10 of 1,505

See all 1,505 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/4296

GET https://conductscience.org/api/genes/v1/4296/patents?page=2