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Gene · 4543

MTNR1A: melatonin receptor 1A

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. MTNR1A: melatonin receptor 1A. Genes, record 4543. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4543

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Gene

Symbol
MTNR1A
HGNC
Name
melatonin receptor 1A
HGNC
NCBI Gene ID
4543
NCBI Gene
HGNC ID
HGNC:7463
HGNC
Ensembl
ENSG00000168412
NCBI Gene
Aliases
MEL-1A-R, MT1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P48039Melatonin receptor type 1A3508Ensembl, GeneID, HGNC

Source UniProt

Patents25

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1453143P48039Espacenet
WO 2025259600 A22025-12-1813P48039Espacenet
JP 2025529142 A2025-09-042744P48039Espacenet
US 12371689 B22025-07-292744P48039Espacenet
US 11446398 B22022-09-2050191P48039Espacenet
US 11400116 B22022-08-023406P48039Espacenet
JP 2022524081 A2022-04-27153162P48039Espacenet
US 11078247 B22021-08-037082P48039Espacenet
US 10772934 B22020-09-151082P48039Espacenet
US 10533225 B22020-01-14149P48039Espacenet

1 to 10 of 25

See all 25 patents

Drugs5

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AGOMELATINECHEMBL10878Melatonin receptor agonistAGONISTChEMBL
MELATONINCHEMBL45Melatonin receptor agonistAGONISTChEMBL
PIROMELATINECHEMBL4297523Melatonin receptor agonistAGONISTChEMBL
RAMELTEONCHEMBL1218Melatonin receptor agonistAGONISTChEMBL
TASIMELTEONCHEMBL2103822Melatonin receptor agonistAGONISTChEMBL

Trials264

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

NIH grants371

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleMTNR1A papersNewest fiscal year
P30EY006360P30-Core Grant for Vision Research42025
I01BX004293CYP11A1-derived secosteroids as therapeutic agents in UVB induced skin cancer32025
R01AR073004Mechanism of action and function of novel secosteroid 20(OH)D3 in the skin32025
R01MH112205Molecular Details of Psychoactive Drug Actions32025
R35GM127086Structural Biology Of G Protein-Coupled Receptors32025
P30EY001583P30 Core Grant For Vision Research22025
R35GM119518pH regulation of cell surface receptors22025
R35GM122481Development and Testing of New Computational Methods for Ligand Discovery and Mechanism22025
T32CA009110Training in Areas Fundamental to Cancer Research22025
IK6BX004601BLR&D Research Career Scientist Award12025

1 to 10 of 371Source NIH's project files

See all 371 nih grants

Papers747

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Ferroptosis-driven stromal immune evasion and melatonin receptor suppression as novel predictive biomarkers of immunotherapy response in oral squamous cell carcinoma: a single-cell transcriptomic study.
Front Genet202642707754PubTator, text miningPubMed
Impact of Core Circadian Gene Variants on Glycemic Parameters and Insulin Resistance in Type 2 Diabetes: A Systematic Review.Cureus202642504374PubTator, text miningPubMed
Melatonin Promotes Human Hair Follicle Stem Cell Proliferation by Suppressing 5-AR: Implications for Treating Androgenetic Alopecia.J Craniofac Surg202642441367PubTator, text miningPubMed
Hierarchical Disruption of the Tryptophan-Melatonin Axis Contributes to Glioma Progression Through AKT/ERK/STAT3 Signalling.J Cell Mol Med202642286740PubTator, text miningPubMed
Epigenetic Shifts in MTNR1A, MTNR1B and Fn14 and Their Links to Preeclampsia Risk.Ann Hum Genet202642257518PubTator, text miningPubMed
Melatonin receptor signaling in human pathologies: from molecular mechanisms to therapeutic targets.Function (Oxf)202642139078PubTator, text miningPubMed
Melatonin maintains human umbilical vein endothelial cells function through potential regulation of the AKT-mTOR signaling pathway involving SIRT7 in preeclampsia.Mol Cell Endocrinol202642097527PubTator, text miningPubMed
Melatonin Receptor 1 and Melatonin Receptor 2 Expression During Human Kidney Development and Their Association with CAKUT.J Dev Biol202642029548PubTator, text miningPubMed
Melatonin ameliorates TNFα-induced oral epithelial cell inflammation via Keap1-Nrf2 axis modulation.Am J Transl Res202642007122PubTator, text miningPubMed
Ferroptosis in Parkinson's disease: a review of molecular mechanisms and emerging therapeutic strategies.Front Neurosci202641799880PubTator, text miningPubMed

1 to 10 of 747

See all 747 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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