Gene · 4544
MTNR1B: melatonin receptor 1B
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. MTNR1B: melatonin receptor 1B. Genes, record 4544. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4544
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P49286 | Melatonin receptor type 1B | 362 | 5 | Ensembl, GeneID, HGNC |
Source UniProt
Patents30
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 53144 | P49286 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 1219 | P49286 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 2745 | P49286 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 2745 | P49286 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 1219 | P49286 | Espacenet |
| WO 2024226499 A1 | 2024-10-31 | 19 | P49286 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 50192 | P49286 | Espacenet |
| US 11408034 B2 | 2022-08-09 | 513 | P49286 | Espacenet |
| US 11400116 B2 | 2022-08-02 | 3407 | P49286 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 153163 | P49286 | Espacenet |
1 to 10 of 30
See all 30 patentsDrugs5
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| AGOMELATINE | CHEMBL10878 | Melatonin receptor agonist | AGONIST | ChEMBL |
| MELATONIN | CHEMBL45 | Melatonin receptor agonist | AGONIST | ChEMBL |
| PIROMELATINE | CHEMBL4297523 | Melatonin receptor agonist | AGONIST | ChEMBL |
| RAMELTEON | CHEMBL1218 | Melatonin receptor agonist | AGONIST | ChEMBL |
| TASIMELTEON | CHEMBL2103822 | Melatonin receptor agonist | AGONIST | ChEMBL |
Trials264
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07576764 | MELATONIN | PHASE3 | ClinicalTrials.gov | |
| NCT07553143 | MELATONIN | ClinicalTrials.gov | ||
| NCT07549295 | MELATONIN | PHASE1 | ClinicalTrials.gov | |
| NCT07472075 | MELATONIN | PHASE2 | ClinicalTrials.gov | |
| NCT07418554 | MELATONIN | PHASE3 | ClinicalTrials.gov | |
| NCT07375693 | MELATONIN | PHASE2 | ClinicalTrials.gov | |
| NCT07369284 | MELATONIN | PHASE2 | ClinicalTrials.gov | |
| NCT07344467 | MELATONIN | ClinicalTrials.gov | ||
| NCT07343947 | MELATONIN | ClinicalTrials.gov | ||
| NCT07334197 | MELATONIN | ClinicalTrials.gov |
1 to 10 of 264
See all 264 trialsNIH grants1,231
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | MTNR1B papers | Newest fiscal year |
|---|---|---|---|
| ZIAHG000024 | Genetic analysis of type II diabetes | 21 | 2025 |
| P30DK063491 | Diabetes Research Center (DRC) | 20 | 2025 |
| R01DK062370 | Identifying Genes for Type 2 Diabetes: FUSION | 20 | 2025 |
| R01HL086694 | From GWAS loci to blood pressure genes, variants & mechanisms - Renewal | 14 | 2025 |
| P30DK020572 | Michigan Diabetes Research Center (MDRC) | 11 | 2025 |
| R01DK093757 | Genetic epidemiology of rare and regulatory variants for metabolic traits | 9 | 2025 |
| R01DK115679 | Nutrigenetics and Nutrigenomics for Precision Weight-Loss Diet Interventions | 7 | 2025 |
| UL1TR001881 | UCLA Clinical and Translational Science Institute | 7 | 2025 |
| P20GM109036 | Tulane COBRE for Clinical and Translational Research in Cardiometabolic Diseases | 6 | 2025 |
| R01HL034594 | RISK FACTORS FOR CVD IN WOMEN | 6 | 2025 |
1 to 10 of 1,231Source NIH's project files
See all 1,231 nih grantsPapers1,445
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Nutrigenomics in the prevention and management of type 2 diabetes and obesity: A systematic review of clinical trials. | Nutr Health | 2026 | 42754851 | PubTator, text mining | PubMed |
Ferroptosis-driven stromal immune evasion and melatonin receptor suppression as novel predictive biomarkers of immunotherapy response in oral squamous cell carcinoma: a single-cell transcriptomic study. | Front Genet | 2026 | 42707754 | PubTator, text mining | PubMed |
| A systematic review of genetic variations and DNA methylation alterations underlying circadian rhythm sleep-wake disorders. | Sleep Med Rev | 2026 | 42685456 | PubTator, text mining | PubMed |
| Interaction of melatonin receptor 1B (MTNR1B) genotype and type of breakfast (protein-enriched v carbohydrate-rich) on postprandial glucose response: a randomised crossover trial. | Eur J Clin Nutr | 2026 | 42521769 | PubTator, text mining | PubMed |
| CLOCK rs1801260 and MTNR1B rs10830963 Polymorphisms Modulate the Association between Cholesterol Levels and Circadian Rhythms in Arctic Residents. | Bull Exp Biol Med | 2026 | 42507090 | PubTator, text mining | PubMed |
| Genomic and lipidomic analysis reveals lipid mediation of genetic risk in gestational diabetes. | BMC Med | 2026 | 42482087 | PubTator, text mining | PubMed |
| Shared genetic architecture between psychiatric and insulin-related traits in the general population. | Neurosci Appl | 2026 | 42375481 | PubTator, text mining | PubMed |
| Melatonin Impairs Glucose Tolerance, First-Phase Insulin Secretion, and Insulin Feedback Inhibition; Interaction With MTNR1B Diabetes Risk Variant. | Diabetes Care | 2026 | 42346809 | PubTator, text mining | PubMed |
| Hierarchical Disruption of the Tryptophan-Melatonin Axis Contributes to Glioma Progression Through AKT/ERK/STAT3 Signalling. | J Cell Mol Med | 2026 | 42286740 | PubTator, text mining | PubMed |
| Epigenetic Shifts in MTNR1A, MTNR1B and Fn14 and Their Links to Preeclampsia Risk. | Ann Hum Genet | 2026 | 42257518 | PubTator, text mining | PubMed |
1 to 10 of 1,445
See all 1,445 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/4544
GET https://conductscience.org/api/genes/v1/4544/patents?page=2