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Gene · 4544

MTNR1B: melatonin receptor 1B

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. MTNR1B: melatonin receptor 1B. Genes, record 4544. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4544

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Gene

Symbol
MTNR1B
HGNC
Name
melatonin receptor 1B
HGNC
NCBI Gene ID
4544
NCBI Gene
HGNC ID
HGNC:7464
HGNC
Ensembl
ENSG00000134640
NCBI Gene
Aliases
FGQTL2, MEL-1B-R, MT2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P49286Melatonin receptor type 1B3625Ensembl, GeneID, HGNC

Source UniProt

Patents30

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1453144P49286Espacenet
EP 4641201 A22025-10-291219P49286Espacenet
JP 2025529142 A2025-09-042745P49286Espacenet
US 12371689 B22025-07-292745P49286Espacenet
JP 2025517969 A2025-06-121219P49286Espacenet
WO 2024226499 A12024-10-3119P49286Espacenet
US 11446398 B22022-09-2050192P49286Espacenet
US 11408034 B22022-08-09513P49286Espacenet
US 11400116 B22022-08-023407P49286Espacenet
JP 2022524081 A2022-04-27153163P49286Espacenet

1 to 10 of 30

See all 30 patents

Drugs5

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AGOMELATINECHEMBL10878Melatonin receptor agonistAGONISTChEMBL
MELATONINCHEMBL45Melatonin receptor agonistAGONISTChEMBL
PIROMELATINECHEMBL4297523Melatonin receptor agonistAGONISTChEMBL
RAMELTEONCHEMBL1218Melatonin receptor agonistAGONISTChEMBL
TASIMELTEONCHEMBL2103822Melatonin receptor agonistAGONISTChEMBL

Trials264

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

NIH grants1,231

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleMTNR1B papersNewest fiscal year
ZIAHG000024Genetic analysis of type II diabetes212025
P30DK063491Diabetes Research Center (DRC)202025
R01DK062370Identifying Genes for Type 2 Diabetes: FUSION202025
R01HL086694From GWAS loci to blood pressure genes, variants & mechanisms - Renewal142025
P30DK020572Michigan Diabetes Research Center (MDRC)112025
R01DK093757Genetic epidemiology of rare and regulatory variants for metabolic traits92025
R01DK115679Nutrigenetics and Nutrigenomics for Precision Weight-Loss Diet Interventions72025
UL1TR001881UCLA Clinical and Translational Science Institute72025
P20GM109036Tulane COBRE for Clinical and Translational Research in Cardiometabolic Diseases62025
R01HL034594RISK FACTORS FOR CVD IN WOMEN62025

1 to 10 of 1,231Source NIH's project files

See all 1,231 nih grants

Papers1,445

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Nutrigenomics in the prevention and management of type 2 diabetes and obesity: A systematic review of clinical trials.Nutr Health202642754851PubTator, text miningPubMed
Ferroptosis-driven stromal immune evasion and melatonin receptor suppression as novel predictive biomarkers of immunotherapy response in oral squamous cell carcinoma: a single-cell transcriptomic study.
Front Genet202642707754PubTator, text miningPubMed
A systematic review of genetic variations and DNA methylation alterations underlying circadian rhythm sleep-wake disorders.Sleep Med Rev202642685456PubTator, text miningPubMed
Interaction of melatonin receptor 1B (MTNR1B) genotype and type of breakfast (protein-enriched v carbohydrate-rich) on postprandial glucose response: a randomised crossover trial.Eur J Clin Nutr202642521769PubTator, text miningPubMed
CLOCK rs1801260 and MTNR1B rs10830963 Polymorphisms Modulate the Association between Cholesterol Levels and Circadian Rhythms in Arctic Residents.Bull Exp Biol Med202642507090PubTator, text miningPubMed
Genomic and lipidomic analysis reveals lipid mediation of genetic risk in gestational diabetes.BMC Med202642482087PubTator, text miningPubMed
Shared genetic architecture between psychiatric and insulin-related traits in the general population.Neurosci Appl202642375481PubTator, text miningPubMed
Melatonin Impairs Glucose Tolerance, First-Phase Insulin Secretion, and Insulin Feedback Inhibition; Interaction With MTNR1B Diabetes Risk Variant.Diabetes Care202642346809PubTator, text miningPubMed
Hierarchical Disruption of the Tryptophan-Melatonin Axis Contributes to Glioma Progression Through AKT/ERK/STAT3 Signalling.J Cell Mol Med202642286740PubTator, text miningPubMed
Epigenetic Shifts in MTNR1A, MTNR1B and Fn14 and Their Links to Preeclampsia Risk.Ann Hum Genet202642257518PubTator, text miningPubMed

1 to 10 of 1,445

See all 1,445 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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