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Gene · 4547

MTTP: microsomal triglyceride transfer protein

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. MTTP: microsomal triglyceride transfer protein. Genes, record 4547. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4547

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Gene

Symbol
MTTP
HGNC
Name
microsomal triglyceride transfer protein
HGNC
NCBI Gene ID
4547
NCBI Gene
HGNC ID
HGNC:7467
HGNC
Ensembl
ENSG00000138823
NCBI Gene
Aliases
ABL, MTP
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P55157Microsomal triglyceride transfer protein large subunit8942Ensembl, GeneID, HGNC

Source UniProt

Patents69

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026515744 A2026-05-19101P55157Espacenet
EP 4650780 A22025-11-192490P55157Espacenet
JP 2025169942 A2025-11-141163P55157Espacenet
JP 2025169942 A2025-11-141164P55157Espacenet
EP 4640849 A22025-10-29303P55157Espacenet
EP 4641201 A22025-10-292076P55157Espacenet
JP 2025147176 A2025-10-069061P55157Espacenet
JP 2025147176 A2025-10-069062P55157Espacenet
JP 2025529142 A2025-09-047094P55157Espacenet
US 12371689 B22025-07-297094P55157Espacenet

1 to 10 of 69

See all 69 patents

Drugs4

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
IMPLITAPIDECHEMBL2105804Microsomal triglyceride transfer protein inhibitorINHIBITORChEMBL
LOMITAPIDECHEMBL354541Microsomal triglyceride transfer protein inhibitorINHIBITORChEMBL
LOMITAPIDE MESYLATECHEMBL2105662Microsomal triglyceride transfer protein inhibitorINHIBITORChEMBL
SLX-4090CHEMBL4297326Microsomal triglyceride transfer protein inhibitorINHIBITORChEMBL

Trials17

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT02765841LOMITAPIDEPHASE3ClinicalTrials.gov
NCT02434744SLX-4090PHASE2ClinicalTrials.gov
NCT02399852LOMITAPIDEClinicalTrials.gov
NCT02173158LOMITAPIDEPHASE32018-10-10ClinicalTrials.gov
NCT02135705LOMITAPIDEClinicalTrials.gov
NCT01675154SLX-4090PHASE22021-08-19ClinicalTrials.gov
NCT01556906LOMITAPIDEPHASE22013-02-22ClinicalTrials.gov
NCT00943306LOMITAPIDEPHASE32018-05-11ClinicalTrials.gov
NCT00871936SLX-4090PHASE2ClinicalTrials.gov
NCT00810979SLX-4090PHASE2ClinicalTrials.gov

1 to 10 of 17

See all 17 trials

NIH grants1,426

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleMTTP papersNewest fiscal year
P30DK052574Host-environment interactions in the pathophysiology of digestive disease172025
R01DK051362Regulation of Mucosal Lymphocytes92025
R01DK119437Impaired VLDL secretion in progression of NAFLD and NASH in mice and humans92025
P01HL151328Triglycerides, Diabetes and Cardiovascular Disease82025
P30DK034854Integrated Epithelial and Muscosal Biology82025
R01DK044319Characterization of Mucosal Lymphocytes82025
T32HL007343Postdoctoral Training in Arteriosclerosis Research82025
P30DK020541NYR-Diabetes Research Center (NYR-DRC)72025
P30DK020579Diabetes Research Center72025
P30DK056341Washington University Nutrition Obesity Research Center72025

1 to 10 of 1,426Source NIH's project files

See all 1,426 nih grants

Papers2,741

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Abetalipoproteinemia With a Novel Microsomal Triglyceride Transfer Protein Gene Mutation and Unique Oxidized Lipoprotein Levels.J Med Cases202642730147PubTator, text miningPubMed
Durable lipid-lowering beyond 10 years with lomitapide in homozygous familial hypercholesterolemia: A real-world experience in Taiwan.J Clin Lipidol202642716851PubTator, text miningPubMed
Hypocholesterolemia in liver and cardiovascular disease: Friend or foe?J Intern Med202642657470PubTator, text miningPubMed
Comorbid Abetalipoproteinemia and Neurofibromatosis Type 1: Potential Clinical Implications of an Ultrarare Co-occurrence.Ann Intern Med Clin Cases202642614189PubTator, text miningPubMed
Long-term treatment of homozygous familial hypercholesterolemia with lomitapide: 11 years of safety and effectiveness findings from the Lomitapide Observational Worldwide Evaluation Registry.J Clin Lipidol202642613196PubTator, text miningPubMed
Lipoprotein(a) carries triglyceride species associated with incident cardiovascular disease.Atherosclerosis202642612337PubTator, text miningPubMed
Prognostic Value of Endoplasmic Reticulum Stress-Related Gene Signature in Thyroid Cancer.Curr Med Sci202642406224PubTator, text miningPubMed
ER stress-mediated impairment of hepatic lipid export is associated with steatosis in AKI-induced remote liver injury.Sci Rep202642373749PubTator, text miningPubMed
Multi-ancestry genome-wide association meta-analysis of hepatocellular carcinoma identifies 15 risk loci including MAP3K9, DHRS1, MTTP, and 8q24.21.HGG Adv202642357869PubTator, text miningPubMed
Multi-Omics Analysis Reveals New Insights into Yak Lung Under High-Altitude Adaptation.Animals (Basel)202642353386PubTator, text miningPubMed

1 to 10 of 2,741

See all 2,741 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/4547

GET https://conductscience.org/api/genes/v1/4547/patents?page=2