Gene · 4547
MTTP: microsomal triglyceride transfer protein
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. MTTP: microsomal triglyceride transfer protein. Genes, record 4547. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4547
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P55157 | Microsomal triglyceride transfer protein large subunit | 894 | 2 | Ensembl, GeneID, HGNC |
Source UniProt
Patents69
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026515744 A | 2026-05-19 | 101 | P55157 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 2490 | P55157 | Espacenet |
| JP 2025169942 A | 2025-11-14 | 1163 | P55157 | Espacenet |
| JP 2025169942 A | 2025-11-14 | 1164 | P55157 | Espacenet |
| EP 4640849 A2 | 2025-10-29 | 303 | P55157 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 2076 | P55157 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 9061 | P55157 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 9062 | P55157 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 7094 | P55157 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 7094 | P55157 | Espacenet |
1 to 10 of 69
See all 69 patentsDrugs4
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| IMPLITAPIDE | CHEMBL2105804 | Microsomal triglyceride transfer protein inhibitor | INHIBITOR | ChEMBL |
| LOMITAPIDE | CHEMBL354541 | Microsomal triglyceride transfer protein inhibitor | INHIBITOR | ChEMBL |
| LOMITAPIDE MESYLATE | CHEMBL2105662 | Microsomal triglyceride transfer protein inhibitor | INHIBITOR | ChEMBL |
| SLX-4090 | CHEMBL4297326 | Microsomal triglyceride transfer protein inhibitor | INHIBITOR | ChEMBL |
Trials17
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT02765841 | LOMITAPIDE | PHASE3 | ClinicalTrials.gov | |
| NCT02434744 | SLX-4090 | PHASE2 | ClinicalTrials.gov | |
| NCT02399852 | LOMITAPIDE | ClinicalTrials.gov | ||
| NCT02173158 | LOMITAPIDE | PHASE3 | 2018-10-10 | ClinicalTrials.gov |
| NCT02135705 | LOMITAPIDE | ClinicalTrials.gov | ||
| NCT01675154 | SLX-4090 | PHASE2 | 2021-08-19 | ClinicalTrials.gov |
| NCT01556906 | LOMITAPIDE | PHASE2 | 2013-02-22 | ClinicalTrials.gov |
| NCT00943306 | LOMITAPIDE | PHASE3 | 2018-05-11 | ClinicalTrials.gov |
| NCT00871936 | SLX-4090 | PHASE2 | ClinicalTrials.gov | |
| NCT00810979 | SLX-4090 | PHASE2 | ClinicalTrials.gov |
1 to 10 of 17
See all 17 trialsNIH grants1,426
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | MTTP papers | Newest fiscal year |
|---|---|---|---|
| P30DK052574 | Host-environment interactions in the pathophysiology of digestive disease | 17 | 2025 |
| R01DK051362 | Regulation of Mucosal Lymphocytes | 9 | 2025 |
| R01DK119437 | Impaired VLDL secretion in progression of NAFLD and NASH in mice and humans | 9 | 2025 |
| P01HL151328 | Triglycerides, Diabetes and Cardiovascular Disease | 8 | 2025 |
| P30DK034854 | Integrated Epithelial and Muscosal Biology | 8 | 2025 |
| R01DK044319 | Characterization of Mucosal Lymphocytes | 8 | 2025 |
| T32HL007343 | Postdoctoral Training in Arteriosclerosis Research | 8 | 2025 |
| P30DK020541 | NYR-Diabetes Research Center (NYR-DRC) | 7 | 2025 |
| P30DK020579 | Diabetes Research Center | 7 | 2025 |
| P30DK056341 | Washington University Nutrition Obesity Research Center | 7 | 2025 |
1 to 10 of 1,426Source NIH's project files
See all 1,426 nih grantsPapers2,741
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Abetalipoproteinemia With a Novel Microsomal Triglyceride Transfer Protein Gene Mutation and Unique Oxidized Lipoprotein Levels. | J Med Cases | 2026 | 42730147 | PubTator, text mining | PubMed |
| Durable lipid-lowering beyond 10 years with lomitapide in homozygous familial hypercholesterolemia: A real-world experience in Taiwan. | J Clin Lipidol | 2026 | 42716851 | PubTator, text mining | PubMed |
| Hypocholesterolemia in liver and cardiovascular disease: Friend or foe? | J Intern Med | 2026 | 42657470 | PubTator, text mining | PubMed |
| Comorbid Abetalipoproteinemia and Neurofibromatosis Type 1: Potential Clinical Implications of an Ultrarare Co-occurrence. | Ann Intern Med Clin Cases | 2026 | 42614189 | PubTator, text mining | PubMed |
| Long-term treatment of homozygous familial hypercholesterolemia with lomitapide: 11 years of safety and effectiveness findings from the Lomitapide Observational Worldwide Evaluation Registry. | J Clin Lipidol | 2026 | 42613196 | PubTator, text mining | PubMed |
| Lipoprotein(a) carries triglyceride species associated with incident cardiovascular disease. | Atherosclerosis | 2026 | 42612337 | PubTator, text mining | PubMed |
| Prognostic Value of Endoplasmic Reticulum Stress-Related Gene Signature in Thyroid Cancer. | Curr Med Sci | 2026 | 42406224 | PubTator, text mining | PubMed |
| ER stress-mediated impairment of hepatic lipid export is associated with steatosis in AKI-induced remote liver injury. | Sci Rep | 2026 | 42373749 | PubTator, text mining | PubMed |
| Multi-ancestry genome-wide association meta-analysis of hepatocellular carcinoma identifies 15 risk loci including MAP3K9, DHRS1, MTTP, and 8q24.21. | HGG Adv | 2026 | 42357869 | PubTator, text mining | PubMed |
| Multi-Omics Analysis Reveals New Insights into Yak Lung Under High-Altitude Adaptation. | Animals (Basel) | 2026 | 42353386 | PubTator, text mining | PubMed |
1 to 10 of 2,741
See all 2,741 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
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The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/4547
GET https://conductscience.org/api/genes/v1/4547/patents?page=2