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Gene · 4882

NPR2: natriuretic peptide receptor 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. NPR2: natriuretic peptide receptor 2. Genes, record 4882. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4882

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Gene

Symbol
NPR2
HGNC
Name
natriuretic peptide receptor 2
HGNC
NCBI Gene ID
4882
NCBI Gene
HGNC ID
HGNC:7944
HGNC
Ensembl
ENSG00000159899
NCBI Gene
Aliases
AMDM, ANPRB, ANPb, ECDM, GC-B, GCB, GUC2B, GUCY2B, NPRB, NPRBi, SNSK
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P20594Atrial natriuretic peptide receptor 21,0470Ensembl, GeneID, HGNC

Source UniProt

Patents37

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1455059P20594Espacenet
EP 4650780 A22025-11-196616P20594Espacenet
EP 4641201 A22025-10-296361P20594Espacenet
JP 2025529142 A2025-09-042890P20594Espacenet
US 12371689 B22025-07-292890P20594Espacenet
JP 2025517969 A2025-06-126361P20594Espacenet
JP 2025517970 A2025-06-126616P20594Espacenet
US 11446398 B22022-09-2055368P20594Espacenet
JP 2022524081 A2022-04-27158339P20594Espacenet
US 11078247 B22021-08-037632P20594Espacenet

1 to 10 of 37

See all 37 patents

Drugs2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
CARPERITIDECHEMBL2104386Atrial natriuretic peptide receptor agonistAGONISTChEMBL
VOSORITIDECHEMBL3707276Atrial natriuretic peptide receptor B binding agentBINDING AGENTChEMBL

Trials18

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07441876VOSORITIDEPHASE2/PHASE3ClinicalTrials.gov
NCT07126262VOSORITIDEPHASE2ClinicalTrials.gov
NCT07073014VOSORITIDEPHASE3ClinicalTrials.gov
NCT06668805VOSORITIDEPHASE2ClinicalTrials.gov
NCT06455059VOSORITIDEPHASE3ClinicalTrials.gov
NCT05849389VOSORITIDEPHASE2ClinicalTrials.gov
NCT05845749VOSORITIDEPHASE1/PHASE2ClinicalTrials.gov
NCT04554940VOSORITIDEPHASE2ClinicalTrials.gov
NCT04219007VOSORITIDEPHASE2ClinicalTrials.gov
NCT03989947VOSORITIDEPHASE2ClinicalTrials.gov

1 to 10 of 18

See all 18 trials

NIH grants1,069

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleNPR2 papersNewest fiscal year
P30CA008748Cancer Center Support Grant152025
P30CA016672Cancer Center Support Grant142025
ZIABC011006Molecular diagnosis and outcome prediction in lymphoma72025
ZIAHD000640Regulation Of Childhood Growth72025
P30CA060553The Robert H. Lurie Comprehensive Cancer Center62025
ZIASC000550Lymphoma Disease Discovery and Definition62025
T32DK007203Training Grant in Diabetes and Endocrinology to Enhance Metabolic Healthspan52025
ZIABC011354Targeted treatment of B-cell Lymphoma52025
ZIASC006741Therapeutic Strategies and Molecular Correlates in Aggressive B-cell Lymphomas52025
P30CA091842Cancer Center Support Grant42025

1 to 10 of 1,069Source NIH's project files

See all 1,069 nih grants

Papers1,917

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Idiopathic short stature in the genomic era: a focused narrative review of genotype-phenotype correlation, selective neuroimaging, IGF-1 biology, and growth hormone responsiveness.Clin Pediatr Endocrinol202642824949PubTator, text miningPubMed
Identification of key genes and mechanistic exploration of metabolic reprogramming in osteoporosis.J Int Med Res202642805907PubTator, text miningPubMed
Familial short stature: genetic architecture, risk stratification, and precision management.Front Endocrinol (Lausanne)202642713069PubTator, text miningPubMed
Perceived Impact of Vosoritide on Health-Related Quality of Life in Children with Selected Genetic Causes of Short Stature: A Qualitative Study of Children and Caregivers.Horm Res Paediatr202642696489PubTator, text miningPubMed
Slipped Capital Femoral Epiphysis during Vosoritide Therapy for Short Stature: A Case Series.Horm Res Paediatr202642678892PubTator, text miningPubMed
Nano-enabled natriuretic peptide therapy in post-myocardial infarction heart failure: from functional NP deficiency to dual-axis (cGMP-dependent and -independent) cardioprotection.Intern Emerg Med202642665772PubTator, text miningPubMed
Beyond biomarkers: designer natriuretic peptides and cGMP centered therapies for cardiorenal and cardiometabolic protection in chronic heart failure.Intern Emerg Med202642645729PubTator, text miningPubMed
Precision medicine in pediatric growth disorders: Integrating clinical phenotype, genetics, IGF-1 biology and artificial intelligence: A systematic scoping review of PubMed-indexed literature (2000-2026).
Growth Horm IGF Res202642628320PubTator, text miningPubMed
A synonymous NPR2 variant causes acromesomelic dysplasia through aberrant pre-mRNA splicing.Differentiation202642442044PubTator, text miningPubMed
Novel NPR2 heterozygous variant in a familial short stature and the therapeutic response to rhGH: a case report.J Pediatr Endocrinol Metab202642438924PubTator, text miningPubMed

1 to 10 of 1,917

See all 1,917 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/4882

GET https://conductscience.org/api/genes/v1/4882/patents?page=2