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Gene · 4938

OAS1: 2'-5'-oligoadenylate synthetase 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. OAS1: 2'-5'-oligoadenylate synthetase 1. Genes, record 4938. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4938

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Gene

Symbol
OAS1
HGNC
Name
2'-5'-oligoadenylate synthetase 1
HGNC
NCBI Gene ID
4938
NCBI Gene
HGNC ID
HGNC:8086
HGNC
Ensembl
ENSG00000089127
NCBI Gene
Aliases
E18/E16, IFI-4, IMD100, OIAS, OIASI
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P009732'-5'-oligoadenylate synthase 14001Ensembl, GeneID, HGNC

Source UniProt

Patents51

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
WO 2026148146 A12026-07-091P00973Espacenet
JP 2026004568 A2026-01-1435689P00973Espacenet
WO 2025252547 A12025-12-1188P00973Espacenet
EP 4660322 A12025-12-1088P00973Espacenet
EP 4640849 A22025-10-2928P00973Espacenet
EP 4641201 A22025-10-29189P00973Espacenet
JP 2025519096 A2025-06-2428P00973Espacenet
JP 2025517969 A2025-06-12189P00973Espacenet
JP 2025062604 A2025-04-14125P00973Espacenet
WO 2025016918 A12025-01-2388P00973Espacenet

1 to 10 of 51

See all 51 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,799

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleOAS1 papersNewest fiscal year
P30CA008748Cancer Center Support Grant152025
P51OD010425Washington National Primate Research Center102025
P51OD011132Emory National Primate Research Center102025
P51OD011133The Southwest National Primate Research Center102025
U19AI057266Vaccine and Infection Induced Immunity in the Young and Aged102025
UL1TR001866Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational Success92025
P30AI027763UCSF-Bay Area Center for AIDS Research72025
P30CA091842Cancer Center Support Grant72025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant72025
U19AI135972SARS-CoV adaptations through a Systems Biology Lens (SYBIL)72025

1 to 10 of 2,799Source NIH's project files

See all 2,799 nih grants

Papers3,817

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Advances in Cytosolic dsRNA Sensing of Viral Infections.Immunol Cell Biol202642802076PubTator, text miningPubMed
In vitro functional characterization of Tadarida brasiliensis interferon-β: promoter responsiveness, antiviral activity, and JAK-dependent transcriptional responses.Front Immunol202642755578PubTator, text miningPubMed
Different Effects of Acute and Chronic Hypoxia on Antiviral Capacity of Pulmonary Vascular Endothelial Cells.J Immunol Res202642689458PubTator, text miningPubMed
Class I capsid assembly modulators induce potent anti-HBV activity through direct viral suppression, innate immune activation and caspase-3-independent clearance of infected hepatocytes.Antiviral Res202642674237PubTator, text miningPubMed
Integrated Functional Characterization of a Panel of Clinical Orthoflavivirus Isolates Reveals Distinct Replication and Innate Immune Response Profiles in Human Keratinocytes.Viruses202642655646PubTator, text miningPubMed
Interstitial Lung Disease in Children: Rare Genetic Variants Beyond Surfactant Dysfunction.Pediatr Pulmonol202642598967PubTator, text miningPubMed
MDM2 binds and suppresses RNA polymerase III to restrain the innate immune response to cytosolic DNA.Cell Death Differ202642557376PubTator, text miningPubMed
Functional restoration of immune defects in STAT1 gain-of-function disease following stem cell gene editing.Blood202642550765PubTator, text miningPubMed
Temporal Dynamics of Innate Immune Activation and Viral Interference During Sequential Co-Infection with Influenza A Virus and SARS-CoV-2: Molecular Mechanisms, Clinical Evidence, and Therapeutic Implications.
Int J Mol Sci202642450260PubTator, text miningPubMed
Repeated aminoglycoside exposure activates interferon-stimulated genes in human renal proximal tubular models.Arch Toxicol202642446670PubTator, text miningPubMed

1 to 10 of 3,817

See all 3,817 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/4938

GET https://conductscience.org/api/genes/v1/4938/patents?page=2