Gene · 4938
OAS1: 2'-5'-oligoadenylate synthetase 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. OAS1: 2'-5'-oligoadenylate synthetase 1. Genes, record 4938. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4938
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P00973 | 2'-5'-oligoadenylate synthase 1 | 400 | 1 | Ensembl, GeneID, HGNC |
Source UniProt
Patents51
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| WO 2026148146 A1 | 2026-07-09 | 1 | P00973 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 35689 | P00973 | Espacenet |
| WO 2025252547 A1 | 2025-12-11 | 88 | P00973 | Espacenet |
| EP 4660322 A1 | 2025-12-10 | 88 | P00973 | Espacenet |
| EP 4640849 A2 | 2025-10-29 | 28 | P00973 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 189 | P00973 | Espacenet |
| JP 2025519096 A | 2025-06-24 | 28 | P00973 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 189 | P00973 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 125 | P00973 | Espacenet |
| WO 2025016918 A1 | 2025-01-23 | 88 | P00973 | Espacenet |
1 to 10 of 51
See all 51 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants2,799
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | OAS1 papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 15 | 2025 |
| P51OD010425 | Washington National Primate Research Center | 10 | 2025 |
| P51OD011132 | Emory National Primate Research Center | 10 | 2025 |
| P51OD011133 | The Southwest National Primate Research Center | 10 | 2025 |
| U19AI057266 | Vaccine and Infection Induced Immunity in the Young and Aged | 10 | 2025 |
| UL1TR001866 | Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational Success | 9 | 2025 |
| P30AI027763 | UCSF-Bay Area Center for AIDS Research | 7 | 2025 |
| P30CA091842 | Cancer Center Support Grant | 7 | 2025 |
| P30CA125123 | Baylor College of Medicine Cancer Center - Cancer Center Support Grant | 7 | 2025 |
| U19AI135972 | SARS-CoV adaptations through a Systems Biology Lens (SYBIL) | 7 | 2025 |
1 to 10 of 2,799Source NIH's project files
See all 2,799 nih grantsPapers3,817
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Advances in Cytosolic dsRNA Sensing of Viral Infections. | Immunol Cell Biol | 2026 | 42802076 | PubTator, text mining | PubMed |
| In vitro functional characterization of Tadarida brasiliensis interferon-β: promoter responsiveness, antiviral activity, and JAK-dependent transcriptional responses. | Front Immunol | 2026 | 42755578 | PubTator, text mining | PubMed |
| Different Effects of Acute and Chronic Hypoxia on Antiviral Capacity of Pulmonary Vascular Endothelial Cells. | J Immunol Res | 2026 | 42689458 | PubTator, text mining | PubMed |
| Class I capsid assembly modulators induce potent anti-HBV activity through direct viral suppression, innate immune activation and caspase-3-independent clearance of infected hepatocytes. | Antiviral Res | 2026 | 42674237 | PubTator, text mining | PubMed |
| Integrated Functional Characterization of a Panel of Clinical Orthoflavivirus Isolates Reveals Distinct Replication and Innate Immune Response Profiles in Human Keratinocytes. | Viruses | 2026 | 42655646 | PubTator, text mining | PubMed |
| Interstitial Lung Disease in Children: Rare Genetic Variants Beyond Surfactant Dysfunction. | Pediatr Pulmonol | 2026 | 42598967 | PubTator, text mining | PubMed |
| MDM2 binds and suppresses RNA polymerase III to restrain the innate immune response to cytosolic DNA. | Cell Death Differ | 2026 | 42557376 | PubTator, text mining | PubMed |
| Functional restoration of immune defects in STAT1 gain-of-function disease following stem cell gene editing. | Blood | 2026 | 42550765 | PubTator, text mining | PubMed |
Temporal Dynamics of Innate Immune Activation and Viral Interference During Sequential Co-Infection with Influenza A Virus and SARS-CoV-2: Molecular Mechanisms, Clinical Evidence, and Therapeutic Implications. | Int J Mol Sci | 2026 | 42450260 | PubTator, text mining | PubMed |
| Repeated aminoglycoside exposure activates interferon-stimulated genes in human renal proximal tubular models. | Arch Toxicol | 2026 | 42446670 | PubTator, text mining | PubMed |
1 to 10 of 3,817
See all 3,817 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/4938
GET https://conductscience.org/api/genes/v1/4938/patents?page=2