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Gene · 495

ATP4A: ATPase H+/K+ transporting subunit alpha

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ATP4A: ATPase H+/K+ transporting subunit alpha. Genes, record 495. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/495

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Gene

Symbol
ATP4A
HGNC
Name
ATPase H+/K+ transporting subunit alpha
HGNC
NCBI Gene ID
495
NCBI Gene
HGNC ID
HGNC:819
HGNC
Ensembl
ENSG00000105675
NCBI Gene
Aliases
ATP6A
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P20648Potassium-transporting ATPase alpha chain 11,0350Ensembl, GeneID, HGNC

Source UniProt

Patents16

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1438309P20648Espacenet
EP 4641201 A22025-10-291661P20648Espacenet
JP 2025529142 A2025-09-04514P20648Espacenet
US 12371689 B22025-07-29514P20648Espacenet
JP 2025517969 A2025-06-121661P20648Espacenet
JP 2025062604 A2025-04-147528P20648Espacenet
US 11446398 B22022-09-207528P20648Espacenet
US 11400116 B22022-08-02204P20648Espacenet
JP 2022524081 A2022-04-27110499P20648Espacenet
US 11078247 B22021-08-03928P20648Espacenet

1 to 10 of 16

See all 16 patents

Drugs17

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ABEPRAZANCHEMBL4594445Potassium-transporting ATPase inhibitorINHIBITORChEMBL
DEXLANSOPRAZOLECHEMBL1201863Potassium-transporting ATPase inhibitorINHIBITORChEMBL
ESOMEPRAZOLECHEMBL1201320Potassium-transporting ATPase inhibitorINHIBITORChEMBL
ESOMEPRAZOLE MAGNESIUMCHEMBL5314366Potassium-transporting ATPase inhibitorINHIBITORChEMBL
ESOMEPRAZOLE SODIUMCHEMBL1200470Potassium-transporting ATPase inhibitorINHIBITORChEMBL
ESOMEPRAZOLE STRONTIUMCHEMBL2146140Potassium-transporting ATPase inhibitorINHIBITORChEMBL
ILAPRAZOLECHEMBL2106370Potassium-transporting ATPase inhibitorINHIBITORChEMBL
LANSOPRAZOLECHEMBL480Potassium-transporting ATPase inhibitorINHIBITORChEMBL
OMEPRAZOLECHEMBL1503Potassium-transporting ATPase inhibitorINHIBITORChEMBL
OMEPRAZOLE MAGNESIUMCHEMBL1567328Potassium-transporting ATPase inhibitorINHIBITORChEMBL

1 to 10 of 17

See all 17 drugs

Trials557

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

NIH grants317

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleATP4A papersNewest fiscal year
P30DK058404Molecular and Cellular Basis for Digestive Diseases72025
P30DK078392Digestive Health Center (DHC): Bench to Bedside Research in Pediatric Digestive Disease72025
P01CA116087H. pylori-induced Inflammation and Gastric Cancer32025
P30CA068485Cancer Center Support Grant32025
I01BX000930Oxyntic Atrophy and Novel Gastric Lineages.22025
P30CA008748Cancer Center Support Grant22025
R01AG011085Ubiquitin‐mediated proteolysis and cell cycle control22025
R01CA077955H. Pylori Relationship to Digestive Diseases and Cancer22025
R01DK101332Induction and Evolution of Metaplasia in the Stomach22025
U2CTR002818Data Management and Coordinating Center: Rare Diseases Clinical Research Network22025

1 to 10 of 317Source NIH's project files

See all 317 nih grants

Papers461

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Efficacy of Potassium-Competitive Acid Blockers Versus Proton Pump Inhibitors in Eradication Regimens for Clarithromycin-Resistant Helicobacter pylori: A Systematic Review and Meta-Analysis.Pathogens202642796754PubTator, text miningPubMed
ClPH4-like coordinately regulates citric acid and anthocyanin accumulation in purple wampee.Hortic Res202642788159PubTator, text miningPubMed
Clinicopathological characterization of extremely low-grade fundic gland tumors: a study of 11 of a variant of oxyntic gland adenomas.Gastric Cancer202642734684PubTator, text miningPubMed
Expansion of the world health organization (WHO) gastric neuroendocrine tumor classification: introducing types 4 and 5.J Natl Cancer Inst202642730652PubTator, text miningPubMed
Letter: Proton Pump Inhibitors in Autoimmune Gastritis.Aliment Pharmacol Ther202642723153PubTator, text miningPubMed
Molecular and structural reprogramming of gastric cancer revealed by systems-level transcriptomic analysis.PLoS One202642166442PubTator, text miningPubMed
Identification of common genes associated with diabetic nephropathy and diabetic retinopathy.Front Cell Dev Biol202642131108PubTator, text miningPubMed
Co-option of Lysosomal Machinery for Sponge Biosilicification.bioRxiv202642094339PubTator, text miningPubMed
Acidosis, Iron Dyshomeostasis and Inflammatory Injury.Int J Mol Sci202641977458PubTator, text miningPubMed
A single small molecule-based human embryo model reveals V-ATPase requirement in mammalian blastocyst cavitation.Cell Res202641936702PubTator, text miningPubMed

1 to 10 of 461

See all 461 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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