Gene · 496
ATP4B: ATPase H+/K+ transporting subunit beta
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. ATP4B: ATPase H+/K+ transporting subunit beta. Genes, record 496. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/496
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P51164 | Potassium-transporting ATPase subunit beta | 291 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents21
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 38310 | P51164 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 515 | P51164 | Espacenet |
| WO 2025170033 A | 2025-08-14 | 3 | P51164 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 515 | P51164 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 7530 | P51164 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 7530 | P51164 | Espacenet |
| US 11400116 B2 | 2022-08-02 | 205 | P51164 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 110501 | P51164 | Espacenet |
| US 11078247 B2 | 2021-08-03 | 929 | P51164 | Espacenet |
| JP 2019054813 A | 2019-04-11 | 218745 | P51164 | Espacenet |
1 to 10 of 21
See all 21 patentsDrugs17
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| ABEPRAZAN | CHEMBL4594445 | Potassium-transporting ATPase inhibitor | INHIBITOR | ChEMBL |
| DEXLANSOPRAZOLE | CHEMBL1201863 | Potassium-transporting ATPase inhibitor | INHIBITOR | ChEMBL |
| ESOMEPRAZOLE | CHEMBL1201320 | Potassium-transporting ATPase inhibitor | INHIBITOR | ChEMBL |
| ESOMEPRAZOLE MAGNESIUM | CHEMBL5314366 | Potassium-transporting ATPase inhibitor | INHIBITOR | ChEMBL |
| ESOMEPRAZOLE SODIUM | CHEMBL1200470 | Potassium-transporting ATPase inhibitor | INHIBITOR | ChEMBL |
| ESOMEPRAZOLE STRONTIUM | CHEMBL2146140 | Potassium-transporting ATPase inhibitor | INHIBITOR | ChEMBL |
| ILAPRAZOLE | CHEMBL2106370 | Potassium-transporting ATPase inhibitor | INHIBITOR | ChEMBL |
| LANSOPRAZOLE | CHEMBL480 | Potassium-transporting ATPase inhibitor | INHIBITOR | ChEMBL |
| OMEPRAZOLE | CHEMBL1503 | Potassium-transporting ATPase inhibitor | INHIBITOR | ChEMBL |
| OMEPRAZOLE MAGNESIUM | CHEMBL1567328 | Potassium-transporting ATPase inhibitor | INHIBITOR | ChEMBL |
1 to 10 of 17
See all 17 drugsTrials557
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07576959 | VONOPRAZAN | PHASE3 | ClinicalTrials.gov | |
| NCT07563491 | ESOMEPRAZOLE | ClinicalTrials.gov | ||
| NCT07563491 | VONOPRAZAN | ClinicalTrials.gov | ||
| NCT07487142 | OMEPRAZOLE | PHASE3 | ClinicalTrials.gov | |
| NCT07439445 | VONOPRAZAN | ClinicalTrials.gov | ||
| NCT07437768 | VONOPRAZAN | ClinicalTrials.gov | ||
| NCT07408271 | RABEPRAZOLE | ClinicalTrials.gov | ||
| NCT07399054 | ESOMEPRAZOLE | ClinicalTrials.gov | ||
| NCT07358130 | RABEPRAZOLE | ClinicalTrials.gov | ||
| NCT07358130 | VONOPRAZAN | ClinicalTrials.gov |
1 to 10 of 557
See all 557 trialsNIH grants238
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | ATP4B papers | Newest fiscal year |
|---|---|---|---|
| P30DK058404 | Molecular and Cellular Basis for Digestive Diseases | 7 | 2025 |
| P30DK052574 | Host-environment interactions in the pathophysiology of digestive disease | 6 | 2025 |
| P30DK078392 | Digestive Health Center (DHC): Bench to Bedside Research in Pediatric Digestive Disease | 6 | 2025 |
| R01DK094989 | REGULATION OF ATROPHY-INDUCED PROGENITOR CELLS IN THE GASTRIC CORPUS | 4 | 2025 |
| R01DK101332 | Induction and Evolution of Metaplasia in the Stomach | 4 | 2025 |
| R01DK105129 | MECHANISMS OF CHIEF CELL DEDIFFERENTIATION | 4 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 3 | 2025 |
| I01BX000930 | Oxyntic Atrophy and Novel Gastric Lineages. | 2 | 2025 |
| P01CA116087 | H. pylori-induced Inflammation and Gastric Cancer | 2 | 2025 |
| P01HD093363 | CLEAR Consortium: Discovering the Developmental Mechanisms of Trachea-Esophageal Birth Defects | 2 | 2025 |
1 to 10 of 238Source NIH's project files
See all 238 nih grantsPapers248
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Targeting the YAP-BST2 Axis Overcomes Intrinsic Anti-PD-1 Resistance in Metastatic Gastric Cancer. | Adv Sci (Weinh) | 2026 | 42765331 | PubTator, text mining | PubMed |
| Integrative single-cell and spatial transcriptomic analyses identify LMX1B as a tumor suppressor orchestrating the GDF15-ATP4B axis in renal cell carcinoma. | Transl Oncol | 2026 | 42759406 | PubTator, text mining | PubMed |
| Genetic causal association between kidney stones and proton pump inhibitors. | Int Urol Nephrol | 2026 | 41849060 | PubTator, text mining | PubMed |
| Increased secreted PLA2 in epithelial cells promotes the progression of chronic non-atrophic gastritis to chronic atrophic gastritis through the TGF-β signaling. | PLoS One | 2026 | 41779702 | PubTator, text mining | PubMed |
| Deoxycholic Acid Drives ATP4A-Dependent Growth and Migration of Vocal Fold Leukoplakia Epithelial Cells via TGR5/JAK2/STAT3 Signaling. | J Voice | 2025 | 41320587 | PubTator, text mining | PubMed |
| Multiscale Construction, Evaluation, and Application of Organoids. | Adv Sci (Weinh) | 2025 | 41214890 | PubTator, text mining | PubMed |
| AI-Assisted Detection of Early Gastric Cancer via Visualization of Mucosal Acidity Compromise During Endoscopy. | Adv Sci (Weinh) | 2025 | 41114471 | PubTator, text mining | PubMed |
| Evolution of the Jawed Vertebrate (Gnathostomata) Stomach Through Gene Repertoire Loss: Findings from Agastric Species. | J Dev Biol | 2025 | 40843895 | PubTator, text mining | PubMed |
| MTX-induced gastrointestinal reactions in RA: Prevotella enrichment, gut dysbiosis, and PI3K/Akt/Ras/AMPK pathways. | Clin Rheumatol | 2025 | 40198451 | PubTator, text mining | PubMed |
| Identification of gastric cancer biomarkers through in-silico analysis of microarray based datasets. | Biochem Biophys Rep | 2024 | 39655267 | PubTator, text mining | PubMed |
1 to 10 of 248
See all 248 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/496
GET https://conductscience.org/api/genes/v1/496/patents?page=2