ConductScience.org, home

Gene · 496

ATP4B: ATPase H+/K+ transporting subunit beta

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. ATP4B: ATPase H+/K+ transporting subunit beta. Genes, record 496. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/496

On this page

Gene

Symbol
ATP4B
HGNC
Name
ATPase H+/K+ transporting subunit beta
HGNC
NCBI Gene ID
496
NCBI Gene
HGNC ID
HGNC:820
HGNC
Ensembl
ENSG00000186009
NCBI Gene
Aliases
ATP6B
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P51164Potassium-transporting ATPase subunit beta2910Ensembl, GeneID, HGNC

Source UniProt

Patents21

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1438310P51164Espacenet
JP 2025529142 A2025-09-04515P51164Espacenet
WO 2025170033 A2025-08-143P51164Espacenet
US 12371689 B22025-07-29515P51164Espacenet
JP 2025062604 A2025-04-147530P51164Espacenet
US 11446398 B22022-09-207530P51164Espacenet
US 11400116 B22022-08-02205P51164Espacenet
JP 2022524081 A2022-04-27110501P51164Espacenet
US 11078247 B22021-08-03929P51164Espacenet
JP 2019054813 A2019-04-11218745P51164Espacenet

1 to 10 of 21

See all 21 patents

Drugs17

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ABEPRAZANCHEMBL4594445Potassium-transporting ATPase inhibitorINHIBITORChEMBL
DEXLANSOPRAZOLECHEMBL1201863Potassium-transporting ATPase inhibitorINHIBITORChEMBL
ESOMEPRAZOLECHEMBL1201320Potassium-transporting ATPase inhibitorINHIBITORChEMBL
ESOMEPRAZOLE MAGNESIUMCHEMBL5314366Potassium-transporting ATPase inhibitorINHIBITORChEMBL
ESOMEPRAZOLE SODIUMCHEMBL1200470Potassium-transporting ATPase inhibitorINHIBITORChEMBL
ESOMEPRAZOLE STRONTIUMCHEMBL2146140Potassium-transporting ATPase inhibitorINHIBITORChEMBL
ILAPRAZOLECHEMBL2106370Potassium-transporting ATPase inhibitorINHIBITORChEMBL
LANSOPRAZOLECHEMBL480Potassium-transporting ATPase inhibitorINHIBITORChEMBL
OMEPRAZOLECHEMBL1503Potassium-transporting ATPase inhibitorINHIBITORChEMBL
OMEPRAZOLE MAGNESIUMCHEMBL1567328Potassium-transporting ATPase inhibitorINHIBITORChEMBL

1 to 10 of 17

See all 17 drugs

Trials557

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

NIH grants238

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleATP4B papersNewest fiscal year
P30DK058404Molecular and Cellular Basis for Digestive Diseases72025
P30DK052574Host-environment interactions in the pathophysiology of digestive disease62025
P30DK078392Digestive Health Center (DHC): Bench to Bedside Research in Pediatric Digestive Disease62025
R01DK094989REGULATION OF ATROPHY-INDUCED PROGENITOR CELLS IN THE GASTRIC CORPUS42025
R01DK101332Induction and Evolution of Metaplasia in the Stomach42025
R01DK105129MECHANISMS OF CHIEF CELL DEDIFFERENTIATION42025
P30CA068485Cancer Center Support Grant32025
I01BX000930Oxyntic Atrophy and Novel Gastric Lineages.22025
P01CA116087H. pylori-induced Inflammation and Gastric Cancer22025
P01HD093363CLEAR Consortium: Discovering the Developmental Mechanisms of Trachea-Esophageal Birth Defects22025

1 to 10 of 238Source NIH's project files

See all 238 nih grants

Papers248

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Targeting the YAP-BST2 Axis Overcomes Intrinsic Anti-PD-1 Resistance in Metastatic Gastric Cancer.Adv Sci (Weinh)202642765331PubTator, text miningPubMed
Integrative single-cell and spatial transcriptomic analyses identify LMX1B as a tumor suppressor orchestrating the GDF15-ATP4B axis in renal cell carcinoma.Transl Oncol202642759406PubTator, text miningPubMed
Genetic causal association between kidney stones and proton pump inhibitors.Int Urol Nephrol202641849060PubTator, text miningPubMed
Increased secreted PLA2 in epithelial cells promotes the progression of chronic non-atrophic gastritis to chronic atrophic gastritis through the TGF-β signaling.PLoS One202641779702PubTator, text miningPubMed
Deoxycholic Acid Drives ATP4A-Dependent Growth and Migration of Vocal Fold Leukoplakia Epithelial Cells via TGR5/JAK2/STAT3 Signaling.J Voice202541320587PubTator, text miningPubMed
Multiscale Construction, Evaluation, and Application of Organoids.Adv Sci (Weinh)202541214890PubTator, text miningPubMed
AI-Assisted Detection of Early Gastric Cancer via Visualization of Mucosal Acidity Compromise During Endoscopy.Adv Sci (Weinh)202541114471PubTator, text miningPubMed
Evolution of the Jawed Vertebrate (Gnathostomata) Stomach Through Gene Repertoire Loss: Findings from Agastric Species.J Dev Biol202540843895PubTator, text miningPubMed
MTX-induced gastrointestinal reactions in RA: Prevotella enrichment, gut dysbiosis, and PI3K/Akt/Ras/AMPK pathways.Clin Rheumatol202540198451PubTator, text miningPubMed
Identification of gastric cancer biomarkers through in-silico analysis of microarray based datasets.Biochem Biophys Rep202439655267PubTator, text miningPubMed

1 to 10 of 248

See all 248 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/496

GET https://conductscience.org/api/genes/v1/496/patents?page=2