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Gene · 4985

OPRD1: opioid receptor delta 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. OPRD1: opioid receptor delta 1. Genes, record 4985. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4985

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Gene

Symbol
OPRD1
HGNC
Name
opioid receptor delta 1
HGNC
NCBI Gene ID
4985
NCBI Gene
HGNC ID
HGNC:8153
HGNC
Ensembl
ENSG00000116329
NCBI Gene
Aliases
DOP, DOR, DOR1, OPRD
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P41143Delta-type opioid receptor37218Ensembl, GeneID, HGNC

Source UniProt

Patents32

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1456537P41143Espacenet
JP 2025529142 A2025-09-042950P41143Espacenet
US 12371689 B22025-07-292950P41143Espacenet
JP 2025032204 A2025-03-1132785P41143Espacenet
EP 4461818 A22024-11-1332785P41143Espacenet
JP 2023058610 A2023-04-2532785P41143Espacenet
US 11446398 B22022-09-2060151P41143Espacenet
US 11400116 B22022-08-02324P41143Espacenet
US 11352422 B22022-06-0754P41143Espacenet
JP 2022524081 A2022-04-27163122P41143Espacenet

1 to 10 of 32

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Drugs30

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ADL-5747CHEMBL4297345Delta opioid receptor agonistAGONISTChEMBL
ADL-5747 FREE BASECHEMBL561339Delta opioid receptor agonistAGONISTChEMBL
ADL-5859CHEMBL494480Delta opioid receptor agonistAGONISTChEMBL
AXOMADOLCHEMBL3989680Delta opioid receptor agonistAGONISTChEMBL
AZD-7268CHEMBL1946618Delta opioid receptor agonistAGONISTChEMBL
BENZHYDROCODONECHEMBL3137321Opioid receptors; mu/kappa/delta agonistAGONISTChEMBL
BENZHYDROCODONE HYDROCHLORIDECHEMBL3137310Opioid receptors; mu/kappa/delta agonistAGONISTChEMBL
CEBRANOPADOLCHEMBL2364605Opioid receptors; mu/kappa/delta agonistAGONISTChEMBL
CODEINECHEMBL485Opioid receptors; mu/kappa/delta agonistAGONISTChEMBL
CODEINE PHOSPHATECHEMBL6067642Opioid receptors; mu/kappa/delta agonistAGONISTChEMBL

1 to 10 of 30

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Trials496

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07398404NALTREXONEPHASE1/PHASE2ClinicalTrials.gov
NCT07285473NALTREXONEPHASE2ClinicalTrials.gov
NCT07224087NALTREXONEPHASE1ClinicalTrials.gov
NCT07224009NALTREXONEPHASE2ClinicalTrials.gov
NCT07221565NALTREXONEPHASE1/PHASE2ClinicalTrials.gov
NCT07036029NALBUPHINEPHASE1ClinicalTrials.gov
NCT07014644NALTREXONEPHASE2ClinicalTrials.gov
NCT07008443NALBUPHINEPHASE4ClinicalTrials.gov
NCT06845124NALTREXONEPHASE2ClinicalTrials.gov
NCT06809166NALTREXONEPHASE4ClinicalTrials.gov

1 to 10 of 496

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NIH grants971

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleOPRD1 papersNewest fiscal year
U10AA008401Collaborative Study on the Genetics of Alcoholism (COGA).92025
P30CA008748Cancer Center Support Grant62025
P50AA012870Center for the Translational Neuroscience of Alcoholism52025
ZIAAA000301Integrative genetics of behavior with high throughput technologies52025
R01DA008863Regulation Of Opioid Receptor Signaling by Endogenous Peptides42025
ZIACP010121Molecular Epidemiology Studies of Occupational and Environmental Exposures42025
P30CA016672Cancer Center Support Grant32025
R01DA012864Mechanisms and Cellular Function of Opioid Receptor Endocytosis32025
UL1TR001863Yale Clinical and Translational Science Award32025
DP1DA054373Identifying specific genetic pathway interactions for drug use and abuse through integrative omics22025

1 to 10 of 971Source NIH's project files

See all 971 nih grants

Papers1,054

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Optimizing a culture-based approach to detect intestinal carriage of carbapenem-resistant Pseudomonas aeruginosa in humans.J Glob Antimicrob Resist202642697436PubTator, text miningPubMed
Effect of dissolved versus total zinc levels on bacterial zinc-dependent meropenem co-resistance in River Tyne sediments.Environ Pollut202642668131PubTator, text miningPubMed
The Pharmacogenomics of Opioid Response in Cancer Pain: From Receptor Polymorphisms to Tumour-Mediated Interference-A Narrative-Critical Review.Int J Mol Sci202642589662PubTator, text miningPubMed
Role of genetic polymorphisms on opioid safety and efficacy in cancer pain: A systematic review and meta-analysis.Eur J Pharmacol202642492880PubTator, text miningPubMed
OPRD1 rs4654327 and Outcomes of Extended-Release Naltrexone in Alcohol Use Disorder: An Exploratory Prospective Pharmacogenetic Study.Psychopharmacology (Berl)202642373990PubTator, text miningPubMed
Characterization of antimicrobial resistance and virulence traits of clinical Pseudomonas mosselii isolates with reduced meropenem susceptibility and preserved imipenem susceptibility.Microbiol Spectr202642206854PubTator, text miningPubMed
The association between the T allele in rs204076 and treatment retention in patients receiving medication for opioid use disorder.Sci Rep202642135448PubTator, text miningPubMed
[OPRD1 gene polymorphism (rs4654327) as a potential predictor of the effectiveness of long-acting naltrexone in patients with alcohol addiction].Zh Nevrol Psikhiatr Im S S Korsakova202642133415PubTator, text miningPubMed
Surveillance of carbapenem-resistant Pseudomonas aeruginosa isolates obtained from patients treated in a paediatric hospital in Mexico.Sci Rep202642014478PubTator, text miningPubMed
Differences in Experimental Pain Sensitivity Between Non-African and African American Healthy Individuals and Patients with Painful Chronic Pancreatitis.J Pain Res202641788416PubTator, text miningPubMed

1 to 10 of 1,054

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Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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