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Gene · 4986

OPRK1: opioid receptor kappa 1

11 sourcesgene-search-2026-11-11-0.1.0

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ConductScience Library. OPRK1: opioid receptor kappa 1. Genes, record 4986. Release gene-search-2026-11-11-0.1.0, 11 Nov 2026. https://conductscience.org/library/genes/4986

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Gene

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

Symbol
OPRK1
HGNC
Name
opioid receptor kappa 1
HGNC
NCBI Gene ID
4986
NCBI Gene
HGNC ID
HGNC:8154
HGNC
Ensembl
ENSG00000082556
NCBI Gene
Aliases
K-OR-1, KOP, KOR, KOR-1, KOR1, OPRK
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P41145Kappa-type opioid receptor38041Ensembl, GeneID, HGNC

Source UniProt

Patents51

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1456539P41145Espacenet
JP 2026004568 A2026-01-1456541P41145Espacenet
EP 4641201 A22025-10-292082P41145Espacenet
EP 4641201 A22025-10-2939034P41145Espacenet
JP 2025154589 A2025-10-105P41145Espacenet
JP 2025529142 A2025-09-042951P41145Espacenet
US 12371689 B22025-07-292951P41145Espacenet
JP 2025517969 A2025-06-122082P41145Espacenet
JP 2025517969 A2025-06-1239034P41145Espacenet
JP 2023548973 A2023-11-21247P41145Espacenet

1 to 10 of 51

See all 51 patents

Drugs44

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ANILERIDINECHEMBL1201347Kappa opioid receptor agonistAGONISTChEMBL
ANILERIDINE HYDROCHLORIDECHEMBL1201047Kappa opioid receptor agonistAGONISTChEMBL
ANILERIDINE PHOSPHATECHEMBL1200543Kappa opioid receptor agonistAGONISTChEMBL
ASIMADOLINECHEMBL1190199Kappa opioid receptor agonistAGONISTChEMBL
ATICAPRANTCHEMBL1921847Kappa opioid receptor antagonistANTAGONISTChEMBL
AXOMADOLCHEMBL3989680Kappa opioid receptor agonistAGONISTChEMBL
BENZHYDROCODONECHEMBL3137321Opioid receptors; mu/kappa/delta agonistAGONISTChEMBL
BENZHYDROCODONE HYDROCHLORIDECHEMBL3137310Opioid receptors; mu/kappa/delta agonistAGONISTChEMBL
BUPRENORPHINECHEMBL511142Kappa opioid receptor agonistAGONISTChEMBL
BUPRENORPHINE HYDROCHLORIDECHEMBL2368861Kappa opioid receptor agonistAGONISTChEMBL

1 to 10 of 44

See all 44 drugs

Trials822

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07524738BUPRENORPHINEPHASE3ClinicalTrials.gov
NCT07430345BUPRENORPHINEPHASE1/PHASE2ClinicalTrials.gov
NCT07398404NALTREXONEPHASE1/PHASE2ClinicalTrials.gov
NCT07285473NALTREXONEPHASE2ClinicalTrials.gov
NCT07224087NALTREXONEPHASE1ClinicalTrials.gov
NCT07224009NALTREXONEPHASE2ClinicalTrials.gov
NCT07221565NALTREXONEPHASE1/PHASE2ClinicalTrials.gov
NCT07169409BUPRENORPHINEPHASE1ClinicalTrials.gov
NCT07098351NALFURAFINE HYDROCHLORIDEClinicalTrials.gov
NCT07036029NALBUPHINEPHASE1ClinicalTrials.gov

1 to 10 of 822

See all 822 trials

NIH grants2,952

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal year
R01MH063266Roles of nuleus accumbens CREB and Kappa function in depression272025
U10AA008401Collaborative Study on the Genetics of Alcoholism (COGA).182025
R01DA031927Novel Probes of the Kappa Opioid Receptor: Chemistry, Pharmacology, and Biology152025
P30CA008748Cancer Center Support Grant132025
T32DA007237Neurobiology of Addiction Training Program132025
UL1TR001863Yale Clinical and Translational Science Award132025
T32AA007565Multidisciplinary Training in the Biology of Alcohol Addiction112025
U01AA014091Alcohol/Stress Effects on Kappa Opioid Receptors in the Amygdala and Accumbens112025
ZIADA000527Medicinal Chemistry of Drugs Acting on Central and Peripheral Opioid Receptors112025
T32DA007027Training in the pharmacology of abused drugs102025

1 to 10 of 2,952Source NIH's project files

See all 2,952 nih grants

Papers4,507

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42816838PubTator, text miningPubMed
42788050PubTator, text miningPubMed
42726869PubTator, text miningPubMed
42720725PubTator, text miningPubMed
42698741PubTator, text miningPubMed
42673964PubTator, text miningPubMed
42638533PubTator, text miningPubMed
42589662PubTator, text miningPubMed
42582797PubTator, text miningPubMed
42576770PubTator, text miningPubMed

1 to 10 of 4,507

See all 4,507 papers

Sources 11

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNone stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GeneNone named. Public domain as US government information
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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