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Gene · 5024

P2RX3: purinergic receptor P2X 3

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. P2RX3: purinergic receptor P2X 3. Genes, record 5024. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5024

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Gene

Symbol
P2RX3
HGNC
Name
purinergic receptor P2X 3
HGNC
NCBI Gene ID
5024
NCBI Gene
HGNC ID
HGNC:8534
HGNC
Ensembl
ENSG00000109991
NCBI Gene
Aliases
P2X3
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P56373P2X purinoceptor 339719Ensembl, GeneID, HGNC

Source UniProt

Patents14

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1460468P56373Espacenet
JP 2025529142 A2025-09-043314P56373Espacenet
US 12371689 B22025-07-293314P56373Espacenet
US 11446398 B22022-09-2070003P56373Espacenet
US 11400116 B22022-08-027323P56373Espacenet
JP 2022524081 A2022-04-27172974P56373Espacenet
US 11078247 B22021-08-038046P56373Espacenet
JP 2019054813 A2019-04-11240903P56373Espacenet
US 10168327 B22019-01-0153P56373Espacenet
JP 2017121241 A2017-07-13240903P56373Espacenet

1 to 10 of 14

See all 14 patents

Drugs3

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
CAMLIPIXANTCHEMBL5095035P2X purinoceptor 3 antagonistANTAGONISTChEMBL
GEFAPIXANTCHEMBL3716057P2X purinoceptor 3 antagonistANTAGONISTChEMBL
GEFAPIXANT CITRATECHEMBL4594278P2X purinoceptor 3 antagonistANTAGONISTChEMBL

Trials17

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT05813223GEFAPIXANTEARLY_PHASE1ClinicalTrials.gov
NCT04693195CAMLIPIXANTPHASE2ClinicalTrials.gov
NCT04525885GEFAPIXANTPHASE32023-10-02ClinicalTrials.gov
NCT04193202GEFAPIXANTPHASE32022-10-14ClinicalTrials.gov
NCT04193176GEFAPIXANTPHASE32023-09-22ClinicalTrials.gov
NCT03882801GEFAPIXANTPHASE12020-11-19ClinicalTrials.gov
NCT03696108GEFAPIXANTPHASE32021-11-01ClinicalTrials.gov
NCT03654326GEFAPIXANTPHASE22021-07-07ClinicalTrials.gov
NCT03569033GEFAPIXANTPHASE22019-12-10ClinicalTrials.gov
NCT03482713GEFAPIXANTPHASE22019-07-05ClinicalTrials.gov

1 to 10 of 17

See all 17 trials

NIH grants184

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleP2RX3 papersNewest fiscal year
ZIAHD000195Intracellular Signaling In Endocrine Cells32025
ZIANS003018Gating mechanisms and pharmacology of P2X receptor channels32025
K12GM081259IRACDA at the University of Pennsylvania: Penn Postdoctoral Opportunities in Research and Teaching (PennPORT).12025
P30AI027763UCSF-Bay Area Center for AIDS Research12025
P30CA008748Cancer Center Support Grant12025
P30CA016087Cancer Center Support Grant12025
P30CA068485Cancer Center Support Grant12025
P30DK056338Texas Medical Center Digestive Diseases Center12025
P30ES019776HERCULES: Exposome Research Center12025
P30EY008126Core Grant in Vision Research12025

1 to 10 of 184Source NIH's project files

See all 184 nih grants

Papers438

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Reviewing the Peripheral and Central Mechanisms of Visceral Hypersensitivity in Intestinal Disorders.Int J Med Sci202641799760PubTator, text miningPubMed
Modulation of Nociceptive Ion Channels by Protease-Activated Receptor-2 in Inflammatory Pain: Molecular Mechanisms and Therapeutic Potential.Int J Mol Sci202641751907PubTator, text miningPubMed
Bladder Trigone as a Sensory Hub: A Narrative Review.Cureus202541267700PubTator, text miningPubMed
Exploring the potential pathogenesis of migraine using glutamatergic neuron models derived from induced pluripotent stem cells (iPSCs) of migraine patients.Brain Res202540930453PubTator, text miningPubMed
The Expression of F2RL1, P2RX2, P2RX3 and P2RY2 in the Esophagus of Patients with Gastroesophageal Reflux Disease and Their Relationship to Reflux Symptoms-A Pilot Study.J Clin Med202540142692PubTator, text miningPubMed
Potent painkiller from spider venom antagonizes P2X3 receptors without dysgeusia.Mol Ther202539960544PubTator, text miningPubMed
Targeting nerve growth factor for pain relief: pros and cons.Korean J Pain202439322310PubTator, text miningPubMed
Finely ordered intracellular domain harbors an allosteric site to modulate physiopathological function of P2X3 receptors.Nat Commun202439227563PubTator, text miningPubMed
The potential value of the Purinergic pathway in the prognostic assessment and clinical application of kidney renal clear cell carcinoma.Aging (Albany NY)202438180750PubTator, text miningPubMed
Gene expression changes in conjunctival cells associated with contact lens wear and discomfort.Ocul Surf202438128761PubTator, text miningPubMed

1 to 10 of 438

See all 438 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5024

GET https://conductscience.org/api/genes/v1/5024/patents