Gene · 5024
P2RX3: purinergic receptor P2X 3
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. P2RX3: purinergic receptor P2X 3. Genes, record 5024. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5024
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P56373 | P2X purinoceptor 3 | 397 | 19 | Ensembl, GeneID, HGNC |
Source UniProt
Patents14
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 60468 | P56373 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 3314 | P56373 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 3314 | P56373 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 70003 | P56373 | Espacenet |
| US 11400116 B2 | 2022-08-02 | 7323 | P56373 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 172974 | P56373 | Espacenet |
| US 11078247 B2 | 2021-08-03 | 8046 | P56373 | Espacenet |
| JP 2019054813 A | 2019-04-11 | 240903 | P56373 | Espacenet |
| US 10168327 B2 | 2019-01-01 | 53 | P56373 | Espacenet |
| JP 2017121241 A | 2017-07-13 | 240903 | P56373 | Espacenet |
1 to 10 of 14
See all 14 patentsDrugs3
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
Trials17
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT05813223 | GEFAPIXANT | EARLY_PHASE1 | ClinicalTrials.gov | |
| NCT04693195 | CAMLIPIXANT | PHASE2 | ClinicalTrials.gov | |
| NCT04525885 | GEFAPIXANT | PHASE3 | 2023-10-02 | ClinicalTrials.gov |
| NCT04193202 | GEFAPIXANT | PHASE3 | 2022-10-14 | ClinicalTrials.gov |
| NCT04193176 | GEFAPIXANT | PHASE3 | 2023-09-22 | ClinicalTrials.gov |
| NCT03882801 | GEFAPIXANT | PHASE1 | 2020-11-19 | ClinicalTrials.gov |
| NCT03696108 | GEFAPIXANT | PHASE3 | 2021-11-01 | ClinicalTrials.gov |
| NCT03654326 | GEFAPIXANT | PHASE2 | 2021-07-07 | ClinicalTrials.gov |
| NCT03569033 | GEFAPIXANT | PHASE2 | 2019-12-10 | ClinicalTrials.gov |
| NCT03482713 | GEFAPIXANT | PHASE2 | 2019-07-05 | ClinicalTrials.gov |
1 to 10 of 17
See all 17 trialsNIH grants184
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | P2RX3 papers | Newest fiscal year |
|---|---|---|---|
| ZIAHD000195 | Intracellular Signaling In Endocrine Cells | 3 | 2025 |
| ZIANS003018 | Gating mechanisms and pharmacology of P2X receptor channels | 3 | 2025 |
| K12GM081259 | IRACDA at the University of Pennsylvania: Penn Postdoctoral Opportunities in Research and Teaching (PennPORT). | 1 | 2025 |
| P30AI027763 | UCSF-Bay Area Center for AIDS Research | 1 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 1 | 2025 |
| P30CA016087 | Cancer Center Support Grant | 1 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 1 | 2025 |
| P30DK056338 | Texas Medical Center Digestive Diseases Center | 1 | 2025 |
| P30ES019776 | HERCULES: Exposome Research Center | 1 | 2025 |
| P30EY008126 | Core Grant in Vision Research | 1 | 2025 |
1 to 10 of 184Source NIH's project files
See all 184 nih grantsPapers438
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Reviewing the Peripheral and Central Mechanisms of Visceral Hypersensitivity in Intestinal Disorders. | Int J Med Sci | 2026 | 41799760 | PubTator, text mining | PubMed |
| Modulation of Nociceptive Ion Channels by Protease-Activated Receptor-2 in Inflammatory Pain: Molecular Mechanisms and Therapeutic Potential. | Int J Mol Sci | 2026 | 41751907 | PubTator, text mining | PubMed |
| Bladder Trigone as a Sensory Hub: A Narrative Review. | Cureus | 2025 | 41267700 | PubTator, text mining | PubMed |
| Exploring the potential pathogenesis of migraine using glutamatergic neuron models derived from induced pluripotent stem cells (iPSCs) of migraine patients. | Brain Res | 2025 | 40930453 | PubTator, text mining | PubMed |
| The Expression of F2RL1, P2RX2, P2RX3 and P2RY2 in the Esophagus of Patients with Gastroesophageal Reflux Disease and Their Relationship to Reflux Symptoms-A Pilot Study. | J Clin Med | 2025 | 40142692 | PubTator, text mining | PubMed |
| Potent painkiller from spider venom antagonizes P2X3 receptors without dysgeusia. | Mol Ther | 2025 | 39960544 | PubTator, text mining | PubMed |
| Targeting nerve growth factor for pain relief: pros and cons. | Korean J Pain | 2024 | 39322310 | PubTator, text mining | PubMed |
| Finely ordered intracellular domain harbors an allosteric site to modulate physiopathological function of P2X3 receptors. | Nat Commun | 2024 | 39227563 | PubTator, text mining | PubMed |
| The potential value of the Purinergic pathway in the prognostic assessment and clinical application of kidney renal clear cell carcinoma. | Aging (Albany NY) | 2024 | 38180750 | PubTator, text mining | PubMed |
| Gene expression changes in conjunctival cells associated with contact lens wear and discomfort. | Ocul Surf | 2024 | 38128761 | PubTator, text mining | PubMed |
1 to 10 of 438
See all 438 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/5024
GET https://conductscience.org/api/genes/v1/5024/patents