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Gene · 5028

P2RY1: purinergic receptor P2Y1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. P2RY1: purinergic receptor P2Y1. Genes, record 5028. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5028

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Gene

Symbol
P2RY1
HGNC
Name
purinergic receptor P2Y1
HGNC
NCBI Gene ID
5028
NCBI Gene
HGNC ID
HGNC:8539
HGNC
Ensembl
ENSG00000169860
NCBI Gene
Aliases
P2Y1, SARCC
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P47900P2Y purinoceptor 13735Ensembl, GeneID, HGNC

Source UniProt

Patents40

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1460482P47900Espacenet
JP 2025529142 A2025-09-043319P47900Espacenet
US 12371689 B22025-07-293319P47900Espacenet
JP 2025032204 A2025-03-1132814P47900Espacenet
EP 4461818 A22024-11-1332814P47900Espacenet
JP 2023058610 A2023-04-2532814P47900Espacenet
US 11446398 B22022-09-2070040P47900Espacenet
US 11400116 B22022-08-022682P47900Espacenet
JP 2022524081 A2022-04-27173011P47900Espacenet
US 11078247 B22021-08-038055P47900Espacenet

1 to 10 of 40

See all 40 patents

Drugs2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
DIQUAFOSOLCHEMBL221326Purinergic receptor P2Y1 agonistAGONISTChEMBL
DIQUAFOSOL TETRASODIUMCHEMBL1767408Purinergic receptor P2Y1 agonistAGONISTChEMBL

Trials23

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07122635DIQUAFOSOL TETRASODIUMClinicalTrials.gov
NCT07097922DIQUAFOSOL TETRASODIUMClinicalTrials.gov
NCT06903884DIQUAFOSOLPHASE3ClinicalTrials.gov
NCT06852105DIQUAFOSOL TETRASODIUMClinicalTrials.gov
NCT06537349DIQUAFOSOL TETRASODIUMClinicalTrials.gov
NCT05694026DIQUAFOSOL TETRASODIUMClinicalTrials.gov
NCT05193331DIQUAFOSOL TETRASODIUMClinicalTrials.gov
NCT04980144DIQUAFOSOL TETRASODIUMClinicalTrials.gov
NCT04548427DIQUAFOSOL TETRASODIUMPHASE3ClinicalTrials.gov
NCT03640351DIQUAFOSOLClinicalTrials.gov

1 to 10 of 23

See all 23 trials

NIH grants1,328

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleP2RY1 papersNewest fiscal year
ZIADK031116Development of P2Y Receptor Ligands452025
ZIADK031126Computer Modeling of G Protein-Coupled Receptors172025
ZIADK031117Development of Drugs Acting at Adenosine Receptors162025
P30EY001583P30 Core Grant For Vision Research72025
ZIADK031115Functionalized Congeners of Bioactive Compounds62025
P01AI045897A Tolerance Approach to Xenotransplantation52025
R01HL101972Characterization of Coagulation Factor-platelet Interactions: Role of FXI52025
R35GM127121Cell signaling by G protein-coupled receptors52025
ZIAAG000295Immobilized Proteins In Drug Discovery52025
K12GM068524San Diego IRACDA Scholars Program42025

1 to 10 of 1,328Source NIH's project files

See all 1,328 nih grants

Papers2,801

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
A Boolean Seven-Layer Platelet Decision Model Models Consistently the Logic and Semiquantitatively the Dynamics of Platelet Activation and Inhibition.Comput Struct Biotechnol J202642819776PubTator, text miningPubMed
Structure-based analysis reveals a hydrophobic pocket governing P2Y12 receptor agonist potency and selectivity.J Enzyme Inhib Med Chem202642786908PubTator, text miningPubMed
Residue Interaction Network Reveals Allosteric Pathways Linking Orthosteric and Intracellular Sites in Class A GPCRs.J Chem Inf Model202642734521PubTator, text miningPubMed
COPI Coatomer Regulates Several Steps of HDL Metabolism.Arterioscler Thromb Vasc Biol202642592650PubTator, text miningPubMed
Advances in nucleotide-based P2Y₁ antagonism: implications for cardiovascular therapeutics.Med Chem Res202642566009PubTator, text miningPubMed
Bleeding and Thromboembolic Events With Antiplatelet Agents in Pediatric Heart Disease-An Exploratory Study of the Role of Pharmacogenomics.Pediatr Blood Cancer202642499276PubTator, text miningPubMed
Adenosine triphosphate regulates metastatic behaviors of oral squamous cell carcinoma cells.Sci Rep202642477432PubTator, text miningPubMed
Liver Fibrosis and Purinergic Signaling: Autocrine-Paracrine Role of ATP in Liver Damage.Int J Mol Sci202642450299PubTator, text miningPubMed
Harnessing flavonoids as innovative agents for the modulation of platelet activation and thrombotic disorders.Mol Biol Rep202642397528PubTator, text miningPubMed
Inhibition of (interstitial) P2Y6 receptors attenuates fibrosis progression.Pflugers Arch202642303751PubTator, text miningPubMed

1 to 10 of 2,801

See all 2,801 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5028

GET https://conductscience.org/api/genes/v1/5028/patents?page=2