ConductScience.org, home

Gene · 5029

P2RY2: purinergic receptor P2Y2

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. P2RY2: purinergic receptor P2Y2. Genes, record 5029. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5029

On this page

Gene

Symbol
P2RY2
HGNC
Name
purinergic receptor P2Y2
HGNC
NCBI Gene ID
5029
NCBI Gene
HGNC ID
HGNC:8541
HGNC
Ensembl
ENSG00000175591
NCBI Gene
Aliases
HP2U, P2RU1, P2U, P2U1, P2UR, P2Y2, P2Y2R
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P41231P2Y purinoceptor 23773Ensembl, GeneID, HGNC

Source UniProt

Patents27

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1460486P41231Espacenet
JP 2026004568 A2026-01-1460487P41231Espacenet
JP 2026004568 A2026-01-1460488P41231Espacenet
JP 2025529142 A2025-09-043325P41231Espacenet
US 12371689 B22025-07-293325P41231Espacenet
JP 2022545558 A2022-10-2717P41231Espacenet
US 11446398 B22022-09-2070049P41231Espacenet
US 11446398 B22022-09-2070050P41231Espacenet
US 11446398 B22022-09-2070051P41231Espacenet
JP 2022524081 A2022-04-27173020P41231Espacenet

1 to 10 of 27

See all 27 patents

Drugs4

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
DENUFOSOLCHEMBL507282Purinergic receptor P2Y2 agonistAGONISTChEMBL
DENUFOSOL TETRASODIUMCHEMBL1767407Purinergic receptor P2Y2 agonistAGONISTChEMBL
DIQUAFOSOLCHEMBL221326Purinergic receptor P2Y2 agonistAGONISTChEMBL
DIQUAFOSOL TETRASODIUMCHEMBL1767408Purinergic receptor P2Y2 agonistAGONISTChEMBL

Trials32

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07122635DIQUAFOSOL TETRASODIUMClinicalTrials.gov
NCT07097922DIQUAFOSOL TETRASODIUMClinicalTrials.gov
NCT06903884DIQUAFOSOLPHASE3ClinicalTrials.gov
NCT06852105DIQUAFOSOL TETRASODIUMClinicalTrials.gov
NCT06537349DIQUAFOSOL TETRASODIUMClinicalTrials.gov
NCT05694026DIQUAFOSOL TETRASODIUMClinicalTrials.gov
NCT05193331DIQUAFOSOL TETRASODIUMClinicalTrials.gov
NCT04980144DIQUAFOSOL TETRASODIUMClinicalTrials.gov
NCT04548427DIQUAFOSOL TETRASODIUMPHASE3ClinicalTrials.gov
NCT03640351DIQUAFOSOLClinicalTrials.gov

1 to 10 of 32

See all 32 trials

NIH grants1,445

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleP2RY2 papersNewest fiscal year
ZIADK031116Development of P2Y Receptor Ligands362025
ZIADK031117Development of Drugs Acting at Adenosine Receptors102025
ZIAHD000195Intracellular Signaling In Endocrine Cells102025
ZIADK031126Computer Modeling of G Protein-Coupled Receptors92025
ZIADK031115Functionalized Congeners of Bioactive Compounds72025
P30CA068485Cancer Center Support Grant42025
P30DK065988UNC Cystic Fibrosis Research and Translation Core Center42025
R01CA124704Tubulin microtentacles in detached mammary epithelial cells42025
P30CA010815Consolidated Basic Cancer Research Program32025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant32025

1 to 10 of 1,445Source NIH's project files

See all 1,445 nih grants

Papers2,260

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
P2Y2 Receptor Controls TLR3-Induced Chemokine Production in Intestinal Epithelial Cells.J Immunol Res202642670086PubTator, text miningPubMed
Construction and validation of a nomogram for the diagnosis of postmenopausal osteoporosis.Mol Med Rep202642596822PubTator, text miningPubMed
Discovery of uracil-based antagonists and fluorescent ligands of the P2Y2 receptor.Eur J Med Chem202642566882PubTator, text miningPubMed
Circulating PANX1, P2RY2, and TLR3 Profiles in Gastric Cancer: A Preliminary Molecular Study.Int J Mol Sci202642511836PubTator, text miningPubMed
Adenosine triphosphate regulates metastatic behaviors of oral squamous cell carcinoma cells.Sci Rep202642477432PubTator, text miningPubMed
Liver Fibrosis and Purinergic Signaling: Autocrine-Paracrine Role of ATP in Liver Damage.Int J Mol Sci202642450299PubTator, text miningPubMed
Danger fuels immune escape.Immunity202642447847PubTator, text miningPubMed
Extracellular ATP-P2RY2 signaling drives intratumoral prostaglandin E2 accumulation and adaptive resistance to immunotherapy in solid tumors.Immunity202642392075PubTator, text miningPubMed
Uncovering G Protein-Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis.Ann Clin Transl Neurol202642163039PubTator, text miningPubMed
The Piezo1-Ca2+-PI3k/Akt signaling axis as a context-dependent mechanotransduction node during skin wound healing.iScience202642063549PubTator, text miningPubMed

1 to 10 of 2,260

See all 2,260 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5029

GET https://conductscience.org/api/genes/v1/5029/patents?page=2