Gene · 5031
P2RY6: pyrimidinergic receptor P2Y6
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. P2RY6: pyrimidinergic receptor P2Y6. Genes, record 5031. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5031
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q15077 | P2Y purinoceptor 6 | 328 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents83
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 60524 | Q15077 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 60525 | Q15077 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 60526 | Q15077 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 60527 | Q15077 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 60529 | Q15077 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 60530 | Q15077 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 60531 | Q15077 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 60532 | Q15077 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 3327 | Q15077 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 3327 | Q15077 | Espacenet |
1 to 10 of 83
See all 83 patentsDrugs2
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
Trials23
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07122635 | DIQUAFOSOL TETRASODIUM | ClinicalTrials.gov | ||
| NCT07097922 | DIQUAFOSOL TETRASODIUM | ClinicalTrials.gov | ||
| NCT06903884 | DIQUAFOSOL | PHASE3 | ClinicalTrials.gov | |
| NCT06852105 | DIQUAFOSOL TETRASODIUM | ClinicalTrials.gov | ||
| NCT06537349 | DIQUAFOSOL TETRASODIUM | ClinicalTrials.gov | ||
| NCT05694026 | DIQUAFOSOL TETRASODIUM | ClinicalTrials.gov | ||
| NCT05193331 | DIQUAFOSOL TETRASODIUM | ClinicalTrials.gov | ||
| NCT04980144 | DIQUAFOSOL TETRASODIUM | ClinicalTrials.gov | ||
| NCT04548427 | DIQUAFOSOL TETRASODIUM | PHASE3 | ClinicalTrials.gov | |
| NCT03640351 | DIQUAFOSOL | ClinicalTrials.gov |
1 to 10 of 23
See all 23 trialsNIH grants595
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | P2RY6 papers | Newest fiscal year |
|---|---|---|---|
| ZIADK031116 | Development of P2Y Receptor Ligands | 34 | 2025 |
| ZIADK031117 | Development of Drugs Acting at Adenosine Receptors | 10 | 2025 |
| ZIADK031126 | Computer Modeling of G Protein-Coupled Receptors | 8 | 2025 |
| ZIADK031115 | Functionalized Congeners of Bioactive Compounds | 7 | 2025 |
| R01AI078908 | Control of Pulmonary Inflammation by Leukotriene E4 | 3 | 2025 |
| R35NS132326 | How microglia sense and regulate neuronal activity in the adult brain | 3 | 2025 |
| R01CA124704 | Tubulin microtentacles in detached mammary epithelial cells | 2 | 2025 |
| R01DK057236 | Electrophysiological Events Underlying Human Gastric Motility. | 2 | 2025 |
| R01DK064324 | Multiphoton imaging of the juxtaglomerular apparatus | 2 | 2025 |
| R01DK103723 | Regulation of enteric motor neurocircuits by enteric glia in health and disease | 2 | 2025 |
1 to 10 of 595Source NIH's project files
See all 595 nih grantsPapers1,201
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Microglia calcium signals drive fine process retraction and promote susceptibility to status epilepticus. | Cell Calcium | 2026 | 42822103 | PubTator, text mining | PubMed |
| COPI Coatomer Regulates Several Steps of HDL Metabolism. | Arterioscler Thromb Vasc Biol | 2026 | 42592650 | PubTator, text mining | PubMed |
| Liver Fibrosis and Purinergic Signaling: Autocrine-Paracrine Role of ATP in Liver Damage. | Int J Mol Sci | 2026 | 42450299 | PubTator, text mining | PubMed |
| Inhibition of (interstitial) P2Y6 receptors attenuates fibrosis progression. | Pflugers Arch | 2026 | 42303751 | PubTator, text mining | PubMed |
| P2RY6+ tumor-associated macrophages as a therapeutic target: suppressing tumor growth and enhancing chemosensitivity in triple-negative breast cancer. | Cell Oncol (Dordr) | 2026 | 42250059 | PubTator, text mining | PubMed |
| Inhibition of (interstitial) P2Y6 receptors attenuates fibrosis progression. | Res Sq | 2026 | 41960339 | PubTator, text mining | PubMed |
| Integrating Transcriptomics and 3D Spheroid Models Reveals Microenvironment-Dependent Purinergic Modulation in Hepatocellular Carcinoma. | Metabolites | 2026 | 41893304 | PubTator, text mining | PubMed |
| Distinct P2 receptors initiate intracellular signaling involved in mechanotransduction in tenocytes. | Am J Physiol Cell Physiol | 2026 | 41811693 | PubTator, text mining | PubMed |
| Regulatory roles of bioactive lipids in vascular homeostasis and remodeling. | Med Rev (2021) | 2026 | 41783891 | PubTator, text mining | PubMed |
| SNRPD2-mediated regulation of DDX39B splicing promotes endometrial cancer progression by suppressing the activation of CTSC cryptic exons. | Cell Death Dis | 2026 | 41720762 | PubTator, text mining | PubMed |
1 to 10 of 1,201
See all 1,201 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/5031
GET https://conductscience.org/api/genes/v1/5031/patents?page=2