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Gene · 5031

P2RY6: pyrimidinergic receptor P2Y6

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. P2RY6: pyrimidinergic receptor P2Y6. Genes, record 5031. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5031

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Gene

Symbol
P2RY6
HGNC
Name
pyrimidinergic receptor P2Y6
HGNC
NCBI Gene ID
5031
NCBI Gene
HGNC ID
HGNC:8543
HGNC
Ensembl
ENSG00000171631
NCBI Gene
Aliases
P2Y6
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q15077P2Y purinoceptor 63280Ensembl, GeneID, HGNC

Source UniProt

Patents83

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1460524Q15077Espacenet
JP 2026004568 A2026-01-1460525Q15077Espacenet
JP 2026004568 A2026-01-1460526Q15077Espacenet
JP 2026004568 A2026-01-1460527Q15077Espacenet
JP 2026004568 A2026-01-1460529Q15077Espacenet
JP 2026004568 A2026-01-1460530Q15077Espacenet
JP 2026004568 A2026-01-1460531Q15077Espacenet
JP 2026004568 A2026-01-1460532Q15077Espacenet
JP 2025529142 A2025-09-043327Q15077Espacenet
US 12371689 B22025-07-293327Q15077Espacenet

1 to 10 of 83

See all 83 patents

Drugs2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
DIQUAFOSOLCHEMBL221326Pyrimidinergic receptor P2Y6 agonistAGONISTChEMBL
DIQUAFOSOL TETRASODIUMCHEMBL1767408Pyrimidinergic receptor P2Y6 agonistAGONISTChEMBL

Trials23

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07122635DIQUAFOSOL TETRASODIUMClinicalTrials.gov
NCT07097922DIQUAFOSOL TETRASODIUMClinicalTrials.gov
NCT06903884DIQUAFOSOLPHASE3ClinicalTrials.gov
NCT06852105DIQUAFOSOL TETRASODIUMClinicalTrials.gov
NCT06537349DIQUAFOSOL TETRASODIUMClinicalTrials.gov
NCT05694026DIQUAFOSOL TETRASODIUMClinicalTrials.gov
NCT05193331DIQUAFOSOL TETRASODIUMClinicalTrials.gov
NCT04980144DIQUAFOSOL TETRASODIUMClinicalTrials.gov
NCT04548427DIQUAFOSOL TETRASODIUMPHASE3ClinicalTrials.gov
NCT03640351DIQUAFOSOLClinicalTrials.gov

1 to 10 of 23

See all 23 trials

NIH grants595

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleP2RY6 papersNewest fiscal year
ZIADK031116Development of P2Y Receptor Ligands342025
ZIADK031117Development of Drugs Acting at Adenosine Receptors102025
ZIADK031126Computer Modeling of G Protein-Coupled Receptors82025
ZIADK031115Functionalized Congeners of Bioactive Compounds72025
R01AI078908Control of Pulmonary Inflammation by Leukotriene E432025
R35NS132326How microglia sense and regulate neuronal activity in the adult brain32025
R01CA124704Tubulin microtentacles in detached mammary epithelial cells22025
R01DK057236Electrophysiological Events Underlying Human Gastric Motility.22025
R01DK064324Multiphoton imaging of the juxtaglomerular apparatus22025
R01DK103723Regulation of enteric motor neurocircuits by enteric glia in health and disease22025

1 to 10 of 595Source NIH's project files

See all 595 nih grants

Papers1,201

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Microglia calcium signals drive fine process retraction and promote susceptibility to status epilepticus.Cell Calcium202642822103PubTator, text miningPubMed
COPI Coatomer Regulates Several Steps of HDL Metabolism.Arterioscler Thromb Vasc Biol202642592650PubTator, text miningPubMed
Liver Fibrosis and Purinergic Signaling: Autocrine-Paracrine Role of ATP in Liver Damage.Int J Mol Sci202642450299PubTator, text miningPubMed
Inhibition of (interstitial) P2Y6 receptors attenuates fibrosis progression.Pflugers Arch202642303751PubTator, text miningPubMed
P2RY6+ tumor-associated macrophages as a therapeutic target: suppressing tumor growth and enhancing chemosensitivity in triple-negative breast cancer.Cell Oncol (Dordr)202642250059PubTator, text miningPubMed
Inhibition of (interstitial) P2Y6 receptors attenuates fibrosis progression.Res Sq202641960339PubTator, text miningPubMed
Integrating Transcriptomics and 3D Spheroid Models Reveals Microenvironment-Dependent Purinergic Modulation in Hepatocellular Carcinoma.Metabolites202641893304PubTator, text miningPubMed
Distinct P2 receptors initiate intracellular signaling involved in mechanotransduction in tenocytes.Am J Physiol Cell Physiol202641811693PubTator, text miningPubMed
Regulatory roles of bioactive lipids in vascular homeostasis and remodeling.Med Rev (2021)202641783891PubTator, text miningPubMed
SNRPD2-mediated regulation of DDX39B splicing promotes endometrial cancer progression by suppressing the activation of CTSC cryptic exons.Cell Death Dis202641720762PubTator, text miningPubMed

1 to 10 of 1,201

See all 1,201 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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