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Gene · 51366

UBR5: ubiquitin protein ligase E3 component n-recognin 5

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. UBR5: ubiquitin protein ligase E3 component n-recognin 5. Genes, record 51366. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/51366

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Gene

Symbol
UBR5
HGNC
Name
ubiquitin protein ligase E3 component n-recognin 5
HGNC
NCBI Gene ID
51366
NCBI Gene
HGNC ID
HGNC:16806
HGNC
Ensembl
ENSG00000104517
NCBI Gene
Aliases
DD5, EDD, EDD1, HYD, KIAA0896, NEDSBH
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O95071E3 ubiquitin-protein ligase UBR52,79911Ensembl, GeneID, HGNC

Source UniProt

Patents28

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026507518 A2026-03-04153O95071Espacenet
EP 4665771 A12025-12-24153O95071Espacenet
EP 4641201 A22025-10-2918096O95071Espacenet
JP 2025517969 A2025-06-1218096O95071Espacenet
JP 2022141755 A2022-09-29195O95071Espacenet
US 11446398 B22022-09-2094641O95071Espacenet
JP 2022524081 A2022-04-27197612O95071Espacenet
WO 2020043864 A12020-03-052744O95071Espacenet
US 10302646 B22019-05-28117O95071Espacenet
JP 2019033757 A2019-03-0724895O95071Espacenet

1 to 10 of 28

See all 28 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,184

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleUBR5 papersNewest fiscal year
P30CA016672Cancer Center Support Grant132025
P30CA008748Cancer Center Support Grant102025
P30CA006927Comprehensive Cancer Center Program at Fox Chase52025
P30CA021765Cancer Center Support Grant (CCSG)42025
P30CA076292Moffitt Cancer Center Support Grant42025
R01DK039520New Mechanisms and Functions of the Pro/N Degron and Arg/N-Degron Pathways42025
R01GM031530Superchanneling, Regulation of Caspases, and Site-Specific Control of RNA42025
P20GM121316Nebraska Center for Molecular Target Discovery and Development32025
P30CA016056Roswell Park Cancer Center Support Grant32025
P30CA016086Cancer Center Support Grant32025

1 to 10 of 1,184Source NIH's project files

See all 1,184 nih grants

Papers1,630

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
UBR5-KDM5A axis rewires redox metabolism to confer cisplatin resistance in triple-negative breast cancer via the cAMP-PKA-SIRT3 cascade.Drug Resist Updat202642809895PubTator, text miningPubMed
JNK acts as a molecular brake of the CDC73 positive feedback loop to modulate osteosarcoma malignant progression via UBR5.Oncogene202642749759PubTator, text miningPubMed
Dynamic Prediction of Survival Outcomes in Multiple Myeloma.Cancers (Basel)202642738384PubTator, text miningPubMed
Correction to: UBR-box containing protein, UBR5, is overexpressed in human lung adenocarcinoma and is a potential therapeutic target.BMC Cancer202642717320PubTator, text miningPubMed
UV-B enhances hyperaccumulation of α- and β-carotene in marigold petals.Plant Physiol Biochem202642526340PubTator, text miningPubMed
Mechanistic and functional study of lncRNA SNHG3/miR-128-3p/UBR5 axis in neuroinflammation in Alzheimer's disease.J Gerontol A Biol Sci Med Sci202642502987PubTator, text miningPubMed
Pan-cancer proteogenomic interrogation of the ubiquitin-proteasome system.Cell Death Differ202642472879PubTator, text miningPubMed
Network pharmacology combined with molecular docking to investigate the potential role of curcumin targeting TGR5 to modulate the GLP-1 pathway in T2DM with obesity.Pak J Pharm Sci202642433074PubTator, text miningPubMed
Distinct Proteasomal Pathways Drive Oncogenic PPM1D Activation.bioRxiv202642282570PubTator, text miningPubMed
Defining a Novel 8q22.3 Microdeletion Syndrome Caused by UBR5 Haploinsufficiency.Pediatr Neurol202642263457PubTator, text miningPubMed

1 to 10 of 1,630

See all 1,630 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/51366

GET https://conductscience.org/api/genes/v1/51366/patents?page=2