Gene · 5137
PDE1C: phosphodiesterase 1C
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. PDE1C: phosphodiesterase 1C. Genes, record 5137. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5137
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q14123 | Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C | 709 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents36
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 57700 | Q14123 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 57704 | Q14123 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 5160 | Q14123 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 4751 | Q14123 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 4751 | Q14123 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 5160 | Q14123 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 33148 | Q14123 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 33149 | Q14123 | Espacenet |
| JP 2025004127 A | 2025-01-14 | 5 | Q14123 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 33148 | Q14123 | Espacenet |
1 to 10 of 36
See all 36 patentsDrugs2
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
Trials135
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07349472 | PENTOXIFYLLINE | PHASE2 | ClinicalTrials.gov | |
| NCT07315139 | PENTOXIFYLLINE | ClinicalTrials.gov | ||
| NCT07252518 | PENTOXIFYLLINE | ClinicalTrials.gov | ||
| NCT07199504 | DIPYRIDAMOLE | PHASE2/PHASE3 | ClinicalTrials.gov | |
| NCT07088328 | PENTOXIFYLLINE | ClinicalTrials.gov | ||
| NCT07086794 | PENTOXIFYLLINE | EARLY_PHASE1 | ClinicalTrials.gov | |
| NCT07085806 | PENTOXIFYLLINE | ClinicalTrials.gov | ||
| NCT06998628 | PENTOXIFYLLINE | PHASE2 | ClinicalTrials.gov | |
| NCT06986031 | PENTOXIFYLLINE | PHASE2 | ClinicalTrials.gov | |
| NCT06912763 | PENTOXIFYLLINE | PHASE2 | ClinicalTrials.gov |
1 to 10 of 135
See all 135 trialsNIH grants438
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | PDE1C papers | Newest fiscal year |
|---|---|---|---|
| T32HL007227 | Pathophysiology of Myocardial Disease | 7 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 2 | 2025 |
| I01BX004024 | Transport and metabolism in the kidney | 1 | 2025 |
| P30CA016087 | Cancer Center Support Grant | 1 | 2025 |
| P30DK020572 | Michigan Diabetes Research Center (MDRC) | 1 | 2025 |
| P30DK020579 | Diabetes Research Center | 1 | 2025 |
| P30DK063491 | Diabetes Research Center (DRC) | 1 | 2025 |
| P30ES005605 | Environmental Health Sciences Research Center | 1 | 2025 |
| P30ES007033 | University of Washington Interdisciplinary Center for Exposures, Diseases, Genomics & Environment | 1 | 2025 |
| P30ES010126 | UNC Center for Environmental Health and Susceptibility | 1 | 2025 |
1 to 10 of 438Source NIH's project files
See all 438 nih grantsPapers468
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Inhibitors of phosphodiesterase 1 enhance paclitaxel cytotoxicity in a MDA-MB-231-derived cell line by promoting microtubule stabilization. | BBA Adv | 2026 | 42004461 | PubTator, text mining | PubMed |
| Clinical and Functional Characterization of PDE1A as a Wnt/β-Catenin-Linked Biomarker of Progression and Platinum Resistance in Epithelial Ovarian Cancer. | Oncol Res | 2026 | 41799512 | PubTator, text mining | PubMed |
| Biological implications and therapeutic potential of phosphodiesterase inhibitors: A review. | Medicine (Baltimore) | 2026 | 41790675 | PubTator, text mining | PubMed |
| Phosphodiesterase inhibitors as emerging therapeutics for skeletal disorders: A comprehensive review of mechanisms and repurposing potential. | Bone Rep | 2026 | 41732176 | PubTator, text mining | PubMed |
| Allele-specific alternative polyadenylation links noncoding genetic variation to Alzheimer's disease risk. | bioRxiv | 2026 | 41726974 | PubTator, text mining | PubMed |
| Preliminary Evidence of Blood DNA Methylation Changes in Pregnant Women Adhering to a Mediterranean Diet. | Epigenomes | 2026 | 41718410 | PubTator, text mining | PubMed |
| Identification and Validation of FOXK1-Related Biomarkers in Diabetic Retinopathy. | Int J Gen Med | 2026 | 41716682 | PubTator, text mining | PubMed |
| Needle-in-a-haystack approach: rapid screening of PDE1C inhibitors through the combination of machine learning, molecular docking, molecular dynamics simulations and experimental validation. | J Comput Aided Mol Des | 2025 | 41460364 | PubTator, text mining | PubMed |
| Cyclic nucleotide phosphodiesterase 1 and cognitive impairment: Mechanistic insights and therapeutic implications. | Biomed Pharmacother | 2025 | 41273928 | PubTator, text mining | PubMed |
| The Molecular Mechanism of PDE1 Regulation. | Cells | 2025 | 41227367 | PubTator, text mining | PubMed |
1 to 10 of 468
See all 468 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/5137
GET https://conductscience.org/api/genes/v1/5137/patents?page=2