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Gene · 5138

PDE2A: phosphodiesterase 2A

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PDE2A: phosphodiesterase 2A. Genes, record 5138. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5138

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Gene

Symbol
PDE2A
HGNC
Name
phosphodiesterase 2A
HGNC
NCBI Gene ID
5138
NCBI Gene
HGNC ID
HGNC:8777
HGNC
Ensembl
ENSG00000186642
NCBI Gene
Aliases
CGS-PDE, IDDPADS, PDE2A1, PED2A4, cGSPDE
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O00408cGMP-dependent 3',5'-cyclic phosphodiesterase94144Ensembl, GeneID, HGNC

Source UniProt

Patents56

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2025147176 A2025-10-0610149O00408Espacenet
JP 2025529142 A2025-09-047300O00408Espacenet
US 12371689 B22025-07-297300O00408Espacenet
JP 2025028160 A2025-02-2810149O00408Espacenet
KR 1020250010750 A2025-01-2110149O00408Espacenet
JP 2025004127 A2025-01-146O00408Espacenet
WO 2024240908 A12024-11-285O00408Espacenet
JP 2024109657 A2024-08-1410156O00408Espacenet
JP 2023144094 A2023-10-06113O00408Espacenet
US 11666642 B22023-06-06113O00408Espacenet

1 to 10 of 56

See all 56 patents

Drugs2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
DIPYRIDAMOLECHEMBL9323',5'-cyclic phosphodiesterase inhibitorINHIBITORChEMBL
PENTOXIFYLLINECHEMBL6283',5'-cyclic phosphodiesterase inhibitorINHIBITORChEMBL

Trials135

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07349472PENTOXIFYLLINEPHASE2ClinicalTrials.gov
NCT07315139PENTOXIFYLLINEClinicalTrials.gov
NCT07252518PENTOXIFYLLINEClinicalTrials.gov
NCT07199504DIPYRIDAMOLEPHASE2/PHASE3ClinicalTrials.gov
NCT07088328PENTOXIFYLLINEClinicalTrials.gov
NCT07086794PENTOXIFYLLINEEARLY_PHASE1ClinicalTrials.gov
NCT07085806PENTOXIFYLLINEClinicalTrials.gov
NCT06998628PENTOXIFYLLINEPHASE2ClinicalTrials.gov
NCT06986031PENTOXIFYLLINEPHASE2ClinicalTrials.gov
NCT06912763PENTOXIFYLLINEPHASE2ClinicalTrials.gov

1 to 10 of 135

See all 135 trials

NIH grants425

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePDE2A papersNewest fiscal year
P30DK063491Diabetes Research Center (DRC)42025
P30CA013148Comprehensive Cancer Center Support Grant32025
P30CA015083Mayo Clinic Comprehensive Cancer Center Support Grant22025
P30CA016672Cancer Center Support Grant22025
P30ES007048Environmental Exposures, Host Factors and Human Disease22025
R01AG070873Role of PDE2A in mitochondrial dysfunction in Alzheimer’s disease22025
R01HL058506G Protein-Coupled Receptor Regulation in Airway Myocytes22025
T32HL007227Pathophysiology of Myocardial Disease22025
F30OD031914MicroRNA-375 regulation of enteroendocrine cell biology in diet-induced obesity and bariatric surgery12025
I01BX004024Transport and metabolism in the kidney12025

1 to 10 of 425Source NIH's project files

See all 425 nih grants

Papers739

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
A Mitochondrial-Related Gene Signature for Diagnosis and Immune Microenvironment Modulation in Lung Cancer and Venous Thromboembolism.World J Oncol202642730163PubTator, text miningPubMed
Atrial Natriuretic Peptide Regulates Zona Glomerulosa Growth and Aldosterone Release.Hypertension202642717871PubTator, text miningPubMed
Mitochondrial NCLX couples glucagon- and PDE2A-Dependent signals to regulate hepatic lipid metabolism.Mol Metab202642641876PubTator, text miningPubMed
Elevated LncRNALINC00966 Suppresses PDE2A to Impair Sperm Motility in Asthenozoospermia.FASEB Bioadv202642569623PubTator, text miningPubMed
Mitochondrial calcium regulates lipid metabolism by modulating tethering of mitochondria to lipid droplets.EMBO J202642399516PubTator, text miningPubMed
Prognostic Genes Linked to Asparagine Metabolism in Hepatocellular Carcinoma: Identification, Validation, and Regulatory Mechanisms Based on Transcriptome and Single-Cell RNA Sequencing.Int J Mol Sci202642196419PubTator, text miningPubMed
Gene expression meta-analysis in the prefrontal cortex: unraveling biological underpinnings of suicidal risk.BMC Psychiatry202642163165PubTator, text miningPubMed
Atrial natriuretic peptide counteracts aldosterone secretion by preventing acute angiotensin II-induced cAMP signalling.Br J Pharmacol202642116793PubTator, text miningPubMed
EXOSC5 Promotes PDE2A mRNA Degradation and Activates the cGMP-PKG Pathway to Drive Non-Small Cell Lung Cancer Progression.Tohoku J Exp Med202641922217PubTator, text miningPubMed
Metabolic profiling of the TME uncovers the contrasting impacts of CKMT2 and PDE2A in CRC progression and therapeutic response.Front Pharmacol202641878336PubTator, text miningPubMed

1 to 10 of 739

See all 739 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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