Gene · 5138
PDE2A: phosphodiesterase 2A
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. PDE2A: phosphodiesterase 2A. Genes, record 5138. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5138
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O00408 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 941 | 44 | Ensembl, GeneID, HGNC |
Source UniProt
Patents56
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2025147176 A | 2025-10-06 | 10149 | O00408 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 7300 | O00408 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 7300 | O00408 | Espacenet |
| JP 2025028160 A | 2025-02-28 | 10149 | O00408 | Espacenet |
| KR 1020250010750 A | 2025-01-21 | 10149 | O00408 | Espacenet |
| JP 2025004127 A | 2025-01-14 | 6 | O00408 | Espacenet |
| WO 2024240908 A1 | 2024-11-28 | 5 | O00408 | Espacenet |
| JP 2024109657 A | 2024-08-14 | 10156 | O00408 | Espacenet |
| JP 2023144094 A | 2023-10-06 | 113 | O00408 | Espacenet |
| US 11666642 B2 | 2023-06-06 | 113 | O00408 | Espacenet |
1 to 10 of 56
See all 56 patentsDrugs2
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
Trials135
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07349472 | PENTOXIFYLLINE | PHASE2 | ClinicalTrials.gov | |
| NCT07315139 | PENTOXIFYLLINE | ClinicalTrials.gov | ||
| NCT07252518 | PENTOXIFYLLINE | ClinicalTrials.gov | ||
| NCT07199504 | DIPYRIDAMOLE | PHASE2/PHASE3 | ClinicalTrials.gov | |
| NCT07088328 | PENTOXIFYLLINE | ClinicalTrials.gov | ||
| NCT07086794 | PENTOXIFYLLINE | EARLY_PHASE1 | ClinicalTrials.gov | |
| NCT07085806 | PENTOXIFYLLINE | ClinicalTrials.gov | ||
| NCT06998628 | PENTOXIFYLLINE | PHASE2 | ClinicalTrials.gov | |
| NCT06986031 | PENTOXIFYLLINE | PHASE2 | ClinicalTrials.gov | |
| NCT06912763 | PENTOXIFYLLINE | PHASE2 | ClinicalTrials.gov |
1 to 10 of 135
See all 135 trialsNIH grants425
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | PDE2A papers | Newest fiscal year |
|---|---|---|---|
| P30DK063491 | Diabetes Research Center (DRC) | 4 | 2025 |
| P30CA013148 | Comprehensive Cancer Center Support Grant | 3 | 2025 |
| P30CA015083 | Mayo Clinic Comprehensive Cancer Center Support Grant | 2 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 2 | 2025 |
| P30ES007048 | Environmental Exposures, Host Factors and Human Disease | 2 | 2025 |
| R01AG070873 | Role of PDE2A in mitochondrial dysfunction in Alzheimer’s disease | 2 | 2025 |
| R01HL058506 | G Protein-Coupled Receptor Regulation in Airway Myocytes | 2 | 2025 |
| T32HL007227 | Pathophysiology of Myocardial Disease | 2 | 2025 |
| F30OD031914 | MicroRNA-375 regulation of enteroendocrine cell biology in diet-induced obesity and bariatric surgery | 1 | 2025 |
| I01BX004024 | Transport and metabolism in the kidney | 1 | 2025 |
1 to 10 of 425Source NIH's project files
See all 425 nih grantsPapers739
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| A Mitochondrial-Related Gene Signature for Diagnosis and Immune Microenvironment Modulation in Lung Cancer and Venous Thromboembolism. | World J Oncol | 2026 | 42730163 | PubTator, text mining | PubMed |
| Atrial Natriuretic Peptide Regulates Zona Glomerulosa Growth and Aldosterone Release. | Hypertension | 2026 | 42717871 | PubTator, text mining | PubMed |
| Mitochondrial NCLX couples glucagon- and PDE2A-Dependent signals to regulate hepatic lipid metabolism. | Mol Metab | 2026 | 42641876 | PubTator, text mining | PubMed |
| Elevated LncRNALINC00966 Suppresses PDE2A to Impair Sperm Motility in Asthenozoospermia. | FASEB Bioadv | 2026 | 42569623 | PubTator, text mining | PubMed |
| Mitochondrial calcium regulates lipid metabolism by modulating tethering of mitochondria to lipid droplets. | EMBO J | 2026 | 42399516 | PubTator, text mining | PubMed |
| Prognostic Genes Linked to Asparagine Metabolism in Hepatocellular Carcinoma: Identification, Validation, and Regulatory Mechanisms Based on Transcriptome and Single-Cell RNA Sequencing. | Int J Mol Sci | 2026 | 42196419 | PubTator, text mining | PubMed |
| Gene expression meta-analysis in the prefrontal cortex: unraveling biological underpinnings of suicidal risk. | BMC Psychiatry | 2026 | 42163165 | PubTator, text mining | PubMed |
| Atrial natriuretic peptide counteracts aldosterone secretion by preventing acute angiotensin II-induced cAMP signalling. | Br J Pharmacol | 2026 | 42116793 | PubTator, text mining | PubMed |
| EXOSC5 Promotes PDE2A mRNA Degradation and Activates the cGMP-PKG Pathway to Drive Non-Small Cell Lung Cancer Progression. | Tohoku J Exp Med | 2026 | 41922217 | PubTator, text mining | PubMed |
| Metabolic profiling of the TME uncovers the contrasting impacts of CKMT2 and PDE2A in CRC progression and therapeutic response. | Front Pharmacol | 2026 | 41878336 | PubTator, text mining | PubMed |
1 to 10 of 739
See all 739 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/5138
GET https://conductscience.org/api/genes/v1/5138/patents?page=2