Gene · 5145
PDE6A: phosphodiesterase 6A
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. PDE6A: phosphodiesterase 6A. Genes, record 5145. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5145
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P16499 | Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha | 860 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents50
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026515744 A | 2026-05-19 | 118 | P16499 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 57754 | P16499 | Espacenet |
| EP 4667578 A2 | 2025-12-24 | 170 | P16499 | Espacenet |
| EP 4667578 A2 | 2025-12-24 | 172 | P16499 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 1155 | P16499 | Espacenet |
| JP 2025131621 A | 2025-09-09 | 170 | P16499 | Espacenet |
| JP 2025131621 A | 2025-09-09 | 172 | P16499 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 1155 | P16499 | Espacenet |
| US 12310997 B2 | 2025-05-27 | 102 | P16499 | Espacenet |
| US 12246072 B2 | 2025-03-11 | 26 | P16499 | Espacenet |
1 to 10 of 50
See all 50 patentsDrugs2
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
Trials135
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07349472 | PENTOXIFYLLINE | PHASE2 | ClinicalTrials.gov | |
| NCT07315139 | PENTOXIFYLLINE | ClinicalTrials.gov | ||
| NCT07252518 | PENTOXIFYLLINE | ClinicalTrials.gov | ||
| NCT07199504 | DIPYRIDAMOLE | PHASE2/PHASE3 | ClinicalTrials.gov | |
| NCT07088328 | PENTOXIFYLLINE | ClinicalTrials.gov | ||
| NCT07086794 | PENTOXIFYLLINE | EARLY_PHASE1 | ClinicalTrials.gov | |
| NCT07085806 | PENTOXIFYLLINE | ClinicalTrials.gov | ||
| NCT06998628 | PENTOXIFYLLINE | PHASE2 | ClinicalTrials.gov | |
| NCT06986031 | PENTOXIFYLLINE | PHASE2 | ClinicalTrials.gov | |
| NCT06912763 | PENTOXIFYLLINE | PHASE2 | ClinicalTrials.gov |
1 to 10 of 135
See all 135 trialsNIH grants316
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | PDE6A papers | Newest fiscal year |
|---|---|---|---|
| R01EY010843 | Regulation of Retinal cGMP-Phosphodiesterases | 14 | 2025 |
| R01EY018213 | Defining Barriers to Gene Therapy | 14 | 2025 |
| P30CA013696 | Cancer Center Support Grant | 7 | 2025 |
| R01EY024698 | Gene Editing and Silencing in Phototransduction | 6 | 2025 |
| P30EY014104 | P30 Core Grant for Vision Research | 4 | 2025 |
| P30EY014800 | University of Utah Core Vision Research Grant | 4 | 2025 |
| R01EY018571 | Genetics of early onset retinal diseases | 4 | 2025 |
| ZIAEY000272 | Inherited Ocular Diseases | 4 | 2025 |
| P20GM113131 | Center of Integrated Biomedical and Bioengineering Research (CIBBR) | 3 | 2025 |
| P30EY000331 | Vision Research Core at UCLA | 3 | 2025 |
1 to 10 of 316Source NIH's project files
See all 316 nih grantsPapers571
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Clinical manifestations of dual-gene variants in retinitis pigmentosa. | Acta Ophthalmol | 2026 | 42360046 | PubTator, text mining | PubMed |
| A highly dynamic active state for transducin-bound phosphodiesterase-6 in vertebrate phototransduction. | bioRxiv | 2026 | 41959389 | PubTator, text mining | PubMed |
| Biological implications and therapeutic potential of phosphodiesterase inhibitors: A review. | Medicine (Baltimore) | 2026 | 41790675 | PubTator, text mining | PubMed |
| Nonsense Mutation in USH2A Exon-13 Activates the Innate Immune Response in Müller Glial Cells. | Int J Mol Sci | 2026 | 41751772 | PubTator, text mining | PubMed |
| Diagnostic Role of Chromatic Full-Field Stimulus Test in Rod-Cone Versus Cone Dystrophies. | Biomedicines | 2026 | 41751276 | PubTator, text mining | PubMed |
| Clinical and Molecular Characteristics of Foveal Sparing Phenotype in Chinese Patients With Inherited Retinal Diseases. | Transl Vis Sci Technol | 2026 | 41700794 | PubTator, text mining | PubMed |
| Coupled polyphosphate storage and DOP mobilization along estuarine gradients in the Pearl River Estuary. | Mar Pollut Bull | 2026 | 41037945 | PubTator, text mining | PubMed |
| Safety and vision outcomes of subretinal gene supplementation therapy in PDE6A-associated retinitis pigmentosa: a non-randomised controlled trial. | Br J Ophthalmol | 2026 | 40825661 | PubTator, text mining | PubMed |
| Genetic Spectrum of Negative Electroretinograms in a Predominantly Pediatric Cohort of 177 Patients. | Invest Ophthalmol Vis Sci | 2025 | 41342616 | PubTator, text mining | PubMed |
| Identification of metabolism regulators as diagnostic markers for ulcerative colitis and their correlation with immune infiltration. | Pol J Pathol | 2025 | 40977549 | PubTator, text mining | PubMed |
1 to 10 of 571
See all 571 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/5145
GET https://conductscience.org/api/genes/v1/5145/patents?page=2