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Gene · 5145

PDE6A: phosphodiesterase 6A

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PDE6A: phosphodiesterase 6A. Genes, record 5145. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5145

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Gene

Symbol
PDE6A
HGNC
Name
phosphodiesterase 6A
HGNC
NCBI Gene ID
5145
NCBI Gene
HGNC ID
HGNC:8785
HGNC
Ensembl
ENSG00000132915
NCBI Gene
Aliases
CGPR-A, PDEA, RP43
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P16499Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha8600Ensembl, GeneID, HGNC

Source UniProt

Patents50

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026515744 A2026-05-19118P16499Espacenet
JP 2026004568 A2026-01-1457754P16499Espacenet
EP 4667578 A22025-12-24170P16499Espacenet
EP 4667578 A22025-12-24172P16499Espacenet
EP 4641201 A22025-10-291155P16499Espacenet
JP 2025131621 A2025-09-09170P16499Espacenet
JP 2025131621 A2025-09-09172P16499Espacenet
JP 2025517969 A2025-06-121155P16499Espacenet
US 12310997 B22025-05-27102P16499Espacenet
US 12246072 B22025-03-1126P16499Espacenet

1 to 10 of 50

See all 50 patents

Drugs2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
DIPYRIDAMOLECHEMBL9323',5'-cyclic phosphodiesterase inhibitorINHIBITORChEMBL
PENTOXIFYLLINECHEMBL6283',5'-cyclic phosphodiesterase inhibitorINHIBITORChEMBL

Trials135

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07349472PENTOXIFYLLINEPHASE2ClinicalTrials.gov
NCT07315139PENTOXIFYLLINEClinicalTrials.gov
NCT07252518PENTOXIFYLLINEClinicalTrials.gov
NCT07199504DIPYRIDAMOLEPHASE2/PHASE3ClinicalTrials.gov
NCT07088328PENTOXIFYLLINEClinicalTrials.gov
NCT07086794PENTOXIFYLLINEEARLY_PHASE1ClinicalTrials.gov
NCT07085806PENTOXIFYLLINEClinicalTrials.gov
NCT06998628PENTOXIFYLLINEPHASE2ClinicalTrials.gov
NCT06986031PENTOXIFYLLINEPHASE2ClinicalTrials.gov
NCT06912763PENTOXIFYLLINEPHASE2ClinicalTrials.gov

1 to 10 of 135

See all 135 trials

NIH grants316

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePDE6A papersNewest fiscal year
R01EY010843Regulation of Retinal cGMP-Phosphodiesterases142025
R01EY018213Defining Barriers to Gene Therapy142025
P30CA013696Cancer Center Support Grant72025
R01EY024698Gene Editing and Silencing in Phototransduction62025
P30EY014104P30 Core Grant for Vision Research42025
P30EY014800University of Utah Core Vision Research Grant42025
R01EY018571Genetics of early onset retinal diseases42025
ZIAEY000272Inherited Ocular Diseases42025
P20GM113131Center of Integrated Biomedical and Bioengineering Research (CIBBR)32025
P30EY000331Vision Research Core at UCLA32025

1 to 10 of 316Source NIH's project files

See all 316 nih grants

Papers571

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Clinical manifestations of dual-gene variants in retinitis pigmentosa.Acta Ophthalmol202642360046PubTator, text miningPubMed
A highly dynamic active state for transducin-bound phosphodiesterase-6 in vertebrate phototransduction.bioRxiv202641959389PubTator, text miningPubMed
Biological implications and therapeutic potential of phosphodiesterase inhibitors: A review.Medicine (Baltimore)202641790675PubTator, text miningPubMed
Nonsense Mutation in USH2A Exon-13 Activates the Innate Immune Response in Müller Glial Cells.Int J Mol Sci202641751772PubTator, text miningPubMed
Diagnostic Role of Chromatic Full-Field Stimulus Test in Rod-Cone Versus Cone Dystrophies.Biomedicines202641751276PubTator, text miningPubMed
Clinical and Molecular Characteristics of Foveal Sparing Phenotype in Chinese Patients With Inherited Retinal Diseases.Transl Vis Sci Technol202641700794PubTator, text miningPubMed
Coupled polyphosphate storage and DOP mobilization along estuarine gradients in the Pearl River Estuary.Mar Pollut Bull202641037945PubTator, text miningPubMed
Safety and vision outcomes of subretinal gene supplementation therapy in PDE6A-associated retinitis pigmentosa: a non-randomised controlled trial.Br J Ophthalmol202640825661PubTator, text miningPubMed
Genetic Spectrum of Negative Electroretinograms in a Predominantly Pediatric Cohort of 177 Patients.Invest Ophthalmol Vis Sci202541342616PubTator, text miningPubMed
Identification of metabolism regulators as diagnostic markers for ulcerative colitis and their correlation with immune infiltration.Pol J Pathol202540977549PubTator, text miningPubMed

1 to 10 of 571

See all 571 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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