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Gene · 5150

PDE7A: phosphodiesterase 7A

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PDE7A: phosphodiesterase 7A. Genes, record 5150. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5150

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Gene

Symbol
PDE7A
HGNC
Name
phosphodiesterase 7A
HGNC
NCBI Gene ID
5150
NCBI Gene
HGNC ID
HGNC:8791
HGNC
Ensembl
ENSG00000205268
NCBI Gene
Aliases
HCP1, PDE7
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q13946High affinity 3',5'-cyclic-AMP phosphodiesterase 7A4824Ensembl, GeneID, HGNC

Source UniProt

Patents47

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1457765Q13946Espacenet
EP 4641201 A22025-10-2912789Q13946Espacenet
EP 4641202 A22025-10-296076Q13946Espacenet
JP 2025147176 A2025-10-0610169Q13946Espacenet
JP 2025529142 A2025-09-047301Q13946Espacenet
US 12371689 B22025-07-297301Q13946Espacenet
JP 2025517969 A2025-06-1212789Q13946Espacenet
JP 2025032204 A2025-03-1133179Q13946Espacenet
JP 2025028160 A2025-02-2810169Q13946Espacenet
KR 1020250017231 A2025-02-046076Q13946Espacenet

1 to 10 of 47

See all 47 patents

Drugs4

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
DIPYRIDAMOLECHEMBL9323',5'-cyclic phosphodiesterase inhibitorINHIBITORChEMBL
FLAVOXATECHEMBL1493Phosphodiesterase 7 inhibitorINHIBITORChEMBL
FLAVOXATE HYDROCHLORIDECHEMBL1200875Phosphodiesterase 7 inhibitorINHIBITORChEMBL
PENTOXIFYLLINECHEMBL6283',5'-cyclic phosphodiesterase inhibitorINHIBITORChEMBL

Trials135

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07349472PENTOXIFYLLINEPHASE2ClinicalTrials.gov
NCT07315139PENTOXIFYLLINEClinicalTrials.gov
NCT07252518PENTOXIFYLLINEClinicalTrials.gov
NCT07199504DIPYRIDAMOLEPHASE2/PHASE3ClinicalTrials.gov
NCT07088328PENTOXIFYLLINEClinicalTrials.gov
NCT07086794PENTOXIFYLLINEEARLY_PHASE1ClinicalTrials.gov
NCT07085806PENTOXIFYLLINEClinicalTrials.gov
NCT06998628PENTOXIFYLLINEPHASE2ClinicalTrials.gov
NCT06986031PENTOXIFYLLINEPHASE2ClinicalTrials.gov
NCT06912763PENTOXIFYLLINEPHASE2ClinicalTrials.gov

1 to 10 of 135

See all 135 trials

NIH grants423

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePDE7A papersNewest fiscal year
P30CA008748Cancer Center Support Grant52025
UL1TR001863Yale Clinical and Translational Science Award32025
P20GM113226Hepatobiology and Toxicology COBRE22025
P30DK116074Stanford Diabetes Research Center22025
P50AA024337The Role of Nutrition in the Development/Progression of Alcohol-Induced Organ Injury22025
R01DK080834Inhibition of an Apical cAMP/cGMP Transporter (MRP4) in the Gut Induces Diarrhea22025
I01CX001897Genetic of Kidney Disease and Hypertension in MVP II12025
K01AA030083Mass Multivariate Derivation and Validation of AUD Biotypes using Developmental Imaging and Genomic Approaches12025
P01CA022443Molecular Biology and Genetics of Human Tumor Viruses12025
P20GM113131Center of Integrated Biomedical and Bioengineering Research (CIBBR)12025

1 to 10 of 423Source NIH's project files

See all 423 nih grants

Papers669

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Both Conserved Aromatic Nature and Critical RNA Motif of Residue 67 in the ToBRFV Movement Protein May Be Essential for Evading Tm-22-Mediated Resistance.Mol Plant Pathol202642438102PubTator, text miningPubMed
Heterocyclic Scaffolds as Therapeutic Agents in Multiple Sclerosis: Mechanisms and SAR Study.Cent Nerv Syst Agents Med Chem202642393898PubTator, text miningPubMed
Tomato Brown Rugose Fruit Virus Evades Tm-22-Mediated Resistance by Avoiding the Induction of Tm-22 Self-Association.Mol Plant Pathol202641852156PubTator, text miningPubMed
Biological implications and therapeutic potential of phosphodiesterase inhibitors: A review.Medicine (Baltimore)202641790675PubTator, text miningPubMed
Single-Cell Transcriptomic Profile Associated with Sub-Subtype A6 and CRF63-02A6 HIV-1 Strain Infection.Viruses202641754547PubTator, text miningPubMed
Family-Wide Dysregulation of Phosphodiesterases Alters cAMP/cGMP Microdomains in Thoracic Aortic Aneurysm.J Cardiovasc Dev Dis202641590850PubTator, text miningPubMed
Integrative multi-omics analyses identify key genes and elucidate bidirectional regulatory mechanisms in thyroid dysfunction.PLoS One202641570039PubTator, text miningPubMed
Advanced molecular tools for surveillance and management of tobamoviruses.Front Plant Sci202541613398PubTator, text miningPubMed
Pan-Cancer Analysis of Cyclic Nucleotide Phosphodiesterases (PDEs) Expression, Variation, and Prognostic Significance.ACS Omega202541476499PubTator, text miningPubMed
Expanding disease resistance: engineered NLRS for broad-spectrum protection.Mol Hortic202541276870PubTator, text miningPubMed

1 to 10 of 669

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Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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