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Gene · 5151

PDE8A: phosphodiesterase 8A

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PDE8A: phosphodiesterase 8A. Genes, record 5151. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5151

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Gene

Symbol
PDE8A
HGNC
Name
phosphodiesterase 8A
HGNC
NCBI Gene ID
5151
NCBI Gene
HGNC ID
HGNC:8793
HGNC
Ensembl
ENSG00000073417
NCBI Gene
Aliases
HsT19550
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O60658High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A82910Ensembl, GeneID, HGNC

Source UniProt

Patents34

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1457766O60658Espacenet
JP 2026004568 A2026-01-1457768O60658Espacenet
EP 4650780 A22025-11-194759O60658Espacenet
JP 2025517970 A2025-06-124759O60658Espacenet
JP 2025032204 A2025-03-1133186O60658Espacenet
JP 2025032204 A2025-03-1133193O60658Espacenet
JP 2025004127 A2025-01-1418O60658Espacenet
EP 4461818 A22024-11-1333186O60658Espacenet
EP 4461818 A22024-11-1333193O60658Espacenet
EP 4374872 A12024-05-29110O60658Espacenet

1 to 10 of 34

See all 34 patents

Drugs4

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
DIPYRIDAMOLECHEMBL9323',5'-cyclic phosphodiesterase inhibitorINHIBITORChEMBL
FLAVOXATECHEMBL1493Phosphodiesterase 8 inhibitorINHIBITORChEMBL
FLAVOXATE HYDROCHLORIDECHEMBL1200875Phosphodiesterase 8 inhibitorINHIBITORChEMBL
PENTOXIFYLLINECHEMBL6283',5'-cyclic phosphodiesterase inhibitorINHIBITORChEMBL

Trials135

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07349472PENTOXIFYLLINEPHASE2ClinicalTrials.gov
NCT07315139PENTOXIFYLLINEClinicalTrials.gov
NCT07252518PENTOXIFYLLINEClinicalTrials.gov
NCT07199504DIPYRIDAMOLEPHASE2/PHASE3ClinicalTrials.gov
NCT07088328PENTOXIFYLLINEClinicalTrials.gov
NCT07086794PENTOXIFYLLINEEARLY_PHASE1ClinicalTrials.gov
NCT07085806PENTOXIFYLLINEClinicalTrials.gov
NCT06998628PENTOXIFYLLINEPHASE2ClinicalTrials.gov
NCT06986031PENTOXIFYLLINEPHASE2ClinicalTrials.gov
NCT06912763PENTOXIFYLLINEPHASE2ClinicalTrials.gov

1 to 10 of 135

See all 135 trials

NIH grants282

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePDE8A papersNewest fiscal year
R01HL131517Sex-specific arrhythmogenic mechanisms of atrial fibrillation22025
R01HL136389The Role of Gasdermin-D/Interleukin-1 Nexus in Atrial Arrhythmogenesis22025
K08AI163381Immunoproteomic mechanisms of human macrophage resistance to Mycobacterium tuberculosis infection12025
P20GM113226Hepatobiology and Toxicology COBRE12025
P30AI027757University of Washington/Fred Hutch Center for AIDS Research12025
P30AR075042Center for Musculoskeletal Research12025
P30CA008748Cancer Center Support Grant12025
P30CA014236Cancer Center Support Grant (CCSG)12025
P30CA016058Cancer Center Support Grant12025
P30CA016087Cancer Center Support Grant12025

1 to 10 of 282Source NIH's project files

See all 282 nih grants

Papers395

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Identification of key genes and mechanistic exploration of metabolic reprogramming in osteoporosis.J Int Med Res202642805907PubTator, text miningPubMed
Phosphodiesterase 8 (PDE8), a novel target for neurodegenerative diseases.Cell Signal202642251942PubTator, text miningPubMed
Regulation of cAMP levels in osteocytes by mechano-sensitive focal adhesion kinase and phosphodiesterase 8A.iScience202642231949PubTator, text miningPubMed
Therapeutic Effects of Phosphodiesterase Inhibitors on Hypertensive Disorders in Pregnancy and Fetal Growth Restriction: A Drug Targeted Mendelian Randomization Study.Curr Med Chem202642227534PubTator, text miningPubMed
Phosphodiesterase inhibitors as emerging therapeutics for skeletal disorders: A comprehensive review of mechanisms and repurposing potential.Bone Rep202641732176PubTator, text miningPubMed
Family-Wide Dysregulation of Phosphodiesterases Alters cAMP/cGMP Microdomains in Thoracic Aortic Aneurysm.J Cardiovasc Dev Dis202641590850PubTator, text miningPubMed
Integrative multi-omics analyses identify key genes and elucidate bidirectional regulatory mechanisms in thyroid dysfunction.PLoS One202641570039PubTator, text miningPubMed
Pan-Cancer Analysis of Cyclic Nucleotide Phosphodiesterases (PDEs) Expression, Variation, and Prognostic Significance.ACS Omega202541476499PubTator, text miningPubMed
Integrative Epigenomic and Targeted Protein Analysis in MRONJ: Correlating DNA Methylation with Bone Biomarkers.Int J Mol Sci202541303691PubTator, text miningPubMed
BCG induced innate immune response heterogeneity and susceptibility to pediatric tuberculosis.J Immunol202540174917PubTator, text miningPubMed

1 to 10 of 395

See all 395 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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