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Gene · 5153

PDE1B: phosphodiesterase 1B

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PDE1B: phosphodiesterase 1B. Genes, record 5153. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5153

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Gene

Symbol
PDE1B
HGNC
Name
phosphodiesterase 1B
HGNC
NCBI Gene ID
5153
NCBI Gene
HGNC ID
HGNC:8775
HGNC
Ensembl
ENSG00000123360
NCBI Gene
Aliases
HEL-S-79p, PDE1B1, PDES1B
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q01064Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B5367Ensembl, GeneID, HGNC

Source UniProt

Patents27

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1457696Q01064Espacenet
EP 4641201 A22025-10-29758Q01064Espacenet
JP 2025517969 A2025-06-12758Q01064Espacenet
JP 2025032204 A2025-03-1133142Q01064Espacenet
JP 2025004127 A2025-01-144Q01064Espacenet
EP 4461818 A22024-11-1333142Q01064Espacenet
EP 4374872 A12024-05-294Q01064Espacenet
JP 2023144094 A2023-10-06109Q01064Espacenet
US 11666642 B22023-06-06109Q01064Espacenet
JP 2023058610 A2023-04-2533142Q01064Espacenet

1 to 10 of 27

See all 27 patents

Drugs2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
DIPYRIDAMOLECHEMBL9323',5'-cyclic phosphodiesterase inhibitorINHIBITORChEMBL
PENTOXIFYLLINECHEMBL6283',5'-cyclic phosphodiesterase inhibitorINHIBITORChEMBL

Trials135

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07349472PENTOXIFYLLINEPHASE2ClinicalTrials.gov
NCT07315139PENTOXIFYLLINEClinicalTrials.gov
NCT07252518PENTOXIFYLLINEClinicalTrials.gov
NCT07199504DIPYRIDAMOLEPHASE2/PHASE3ClinicalTrials.gov
NCT07088328PENTOXIFYLLINEClinicalTrials.gov
NCT07086794PENTOXIFYLLINEEARLY_PHASE1ClinicalTrials.gov
NCT07085806PENTOXIFYLLINEClinicalTrials.gov
NCT06998628PENTOXIFYLLINEPHASE2ClinicalTrials.gov
NCT06986031PENTOXIFYLLINEPHASE2ClinicalTrials.gov
NCT06912763PENTOXIFYLLINEPHASE2ClinicalTrials.gov

1 to 10 of 135

See all 135 trials

NIH grants286

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePDE1B papersNewest fiscal year
T32HL007227Pathophysiology of Myocardial Disease42025
P30CA008748Cancer Center Support Grant22025
P30CA043703Case Comprehensive Cancer Center Support Grant22025
D43TW009114Psychiatric research infrastructure for intervention and implementation in India – TEAMS12025
P01DA047233Transcriptional Mechanisms of Drug Addiction12025
P20GM113131Center of Integrated Biomedical and Bioengineering Research (CIBBR)12025
P30AG072975Rush Alzheimer's Disease Research Center12025
P30CA013148Comprehensive Cancer Center Support Grant12025
P30CA016672Cancer Center Support Grant12025
P30CA042014Cancer Center Support Grant12025

1 to 10 of 286Source NIH's project files

See all 286 nih grants

Papers354

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Pde1b controls cyclic nucleotide signaling in cDC1 and macrophages to regulate immune responses.EMBO Rep202642744925PubTator, text miningPubMed
Crucial role of telomere maintenance-related genes in survival prediction and subtype identification in colorectal cancer.Front Mol Biosci202642729150PubTator, text miningPubMed
Genomic Evidence for Natural Selection Underlying High-Altitude Adaptive Hemoglobin Levels Among Peruvian Andeans.Genome Biol Evol202642402195PubTator, text miningPubMed
Improving pancreatic adenocarcinoma prognosis models through ligand receptor interactions and histopathological integration.J Transl Med202642399741PubTator, text miningPubMed
The aging epigenome: integrative analyses reveal intersection with Alzheimer's disease.Geroscience202641975027PubTator, text miningPubMed
No New Relevant Treatment Options for L-DOPA-Induced Dyskinesia from a Clinician's Point of View.Neurol Int202641893061PubTator, text miningPubMed
Molecular Mechanisms and Clinical Applications of Buyang Huanwu Decoction in the Treatment of Ischemic Stroke: A Review.Int J Gen Med202641810314PubTator, text miningPubMed
Biological implications and therapeutic potential of phosphodiesterase inhibitors: A review.Medicine (Baltimore)202641790675PubTator, text miningPubMed
Phosphodiesterase inhibitors as emerging therapeutics for skeletal disorders: A comprehensive review of mechanisms and repurposing potential.Bone Rep202641732176PubTator, text miningPubMed
Associations of air pollution and genetic risk and their interaction with risk of Alzheimer's disease: identification of risk loci and potential biological pathways.Geroscience202641571964PubTator, text miningPubMed

1 to 10 of 354

See all 354 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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