Gene · 5153
PDE1B: phosphodiesterase 1B
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. PDE1B: phosphodiesterase 1B. Genes, record 5153. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5153
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q01064 | Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B | 536 | 7 | Ensembl, GeneID, HGNC |
Source UniProt
Patents27
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 57696 | Q01064 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 758 | Q01064 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 758 | Q01064 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 33142 | Q01064 | Espacenet |
| JP 2025004127 A | 2025-01-14 | 4 | Q01064 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 33142 | Q01064 | Espacenet |
| EP 4374872 A1 | 2024-05-29 | 4 | Q01064 | Espacenet |
| JP 2023144094 A | 2023-10-06 | 109 | Q01064 | Espacenet |
| US 11666642 B2 | 2023-06-06 | 109 | Q01064 | Espacenet |
| JP 2023058610 A | 2023-04-25 | 33142 | Q01064 | Espacenet |
1 to 10 of 27
See all 27 patentsDrugs2
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
Trials135
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07349472 | PENTOXIFYLLINE | PHASE2 | ClinicalTrials.gov | |
| NCT07315139 | PENTOXIFYLLINE | ClinicalTrials.gov | ||
| NCT07252518 | PENTOXIFYLLINE | ClinicalTrials.gov | ||
| NCT07199504 | DIPYRIDAMOLE | PHASE2/PHASE3 | ClinicalTrials.gov | |
| NCT07088328 | PENTOXIFYLLINE | ClinicalTrials.gov | ||
| NCT07086794 | PENTOXIFYLLINE | EARLY_PHASE1 | ClinicalTrials.gov | |
| NCT07085806 | PENTOXIFYLLINE | ClinicalTrials.gov | ||
| NCT06998628 | PENTOXIFYLLINE | PHASE2 | ClinicalTrials.gov | |
| NCT06986031 | PENTOXIFYLLINE | PHASE2 | ClinicalTrials.gov | |
| NCT06912763 | PENTOXIFYLLINE | PHASE2 | ClinicalTrials.gov |
1 to 10 of 135
See all 135 trialsNIH grants286
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | PDE1B papers | Newest fiscal year |
|---|---|---|---|
| T32HL007227 | Pathophysiology of Myocardial Disease | 4 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 2 | 2025 |
| P30CA043703 | Case Comprehensive Cancer Center Support Grant | 2 | 2025 |
| D43TW009114 | Psychiatric research infrastructure for intervention and implementation in India – TEAMS | 1 | 2025 |
| P01DA047233 | Transcriptional Mechanisms of Drug Addiction | 1 | 2025 |
| P20GM113131 | Center of Integrated Biomedical and Bioengineering Research (CIBBR) | 1 | 2025 |
| P30AG072975 | Rush Alzheimer's Disease Research Center | 1 | 2025 |
| P30CA013148 | Comprehensive Cancer Center Support Grant | 1 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 1 | 2025 |
| P30CA042014 | Cancer Center Support Grant | 1 | 2025 |
1 to 10 of 286Source NIH's project files
See all 286 nih grantsPapers354
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Pde1b controls cyclic nucleotide signaling in cDC1 and macrophages to regulate immune responses. | EMBO Rep | 2026 | 42744925 | PubTator, text mining | PubMed |
| Crucial role of telomere maintenance-related genes in survival prediction and subtype identification in colorectal cancer. | Front Mol Biosci | 2026 | 42729150 | PubTator, text mining | PubMed |
| Genomic Evidence for Natural Selection Underlying High-Altitude Adaptive Hemoglobin Levels Among Peruvian Andeans. | Genome Biol Evol | 2026 | 42402195 | PubTator, text mining | PubMed |
| Improving pancreatic adenocarcinoma prognosis models through ligand receptor interactions and histopathological integration. | J Transl Med | 2026 | 42399741 | PubTator, text mining | PubMed |
| The aging epigenome: integrative analyses reveal intersection with Alzheimer's disease. | Geroscience | 2026 | 41975027 | PubTator, text mining | PubMed |
| No New Relevant Treatment Options for L-DOPA-Induced Dyskinesia from a Clinician's Point of View. | Neurol Int | 2026 | 41893061 | PubTator, text mining | PubMed |
| Molecular Mechanisms and Clinical Applications of Buyang Huanwu Decoction in the Treatment of Ischemic Stroke: A Review. | Int J Gen Med | 2026 | 41810314 | PubTator, text mining | PubMed |
| Biological implications and therapeutic potential of phosphodiesterase inhibitors: A review. | Medicine (Baltimore) | 2026 | 41790675 | PubTator, text mining | PubMed |
| Phosphodiesterase inhibitors as emerging therapeutics for skeletal disorders: A comprehensive review of mechanisms and repurposing potential. | Bone Rep | 2026 | 41732176 | PubTator, text mining | PubMed |
| Associations of air pollution and genetic risk and their interaction with risk of Alzheimer's disease: identification of risk loci and potential biological pathways. | Geroscience | 2026 | 41571964 | PubTator, text mining | PubMed |
1 to 10 of 354
See all 354 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/5153
GET https://conductscience.org/api/genes/v1/5153/patents?page=2