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Gene · 5158

PDE6B: phosphodiesterase 6B

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PDE6B: phosphodiesterase 6B. Genes, record 5158. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5158

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Gene

Symbol
PDE6B
HGNC
Name
phosphodiesterase 6B
HGNC
NCBI Gene ID
5158
NCBI Gene
HGNC ID
HGNC:8786
HGNC
Ensembl
ENSG00000133256
NCBI Gene
Aliases
CSNB3, CSNBAD2, GMP-PDEbeta, PDEB, RP40, rd1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P35913Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta8540Ensembl, GeneID, HGNC

Source UniProt

Patents23

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026515744 A2026-05-1990P35913Espacenet
JP 2026004568 A2026-01-1457757P35913Espacenet
EP 4641201 A22025-10-2916894P35913Espacenet
JP 2025517969 A2025-06-1216894P35913Espacenet
US 12246072 B22025-03-1127P35913Espacenet
JP 2025004127 A2025-01-1414P35913Espacenet
WO 2024214081 A12024-10-1790P35913Espacenet
JP 2024105661 A2024-08-0660P35913Espacenet
EP 4374872 A12024-05-2996P35913Espacenet
JP 2023144094 A2023-10-06129P35913Espacenet

1 to 10 of 23

See all 23 patents

Drugs2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
DIPYRIDAMOLECHEMBL9323',5'-cyclic phosphodiesterase inhibitorINHIBITORChEMBL
PENTOXIFYLLINECHEMBL6283',5'-cyclic phosphodiesterase inhibitorINHIBITORChEMBL

Trials135

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07349472PENTOXIFYLLINEPHASE2ClinicalTrials.gov
NCT07315139PENTOXIFYLLINEClinicalTrials.gov
NCT07252518PENTOXIFYLLINEClinicalTrials.gov
NCT07199504DIPYRIDAMOLEPHASE2/PHASE3ClinicalTrials.gov
NCT07088328PENTOXIFYLLINEClinicalTrials.gov
NCT07086794PENTOXIFYLLINEEARLY_PHASE1ClinicalTrials.gov
NCT07085806PENTOXIFYLLINEClinicalTrials.gov
NCT06998628PENTOXIFYLLINEPHASE2ClinicalTrials.gov
NCT06986031PENTOXIFYLLINEPHASE2ClinicalTrials.gov
NCT06912763PENTOXIFYLLINEPHASE2ClinicalTrials.gov

1 to 10 of 135

See all 135 trials

NIH grants909

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePDE6B papersNewest fiscal year
R01EY018213Defining Barriers to Gene Therapy232025
R01EY006855Models for Therapy of Hereditary Retinal Degeneration142025
P30CA013696Cancer Center Support Grant122025
P30EY000331Vision Research Core at UCLA92025
P30EY001583P30 Core Grant For Vision Research92025
P30EY022589NEI Center Core Grant for Vision Research92025
R01EY010843Regulation of Retinal cGMP-Phosphodiesterases92025
R01EY024698Gene Editing and Silencing in Phototransduction92025
P30EY014104P30 Core Grant for Vision Research82025
R01EY022356Molecular Basis of Human Visual System Disorders62025

1 to 10 of 909Source NIH's project files

See all 909 nih grants

Papers1,506

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Novel insights of minocycline as a neurovascular protective agent in retinitis pigmentosa.Br J Ophthalmol202642665364PubTator, text miningPubMed
Injectable Artificial Photoreceptors: STEM Cell Functional Integration and in vivo Electrophysiological Validation in Retinal Degeneration Models.Small Sci202642549431PubTator, text miningPubMed
Shigella's c-di-GMP specific PDEs Modulate Biofilm and Virulence Phenotypes.bioRxiv202642395518PubTator, text miningPubMed
Streamlined synthetic regulatory cassette for efficient and photoreceptor-enriched retinal gene expression.Mol Ther Nucleic Acids202642367246PubTator, text miningPubMed
Insights into ANKRD11-related epilepsy from 163 people.Epilepsia202642322264PubTator, text miningPubMed
Expanding the Mutation Spectrum of Non-Syndromic Retinitis Pigmentosa in Consanguineous Pakistani Families: Unraveling Novel Pathogenic Variants in RP1, PDE6B, and PRCD Genes for Precision Diagnosis.Genes (Basel)202642194986PubTator, text miningPubMed
Synergistic antioxidant and gene supplementation for high-efficacy retinitis pigmentosa therapy.Sci Adv202642127191PubTator, text miningPubMed
Enhancing detection efficiency of RD-proteins in Mycobacterium tuberculosis culture filtrate by biomimetic affinity chromatography coupled with LC-MS/MS.J Chromatogr B Analyt Technol Biomed Life Sci202642048679PubTator, text miningPubMed
A highly dynamic active state for transducin-bound phosphodiesterase-6 in vertebrate phototransduction.bioRxiv202641959389PubTator, text miningPubMed
How Does Genetic Information Enable Life?Bull Math Biol202641936728PubTator, text miningPubMed

1 to 10 of 1,506

See all 1,506 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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