Gene · 5168
ENPP2: ectonucleotide pyrophosphatase/phosphodiesterase 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. ENPP2: ectonucleotide pyrophosphatase/phosphodiesterase 2. Genes, record 5168. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5168
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q13822 | Autotaxin | 863 | 9 | Ensembl, GeneID, HGNC |
Source UniProt
Patents29
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| WO 2026209893 A1 | 2026-10-08 | 1 | Q13822 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 44721 | Q13822 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 100 | Q13822 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 74 | Q13822 | Espacenet |
| EP 4641202 A2 | 2025-10-29 | 4286 | Q13822 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 1396 | Q13822 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 1396 | Q13822 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 74 | Q13822 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 100 | Q13822 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 27833 | Q13822 | Espacenet |
1 to 10 of 29
See all 29 patentsDrugs1
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action |
|---|---|---|---|
| ZIRITAXESTAT | CHEMBL3828074 | Autotaxin inhibitor | INHIBITOR |
Source ChEMBL
Trials5
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT03976648 | ZIRITAXESTAT | PHASE2 | 2022-03-15 | ClinicalTrials.gov |
| NCT03798366 | ZIRITAXESTAT | PHASE2 | 2021-05-04 | ClinicalTrials.gov |
| NCT03733444 | ZIRITAXESTAT | PHASE3 | 2022-07-29 | ClinicalTrials.gov |
| NCT03711162 | ZIRITAXESTAT | PHASE3 | 2022-07-29 | ClinicalTrials.gov |
| NCT02738801 | ZIRITAXESTAT | PHASE2 | 2020-11-06 | ClinicalTrials.gov |
NIH grants1,838
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | ENPP2 papers | Newest fiscal year |
|---|---|---|---|
| P30CA016672 | Cancer Center Support Grant | 19 | 2025 |
| P30EY005722 | Center Core Grant for Vision Research | 6 | 2025 |
| I01BX001894 | Role of NK cells in control of HCV infection associated hepatocellular carcinoma | 5 | 2025 |
| P30CA016059 | Massey Cancer Center - Cancer Center Support Grant | 5 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 5 | 2025 |
| P30ES001247 | Environmental Agents as Modulators of Disease Processes | 5 | 2025 |
| P30EY014801 | Miami Center for Vision Research | 5 | 2025 |
| P30CA016087 | Cancer Center Support Grant | 4 | 2025 |
| D43TW010319 | Microbiology and Immunology Training for HIV and HIV-Related Research in Uganda (MITHU) | 3 | 2025 |
| P01CA117969 | Genetics and Biology of Pancreatic Ductal Adenocarcinoma | 3 | 2025 |
1 to 10 of 1,838Source NIH's project files
See all 1,838 nih grantsPapers3,090
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| A rare ATM variant in a Colombian family with chorea-ataxia syndrome: implications for an early diagnosis. | Neurogenetics | 2026 | 42782344 | PubTator, text mining | PubMed |
| Autotaxin as a potential biomarker in hepatic encephalopathy: Insights from a mouse model and cirrhotic patients. | Cell Mol Biol (Noisy-le-grand) | 2026 | 42758110 | PubTator, text mining | PubMed |
| Identification of New Putative Autotaxin Inhibitors via Structure-Based Virtual Screening and Evaluation of Their Antiproliferative Properties Against Ovarian and Breast Cancer Cells. | ChemMedChem | 2026 | 42675576 | PubTator, text mining | PubMed |
| Development of potent and selective ENPP1 inhibitors based on imidazo[1,2-a]pyrazine and pyrazine scaffolds for cancer immunotherapy. | Eur J Med Chem | 2026 | 42648057 | PubTator, text mining | PubMed |
| Lipoprotein(a) and calcific aortic stenosis: from inherited risk marker to therapeutic target. | Front Med (Lausanne) | 2026 | 42620888 | PubTator, text mining | PubMed |
| Role of Lipoprotein(a) in Aortic Valve Calcification: Inflammatory and Oxidative Mechanisms Involved. | Int J Mol Sci | 2026 | 42589297 | PubTator, text mining | PubMed |
| Biology and function of the autotaxin/lysophosphatidic acid axis in cancer (Review). | Mol Clin Oncol | 2026 | 42577702 | PubTator, text mining | PubMed |
| Expanded ATXN10 Alleles in Neurodegenerative Disorders: A Case Series and Review of the Literature. | Mov Disord Clin Pract | 2026 | 42569794 | PubTator, text mining | PubMed |
| Lysophosphatidylcholine and lysophosphatidic acid as key messengers in atherosclerosis: from a lipid-inflammation vicious cycle to therapeutic translation. | Front Cardiovasc Med | 2026 | 42553033 | PubTator, text mining | PubMed |
| Characterizing the impact of plasma protein levels on human brain structure and disorders leveraging integrative multi-omics analysis. | medRxiv | 2026 | 42528609 | PubTator, text mining | PubMed |
1 to 10 of 3,090
See all 3,090 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/5168
GET https://conductscience.org/api/genes/v1/5168/patents?page=2