ConductScience.org, home

Gene · 5168

ENPP2: ectonucleotide pyrophosphatase/phosphodiesterase 2

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. ENPP2: ectonucleotide pyrophosphatase/phosphodiesterase 2. Genes, record 5168. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5168

On this page

Gene

Symbol
ENPP2
HGNC
Name
ectonucleotide pyrophosphatase/phosphodiesterase 2
HGNC
NCBI Gene ID
5168
NCBI Gene
HGNC ID
HGNC:3357
HGNC
Ensembl
ENSG00000136960
NCBI Gene
Aliases
ATX, ATX-X, AUTOTAXIN, LysoPLD, NPP2, PD-IALPHA, PDNP2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q13822Autotaxin8639Ensembl, GeneID, HGNC

Source UniProt

Patents29

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
WO 2026209893 A12026-10-081Q13822Espacenet
JP 2026004568 A2026-01-1444721Q13822Espacenet
EP 4650780 A22025-11-19100Q13822Espacenet
EP 4641201 A22025-10-2974Q13822Espacenet
EP 4641202 A22025-10-294286Q13822Espacenet
JP 2025529142 A2025-09-041396Q13822Espacenet
US 12371689 B22025-07-291396Q13822Espacenet
JP 2025517969 A2025-06-1274Q13822Espacenet
JP 2025517970 A2025-06-12100Q13822Espacenet
JP 2025032204 A2025-03-1127833Q13822Espacenet

1 to 10 of 29

See all 29 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
ZIRITAXESTATCHEMBL3828074Autotaxin inhibitorINHIBITOR

Source ChEMBL

Trials5

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT03976648ZIRITAXESTATPHASE22022-03-15ClinicalTrials.gov
NCT03798366ZIRITAXESTATPHASE22021-05-04ClinicalTrials.gov
NCT03733444ZIRITAXESTATPHASE32022-07-29ClinicalTrials.gov
NCT03711162ZIRITAXESTATPHASE32022-07-29ClinicalTrials.gov
NCT02738801ZIRITAXESTATPHASE22020-11-06ClinicalTrials.gov

NIH grants1,838

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleENPP2 papersNewest fiscal year
P30CA016672Cancer Center Support Grant192025
P30EY005722Center Core Grant for Vision Research62025
I01BX001894Role of NK cells in control of HCV infection associated hepatocellular carcinoma52025
P30CA016059Massey Cancer Center - Cancer Center Support Grant52025
P30CA068485Cancer Center Support Grant52025
P30ES001247Environmental Agents as Modulators of Disease Processes52025
P30EY014801Miami Center for Vision Research52025
P30CA016087Cancer Center Support Grant42025
D43TW010319Microbiology and Immunology Training for HIV and HIV-Related Research in Uganda (MITHU)32025
P01CA117969Genetics and Biology of Pancreatic Ductal Adenocarcinoma32025

1 to 10 of 1,838Source NIH's project files

See all 1,838 nih grants

Papers3,090

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
A rare ATM variant in a Colombian family with chorea-ataxia syndrome: implications for an early diagnosis.Neurogenetics202642782344PubTator, text miningPubMed
Autotaxin as a potential biomarker in hepatic encephalopathy: Insights from a mouse model and cirrhotic patients.Cell Mol Biol (Noisy-le-grand)202642758110PubTator, text miningPubMed
Identification of New Putative Autotaxin Inhibitors via Structure-Based Virtual Screening and Evaluation of Their Antiproliferative Properties Against Ovarian and Breast Cancer Cells.ChemMedChem202642675576PubTator, text miningPubMed
Development of potent and selective ENPP1 inhibitors based on imidazo[1,2-a]pyrazine and pyrazine scaffolds for cancer immunotherapy.Eur J Med Chem202642648057PubTator, text miningPubMed
Lipoprotein(a) and calcific aortic stenosis: from inherited risk marker to therapeutic target.Front Med (Lausanne)202642620888PubTator, text miningPubMed
Role of Lipoprotein(a) in Aortic Valve Calcification: Inflammatory and Oxidative Mechanisms Involved.Int J Mol Sci202642589297PubTator, text miningPubMed
Biology and function of the autotaxin/lysophosphatidic acid axis in cancer (Review).Mol Clin Oncol202642577702PubTator, text miningPubMed
Expanded ATXN10 Alleles in Neurodegenerative Disorders: A Case Series and Review of the Literature.Mov Disord Clin Pract202642569794PubTator, text miningPubMed
Lysophosphatidylcholine and lysophosphatidic acid as key messengers in atherosclerosis: from a lipid-inflammation vicious cycle to therapeutic translation.Front Cardiovasc Med202642553033PubTator, text miningPubMed
Characterizing the impact of plasma protein levels on human brain structure and disorders leveraging integrative multi-omics analysis.medRxiv202642528609PubTator, text miningPubMed

1 to 10 of 3,090

See all 3,090 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5168

GET https://conductscience.org/api/genes/v1/5168/patents?page=2