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Gene · 5313

PKLR: pyruvate kinase L/R

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PKLR: pyruvate kinase L/R. Genes, record 5313. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5313

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Gene

Symbol
PKLR
HGNC
Name
pyruvate kinase L/R
HGNC
NCBI Gene ID
5313
NCBI Gene
HGNC ID
HGNC:9020
HGNC
Ensembl
ENSG00000143627
NCBI Gene
Aliases
CNSHA2, PK1, PKL, PKRL, RPK
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P30613Pyruvate kinase PKLR57458Ensembl, GeneID, HGNC

Source UniProt

Patents29

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026067851 A2026-04-21401P30613Espacenet
JP 2026004568 A2026-01-1460585P30613Espacenet
EP 4640849 A22025-10-29925P30613Espacenet
EP 4641201 A22025-10-296237P30613Espacenet
JP 2025519096 A2025-06-24925P30613Espacenet
JP 2025517969 A2025-06-126237P30613Espacenet
JP 2025038075 A2025-03-186P30613Espacenet
JP 2023521663 A2023-05-25400P30613Espacenet
US 11446398 B22022-09-2070366P30613Espacenet
US 11446398 B22022-09-2070370P30613Espacenet

1 to 10 of 29

See all 29 patents

Drugs3

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ETAVOPIVATCHEMBL4650332Pyruvate kinase isozymes R/L activatorACTIVATORChEMBL
MITAPIVATCHEMBL4299940Pyruvate kinase isozymes R/L activatorACTIVATORChEMBL
MITAPIVAT SULFATECHEMBL4297223Pyruvate kinase isozymes R/L activatorACTIVATORChEMBL

Trials26

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07517133MITAPIVATPHASE3ClinicalTrials.gov
NCT07506863MITAPIVATPHASE3ClinicalTrials.gov
NCT07055243MITAPIVATPHASE2ClinicalTrials.gov
NCT06612268ETAVOPIVATPHASE3ClinicalTrials.gov
NCT06609226ETAVOPIVATPHASE3ClinicalTrials.gov
NCT06286046MITAPIVATPHASE2ClinicalTrials.gov
NCT06198712ETAVOPIVATPHASE2ClinicalTrials.gov
NCT05953584ETAVOPIVATPHASE2ClinicalTrials.gov
NCT05935202MITAPIVAT SULFATEPHASE2ClinicalTrials.gov
NCT05725902ETAVOPIVATPHASE2ClinicalTrials.gov

1 to 10 of 26

See all 26 trials

NIH grants1,543

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePKLR papersNewest fiscal year
P30CA016672Cancer Center Support Grant82025
P30CA008748Cancer Center Support Grant62025
R01DK103794Systematic Genetic Dissection of Human Erythropoiesis52025
T32DK007665Metabolism and Nutrition Training Program52025
P30AI094189The Johns Hopkins Center for AIDS Research (JHU CFAR)42025
P30CA046934University of Colorado Cancer Center Support Grant42025
P30DK045735Yale Diabetes Research Center42025
R01AI133348Mechanisms of viral RNA maturation by co-opting cellular exonucleases42025
R35CA242379Understanding the role of metabolism in cancer42025
R35GM131795Systems-to-structure approaches for defining mitochondrial protein function42025

1 to 10 of 1,543Source NIH's project files

See all 1,543 nih grants

Papers2,223

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Interferon-stimulated restriction factors in enterovirus infection: A review on the mechanisms and antiviral roles of shiftless (C19orf66).Virology202742784970PubTator, text miningPubMed
Case Report: Successful hematopoietic stem cell transplantation in pediatric pyruvate kinase deficiency: a single-center Asian case series demonstrating favorable outcomes.Front Immunol202642707213PubTator, text miningPubMed
Systemic removal of host restriction factors enables rapid, scalable virus production for cell culture-based vaccine development.Front Bioeng Biotechnol202642698639PubTator, text miningPubMed
Severe Transfusion-Dependent Infantile Hemolytic Anemia Associated With a Novel Homozygous PKLR Variant of Uncertain Significance (c.1376C>G, p.Ala459Gly) and Coexisting G6PD Deficiency: A Case Report.
Cureus202642666890PubTator, text miningPubMed
Therapeutic and Predicted Significance of PKLR in Patients With Cholangiocarcinoma.Cancer Rep (Hoboken)202642599115PubTator, text miningPubMed
Post-Treatment Persistent Erythrocytosis in Patients with Hodgkin Lymphoma: Molecular Mechanisms Underlying the Pathogenesis of Erythrocytosis.Cancers (Basel)202642588719PubTator, text miningPubMed
From structural insight to molecule: Integrative molecular simulations identify candidate pyruvate kinase activators.PLoS One202642585268PubTator, text miningPubMed
Circadian Regulation of Glucose Metabolism: Implications for Pathogenesis and Chronotherapy of Type 2 Diabetes.Diabetology (Basel)202642583078PubTator, text miningPubMed
PKR engages viral RNA and intron-retained host transcripts during poxvirus infection.Cell Rep202642570237PubTator, text miningPubMed
Case Report: A research on a case of hereditary spherocytosis with idiopathic pulmonary hemosiderosis.Front Pediatr202642558654PubTator, text miningPubMed

1 to 10 of 2,223

See all 2,223 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5313

GET https://conductscience.org/api/genes/v1/5313/patents?page=2