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Gene · 54210

TREM1: triggering receptor expressed on myeloid cells 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. TREM1: triggering receptor expressed on myeloid cells 1. Genes, record 54210. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/54210

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Gene

Symbol
TREM1
HGNC
Name
triggering receptor expressed on myeloid cells 1
HGNC
NCBI Gene ID
54210
NCBI Gene
HGNC ID
HGNC:17760
HGNC
Ensembl
ENSG00000124731
NCBI Gene
Aliases
CD354, TREM-1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9NP99Triggering receptor expressed on myeloid cells 12342Ensembl, GeneID, HGNC

Source UniProt

Patents201

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026081251 A2026-05-181Q9NP99Espacenet
JP 2026514609 A2026-05-131Q9NP99Espacenet
JP 2026004568 A2026-01-1467947Q9NP99Espacenet
EP 4650780 A22025-11-191133Q9NP99Espacenet
EP 4641201 A22025-10-29804Q9NP99Espacenet
EP 4633648 A12025-10-2265Q9NP99Espacenet
JP 2025147176 A2025-10-0613739Q9NP99Espacenet
WO 2025196177 A12025-09-251Q9NP99Espacenet
WO 2025199118 A12025-09-25171Q9NP99Espacenet
EP 4617286 A22025-09-174Q9NP99Espacenet

1 to 10 of 201

See all 201 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
NANGIBOTIDECHEMBL4297793Triggering receptor expressed on myeloid cells 1 inhibitorINHIBITOR

Source ChEMBL

Trials3

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT04429334NANGIBOTIDEPHASE2ClinicalTrials.gov
NCT04055909NANGIBOTIDEPHASE2ClinicalTrials.gov
NCT03158948NANGIBOTIDEPHASE22024-10-08ClinicalTrials.gov

NIH grants1,803

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTREM1 papersNewest fiscal year
R35GM118337Novel Approaches to Maintaining Organ Function in Sepsis102025
P30CA016672Cancer Center Support Grant82025
R01HL076179Improvement of Organ Function after Severe Hypovolemia82025
UL1TR001863Yale Clinical and Translational Science Award72025
I01BX001786PGC-1 alpha in Lung Immune Response62025
P51OD011104Tulane National Primate Research Center62025
UM1AI068616SDMC - IMPAACT Leadership Group62025
P30AG028740University of Florida Older Americans Independence Center (OAIC)42025
P30CA062203Cancer Center Support Grant42025
P30CA076292Moffitt Cancer Center Support Grant42025

1 to 10 of 1,803Source NIH's project files

See all 1,803 nih grants

Papers3,294

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Evaluation of serum soluble triggering receptor expressed on myeloid cells-1 in polycystic ovary syndrome.Rev Assoc Med Bras (1992)202642820575PubTator, text miningPubMed
AI-Designed TREM1-Targeted LYTAC Nanoparticles Reprogram the Neuroimmune Microenvironment in Traumatic Brain Injury.Adv Sci (Weinh)202642801645PubTator, text miningPubMed
ACAT1-Mediated SP1-K694 Lactylation Promotes M1 Macrophage Polarization via TREM1 Transcription in COPD.Adv Sci (Weinh)202642801550PubTator, text miningPubMed
Treatment-Driven Peripheral Blood Transcriptomic Remodeling and Baseline Predictors of ESSDAI and STAR Response to B Cell Therapy in Sjögren's Disease.Arthritis Rheumatol202642781881PubTator, text miningPubMed
Host immune biomarkers associated with infection risk after CAR T-cell therapy.J Infect202642777835PubTator, text miningPubMed
Artificial intelligence-enabled cross-scale integration of traditional Chinese medicine and biomedicine for sepsis: from mechanisms to delivery.Front Pharmacol202642774781PubTator, text miningPubMed
Triggering receptors expressed on myeloid cells (TREM-1) and TREM-2 as predictors of pathological complete response to neoadjuvant therapy in triple-negative breast cancer.Breast Cancer202642766275PubTator, text miningPubMed
Exosomes target liver TREM-1 to break the systemic inflammatory cascade and improve spinal cord injury outcomes.J Orthop Translat202642761472PubTator, text miningPubMed
Circulating sTLR4 and sTREM-1 in Knee Osteoarthritis: Associations with Study-Specific MRI-Defined Categories and Disease Burden.J Clin Med202642739905PubTator, text miningPubMed
An analysis of cerebral amyloid angiopathy based on samples from human brain bank.Front Immunol202642682443PubTator, text miningPubMed

1 to 10 of 3,294

See all 3,294 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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