Gene · 54210
TREM1: triggering receptor expressed on myeloid cells 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. TREM1: triggering receptor expressed on myeloid cells 1. Genes, record 54210. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/54210
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q9NP99 | Triggering receptor expressed on myeloid cells 1 | 234 | 2 | Ensembl, GeneID, HGNC |
Source UniProt
Patents201
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026081251 A | 2026-05-18 | 1 | Q9NP99 | Espacenet |
| JP 2026514609 A | 2026-05-13 | 1 | Q9NP99 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 67947 | Q9NP99 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 1133 | Q9NP99 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 804 | Q9NP99 | Espacenet |
| EP 4633648 A1 | 2025-10-22 | 65 | Q9NP99 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 13739 | Q9NP99 | Espacenet |
| WO 2025196177 A1 | 2025-09-25 | 1 | Q9NP99 | Espacenet |
| WO 2025199118 A1 | 2025-09-25 | 171 | Q9NP99 | Espacenet |
| EP 4617286 A2 | 2025-09-17 | 4 | Q9NP99 | Espacenet |
1 to 10 of 201
See all 201 patentsDrugs1
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action |
|---|---|---|---|
| NANGIBOTIDE | CHEMBL4297793 | Triggering receptor expressed on myeloid cells 1 inhibitor | INHIBITOR |
Source ChEMBL
Trials3
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT04429334 | NANGIBOTIDE | PHASE2 | ClinicalTrials.gov | |
| NCT04055909 | NANGIBOTIDE | PHASE2 | ClinicalTrials.gov | |
| NCT03158948 | NANGIBOTIDE | PHASE2 | 2024-10-08 | ClinicalTrials.gov |
NIH grants1,803
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | TREM1 papers | Newest fiscal year |
|---|---|---|---|
| R35GM118337 | Novel Approaches to Maintaining Organ Function in Sepsis | 10 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 8 | 2025 |
| R01HL076179 | Improvement of Organ Function after Severe Hypovolemia | 8 | 2025 |
| UL1TR001863 | Yale Clinical and Translational Science Award | 7 | 2025 |
| I01BX001786 | PGC-1 alpha in Lung Immune Response | 6 | 2025 |
| P51OD011104 | Tulane National Primate Research Center | 6 | 2025 |
| UM1AI068616 | SDMC - IMPAACT Leadership Group | 6 | 2025 |
| P30AG028740 | University of Florida Older Americans Independence Center (OAIC) | 4 | 2025 |
| P30CA062203 | Cancer Center Support Grant | 4 | 2025 |
| P30CA076292 | Moffitt Cancer Center Support Grant | 4 | 2025 |
1 to 10 of 1,803Source NIH's project files
See all 1,803 nih grantsPapers3,294
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Evaluation of serum soluble triggering receptor expressed on myeloid cells-1 in polycystic ovary syndrome. | Rev Assoc Med Bras (1992) | 2026 | 42820575 | PubTator, text mining | PubMed |
| AI-Designed TREM1-Targeted LYTAC Nanoparticles Reprogram the Neuroimmune Microenvironment in Traumatic Brain Injury. | Adv Sci (Weinh) | 2026 | 42801645 | PubTator, text mining | PubMed |
| ACAT1-Mediated SP1-K694 Lactylation Promotes M1 Macrophage Polarization via TREM1 Transcription in COPD. | Adv Sci (Weinh) | 2026 | 42801550 | PubTator, text mining | PubMed |
| Treatment-Driven Peripheral Blood Transcriptomic Remodeling and Baseline Predictors of ESSDAI and STAR Response to B Cell Therapy in Sjögren's Disease. | Arthritis Rheumatol | 2026 | 42781881 | PubTator, text mining | PubMed |
| Host immune biomarkers associated with infection risk after CAR T-cell therapy. | J Infect | 2026 | 42777835 | PubTator, text mining | PubMed |
| Artificial intelligence-enabled cross-scale integration of traditional Chinese medicine and biomedicine for sepsis: from mechanisms to delivery. | Front Pharmacol | 2026 | 42774781 | PubTator, text mining | PubMed |
| Triggering receptors expressed on myeloid cells (TREM-1) and TREM-2 as predictors of pathological complete response to neoadjuvant therapy in triple-negative breast cancer. | Breast Cancer | 2026 | 42766275 | PubTator, text mining | PubMed |
| Exosomes target liver TREM-1 to break the systemic inflammatory cascade and improve spinal cord injury outcomes. | J Orthop Translat | 2026 | 42761472 | PubTator, text mining | PubMed |
| Circulating sTLR4 and sTREM-1 in Knee Osteoarthritis: Associations with Study-Specific MRI-Defined Categories and Disease Burden. | J Clin Med | 2026 | 42739905 | PubTator, text mining | PubMed |
| An analysis of cerebral amyloid angiopathy based on samples from human brain bank. | Front Immunol | 2026 | 42682443 | PubTator, text mining | PubMed |
1 to 10 of 3,294
See all 3,294 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/54210
GET https://conductscience.org/api/genes/v1/54210/patents?page=2