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Gene · 54583

EGLN1: egl-9 family hypoxia inducible factor 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. EGLN1: egl-9 family hypoxia inducible factor 1. Genes, record 54583. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/54583

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Gene

Symbol
EGLN1
HGNC
Name
egl-9 family hypoxia inducible factor 1
HGNC
NCBI Gene ID
54583
NCBI Gene
HGNC ID
HGNC:1232
HGNC
Ensembl
ENSG00000135766
NCBI Gene
Aliases
C1orf12, ECYT3, HALAH, HIF-PH2, HIFPH2, HPH-2, HPH2, PHD2, SM-20, SM20, ZMYND6
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9GZT9Egl nine homolog 142664Ensembl, GeneID, HGNC

Source UniProt

Patents51

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1444805Q9GZT9Espacenet
EP 4663754 A22025-12-1713Q9GZT9Espacenet
EP 4650780 A22025-11-198089Q9GZT9Espacenet
JP 2025517970 A2025-06-128089Q9GZT9Espacenet
EP 4491229 A22025-01-1568Q9GZT9Espacenet
WO 2024230934 A12024-11-14193Q9GZT9Espacenet
US 11446398 B22022-09-2026827Q9GZT9Espacenet
JP 2022524081 A2022-04-27129798Q9GZT9Espacenet
US 11078247 B22021-08-033428Q9GZT9Espacenet
WO 2020161342 A12020-08-1368Q9GZT9Espacenet

1 to 10 of 51

See all 51 patents

Drugs5

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
DAPRODUSTATCHEMBL3544988Hypoxia-inducible factor prolyl hydroxylase inhibitorINHIBITORChEMBL
ENARODUSTATCHEMBL4297619Egl nine homolog 1 inhibitorINHIBITORChEMBL
MOLIDUSTATCHEMBL3646118Egl nine homolog 1 inhibitorINHIBITORChEMBL
ROXADUSTATCHEMBL2338329Hypoxia-inducible factor prolyl hydroxylase inhibitorINHIBITORChEMBL
VADADUSTATCHEMBL3646221Egl nine homolog 1 inhibitorINHIBITORChEMBL

Trials116

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

1 to 10 of 116

See all 116 trials

NIH grants1,902

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleEGLN1 papersNewest fiscal year
P01CA108671Myeloproliferative Neoplasms-Research Consortium122025
P30CA008748Cancer Center Support Grant122025
P30CA016672Cancer Center Support Grant112025
P30CA046934University of Colorado Cancer Center Support Grant82025
P30CA060553The Robert H. Lurie Comprehensive Cancer Center72025
P30CA086862Cancer Center Support Grant72025
P50CA101942DF/HCC Kidney Cancer SPORE (supplement)72025
ZIABC011773Hypoxia signaling in cancer development62025
P30CA016056Roswell Park Cancer Center Support Grant52025
P30CA016086Cancer Center Support Grant52025

1 to 10 of 1,902Source NIH's project files

See all 1,902 nih grants

Papers3,727

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
CCN1 upregulation in diabetic wounds suppresses PINK1/Parkin-mediated mitophagy in dermal fibroblasts by regulating HIF-1α protein stability under decompensated hypoxic conditions.Cell Signal202642802000PubTator, text miningPubMed
PGC1α-mediated upregulation of PHD2 represses HIF-signaling, limiting prostate cancer progression.Cell Death Differ202642754649PubTator, text miningPubMed
Current insights into PHF14: molecular features and functional roles.Front Mol Biosci202642698416PubTator, text miningPubMed
ERN1 inhibition modifies hypoxic regulation of EGLN1 expression in U87MG glioblastoma cells.Endocr Regul202642672129PubTator, text miningPubMed
Plant-Based α-Linolenic Acid as a Superior Nutraceutical to Modulates Apoptosis, Hypoxic Signaling, and Lipid Metabolic Pathway in Breast Cancer: A Comparative Preclinical Study.Mol Nutr Food Res202642671985PubTator, text miningPubMed
Genetic Modifiers of Cardiac Remodeling Severity in IVS4+919G>A-Associated Fabry Cardiomyopathy.Int J Mol Sci202642653448PubTator, text miningPubMed
Development of endothelial injury under chemical hypoxia: early migration impairment precedes cytotoxicity in CoCl2-treated EA.hy926 cells.Mol Biol Rep202642631778PubTator, text miningPubMed
Fluoride induced chondrocyte extracellular matrix degradation by inhibition of glycolysis by the PHD2/HIF1α signaling pathway.Environ Toxicol Pharmacol202642628705PubTator, text miningPubMed
Methylglyoxal Attenuates Mycobacterium avium subspecies paratuberculosis (MAP)-Induced Pro-Inflammatory Macrophage Programming Associated with NRF-2 Antioxidant Responses and Reduced MCT4/Lactate-Linked Inflammatory Markers.
Int J Mol Sci202642589594PubTator, text miningPubMed
Familial erythrocytosis associated with an EGLN1 (PHD2) variant of uncertain significance with emerging evidence of pathogenicity.BMJ Case Rep202642586595PubTator, text miningPubMed

1 to 10 of 3,727

See all 3,727 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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