Gene · 54795
TRPM4: transient receptor potential cation channel subfamily M member 4
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. TRPM4: transient receptor potential cation channel subfamily M member 4. Genes, record 54795. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/54795
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q8TD43 | Transient receptor potential cation channel subfamily M member 4 | 1,214 | 42 | Ensembl, GeneID, HGNC |
Source UniProt
Patents96
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| WO 2026063308 A | 2026-03-26 | 14 | Q8TD43 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 67630 | Q8TD43 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 1414 | Q8TD43 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 1044 | Q8TD43 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 5071 | Q8TD43 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 5071 | Q8TD43 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 1044 | Q8TD43 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 1414 | Q8TD43 | Espacenet |
| US 12121590 B2 | 2024-10-22 | 68 | Q8TD43 | Espacenet |
| US 11759531 B2 | 2023-09-19 | 110 | Q8TD43 | Espacenet |
1 to 10 of 96
See all 96 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants793
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | TRPM4 papers | Newest fiscal year |
|---|---|---|---|
| R01NS115815 | A Translational Evaluation of Sur1-Trpm4 Imaging Endophenotypes and Genetics to Direct Precision Medicine for Cerebral Edema After Traumatic Brain Injury | 7 | 2025 |
| P20GM130459 | Nevada Center of Biomedical Research Excellence in Molecular and Cellular Signal Transduction in the Cardiovascular System | 6 | 2025 |
| UL1TR001863 | Yale Clinical and Translational Science Award | 6 | 2025 |
| U24NS107215 | Southern New England Partnership In Stroke Research, Innovation and Treatment (SPIRIT) | 5 | 2025 |
| P20GM103466 | HAWAII INBRE V PROGRAM | 4 | 2025 |
| R01GM093290 | Regulation of the epithelial Ca2+ channels TRPV6 and TRPV5 | 4 | 2025 |
| R35HL155008 | TRP channels as fundamental sensors of the cerebral microcirculation | 4 | 2025 |
| T32HD040686 | Pediatric Neurointensive Care and Resuscitation Research | 4 | 2025 |
| R01CA206573 | Structure and function of Transient Receptor Potential Channels | 3 | 2025 |
| R01DK095045 | Molecular mechanisms of podocyte injury in FSGS | 3 | 2025 |
1 to 10 of 793Source NIH's project files
See all 793 nih grantsPapers1,538
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| TRPM4 contributes to the formation and outgrowth of Dukes' stage C colorectal cancer tumor spheroids. | Cell Calcium | 2026 | 42815047 | PubTator, text mining | PubMed |
| Genetic loci responsible for atrioventricular block in children. | Front Cell Dev Biol | 2026 | 42798645 | PubTator, text mining | PubMed |
| Structural biology of the TRPM4 channel: architecture, modulation, and therapeutic opportunities. | Front Pharmacol | 2026 | 42787536 | PubTator, text mining | PubMed |
| Necrosis by Sodium Overload: Mechanisms, Pathophysiological Roles, and Therapeutic Prospects of a Novel Form of Regulated Cell Death. | Cell Biochem Biophys | 2026 | 42709394 | PubTator, text mining | PubMed |
| Construction of molecular signatures based on the co-expression network of NECSO-related gene TRPM4 and its prognostic value in hepatocellular carcinoma. | J Gastrointest Oncol | 2026 | 42703320 | PubTator, text mining | PubMed |
| Carrier-as-Prodrug Glycyrrhizic Acid Nanogel Co-Delivers Mannose and Glycyrrhetinic Acid for Metabolic-Ionic Cancer Therapy. | ACS Appl Mater Interfaces | 2026 | 42670768 | PubTator, text mining | PubMed |
| Integrated Analysis Identifies a TRPM4-Related Sodium Overload Signature with Prognostic Value and Experimentally Validates RNPEPL1 in Lung Adenocarcinoma. | Cancers (Basel) | 2026 | 42649955 | PubTator, text mining | PubMed |
| HOXC4 as a machine learning-derived immune biomarker for predicting treatment and prognosis in prostate cancer patients. | Transl Androl Urol | 2026 | 42582767 | PubTator, text mining | PubMed |
| NECSO-based classification predicts immunotherapy efficacy and identifies FLAD1 as therapeutic target in kidney renal clear cell carcinoma. | Front Immunol | 2026 | 42582320 | PubTator, text mining | PubMed |
| [Role of programmed cell death in platinum resistance in ovarian cancer]. | Zhong Nan Da Xue Xue Bao Yi Xue Ban | 2026 | 42565580 | PubTator, text mining | PubMed |
1 to 10 of 1,538
See all 1,538 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
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The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/54795
GET https://conductscience.org/api/genes/v1/54795/patents?page=2