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Gene · 54795

TRPM4: transient receptor potential cation channel subfamily M member 4

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. TRPM4: transient receptor potential cation channel subfamily M member 4. Genes, record 54795. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/54795

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Gene

Symbol
TRPM4
HGNC
Name
transient receptor potential cation channel subfamily M member 4
HGNC
NCBI Gene ID
54795
NCBI Gene
HGNC ID
HGNC:17993
HGNC
Ensembl
ENSG00000130529
NCBI Gene
Aliases
EKVP6, FLJ20041, LTrpC4, PFHB1B, TRPM4B, hTRPM4
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q8TD43Transient receptor potential cation channel subfamily M member 41,21442Ensembl, GeneID, HGNC

Source UniProt

Patents96

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
WO 2026063308 A2026-03-2614Q8TD43Espacenet
JP 2026004568 A2026-01-1467630Q8TD43Espacenet
EP 4650780 A22025-11-191414Q8TD43Espacenet
EP 4641201 A22025-10-291044Q8TD43Espacenet
JP 2025529142 A2025-09-045071Q8TD43Espacenet
US 12371689 B22025-07-295071Q8TD43Espacenet
JP 2025517969 A2025-06-121044Q8TD43Espacenet
JP 2025517970 A2025-06-121414Q8TD43Espacenet
US 12121590 B22024-10-2268Q8TD43Espacenet
US 11759531 B22023-09-19110Q8TD43Espacenet

1 to 10 of 96

See all 96 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants793

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTRPM4 papersNewest fiscal year
R01NS115815A Translational Evaluation of Sur1-Trpm4 Imaging Endophenotypes and Genetics to Direct Precision Medicine for Cerebral Edema After Traumatic Brain Injury72025
P20GM130459Nevada Center of Biomedical Research Excellence in Molecular and Cellular Signal Transduction in the Cardiovascular System62025
UL1TR001863Yale Clinical and Translational Science Award62025
U24NS107215Southern New England Partnership In Stroke Research, Innovation and Treatment (SPIRIT)52025
P20GM103466HAWAII INBRE V PROGRAM42025
R01GM093290Regulation of the epithelial Ca2+ channels TRPV6 and TRPV542025
R35HL155008TRP channels as fundamental sensors of the cerebral microcirculation42025
T32HD040686Pediatric Neurointensive Care and Resuscitation Research42025
R01CA206573Structure and function of Transient Receptor Potential Channels32025
R01DK095045Molecular mechanisms of podocyte injury in FSGS32025

1 to 10 of 793Source NIH's project files

See all 793 nih grants

Papers1,538

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
TRPM4 contributes to the formation and outgrowth of Dukes' stage C colorectal cancer tumor spheroids.Cell Calcium202642815047PubTator, text miningPubMed
Genetic loci responsible for atrioventricular block in children.Front Cell Dev Biol202642798645PubTator, text miningPubMed
Structural biology of the TRPM4 channel: architecture, modulation, and therapeutic opportunities.Front Pharmacol202642787536PubTator, text miningPubMed
Necrosis by Sodium Overload: Mechanisms, Pathophysiological Roles, and Therapeutic Prospects of a Novel Form of Regulated Cell Death.Cell Biochem Biophys202642709394PubTator, text miningPubMed
Construction of molecular signatures based on the co-expression network of NECSO-related gene TRPM4 and its prognostic value in hepatocellular carcinoma.J Gastrointest Oncol202642703320PubTator, text miningPubMed
Carrier-as-Prodrug Glycyrrhizic Acid Nanogel Co-Delivers Mannose and Glycyrrhetinic Acid for Metabolic-Ionic Cancer Therapy.ACS Appl Mater Interfaces202642670768PubTator, text miningPubMed
Integrated Analysis Identifies a TRPM4-Related Sodium Overload Signature with Prognostic Value and Experimentally Validates RNPEPL1 in Lung Adenocarcinoma.Cancers (Basel)202642649955PubTator, text miningPubMed
HOXC4 as a machine learning-derived immune biomarker for predicting treatment and prognosis in prostate cancer patients.Transl Androl Urol202642582767PubTator, text miningPubMed
NECSO-based classification predicts immunotherapy efficacy and identifies FLAD1 as therapeutic target in kidney renal clear cell carcinoma.Front Immunol202642582320PubTator, text miningPubMed
[Role of programmed cell death in platinum resistance in ovarian cancer].Zhong Nan Da Xue Xue Bao Yi Xue Ban202642565580PubTator, text miningPubMed

1 to 10 of 1,538

See all 1,538 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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