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Gene · 54915

YTHDF1: YTH N6-methyladenosine RNA binding protein F1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. YTHDF1: YTH N6-methyladenosine RNA binding protein F1. Genes, record 54915. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/54915

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Gene

Symbol
YTHDF1
HGNC
Name
YTH N6-methyladenosine RNA binding protein F1
HGNC
NCBI Gene ID
54915
NCBI Gene
HGNC ID
HGNC:15867
HGNC
Ensembl
ENSG00000149658
NCBI Gene
Aliases
C20orf21, DF1, FLJ20391
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9BYJ9YTH domain-containing family protein 155910Ensembl, GeneID, HGNC

Source UniProt

Patents28

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4641201 A22025-10-298958Q9BYJ9Espacenet
JP 2025517969 A2025-06-128958Q9BYJ9Espacenet
JP 2025024198 A2025-02-1917400Q9BYJ9Espacenet
JP 2023537210 A2023-08-313Q9BYJ9Espacenet
JP 2023522957 A2023-06-019Q9BYJ9Espacenet
US 11446398 B22022-09-2098265Q9BYJ9Espacenet
JP 2022524081 A2022-04-27201236Q9BYJ9Espacenet
US 10677795 B22020-06-09740Q9BYJ9Espacenet
WO 2020043864 A12020-03-052857Q9BYJ9Espacenet
US 9827332 B22017-11-2817400Q9BYJ9Espacenet

1 to 10 of 28

See all 28 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants766

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleYTHDF1 papersNewest fiscal year
RM1HG008935Center for dynamic RNA epitranscriptomes - Renewal272025
R01CA186702Mechanisms of epitranscriptomic regulation in cancer92025
P30CA014599Cancer Center Support Grant82025
R01AI125416Defining the role of the RNA modification N6-methyladenosine during Flaviviridae virus infection62025
P30AI064518Center for AIDS Research52025
P30ES027792ChicAgo Center for Health and EnvironmenT (CACHET)52025
R35NS111631New mechanisms and technologies for understanding post-transcriptional gene regulation in neurons52025
R01GM056927Control of Translation in Herpesvirus Infected Cells - Resubmission - 142025
T32AI007647Training Program in Mechanisms of Virus-Host Interactions42025
P30CA016059Massey Cancer Center - Cancer Center Support Grant32025

1 to 10 of 766Source NIH's project files

See all 766 nih grants

Papers3,036

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Single residues within the YTHDF intrinsically disordered region control m 6 A-dependent mRNA decay.bioRxiv202642818126PubTator, text miningPubMed
Epitranscriptomic regulation of Notch signaling.Cell Signal202642800623PubTator, text miningPubMed
METTL3‑mediated OTUB1 sustains PD‑L1 protein stability via deubiquitination and promotes immune evasion in oral squamous cell carcinoma.Mol Cell Biochem202642776380PubTator, text miningPubMed
Lactylation and N6-Methyladenosine RNA modification in neuropsychiatric sequelae after intracerebral hemorrhage: a hypothesis-generating metabolic-glial-circuit framework.Mol Biol Rep202642730969PubTator, text miningPubMed
NBR1-Mediated Autophagic Degradation of YTHDF1 Curtails FDX1 Translation to Drive Concurrent Multikinase Inhibitor Resistance and Cuproptosis Tolerance.Cancer Commun (Lond)202642729649PubTator, text miningPubMed
Mutant KRAS-m6A Epitranscriptome Axis Promotes Colorectal Cancer and is a Therapeutic Target.Adv Sci (Weinh)202642717493PubTator, text miningPubMed
Development of m6A Readers for Enhanced Recognition In Vitro via Genetic Code Expansion.ACS Chem Biol202642715419PubTator, text miningPubMed
RNA m⁶A modification and its regulatory factors are altered in granulosa cells from women with PMOS.J Assist Reprod Genet202642687053PubTator, text miningPubMed
YTHDF1-mediated m6A RNA regulation controls cardiomyocyte remodeling through KLF11-HIF1α.Proc Natl Acad Sci U S A202642679039PubTator, text miningPubMed
Single-cell RNA sequencing uncovers m6A regulator-defined T-cell subpopulations and YTHDF1-HSP90AB1-MYC therapeutic axis in T-cell acute lymphoblastic leukemia.Chin Med J (Engl)202642675534PubTator, text miningPubMed

1 to 10 of 3,036

See all 3,036 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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