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Gene · 5515

PPP2CA: protein phosphatase 2 catalytic subunit alpha

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PPP2CA: protein phosphatase 2 catalytic subunit alpha. Genes, record 5515. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5515

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Gene

Symbol
PPP2CA
HGNC
Name
protein phosphatase 2 catalytic subunit alpha
HGNC
NCBI Gene ID
5515
NCBI Gene
HGNC ID
HGNC:9299
HGNC
Ensembl
ENSG00000113575
NCBI Gene
Aliases
HJS3, NEDLBA, PP2AC, PP2Ac, PP2CA, PP2Calpha, RP-C
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P67775Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform30950Ensembl, GeneID, HGNC

Source UniProt

Patents50

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4805736 A22026-09-1629P67775Espacenet
JP 2026004568 A2026-01-1459942P67775Espacenet
EP 4650780 A22025-11-1914210P67775Espacenet
JP 2025517970 A2025-06-1214210P67775Espacenet
JP 2025032204 A2025-03-1133972P67775Espacenet
EP 4461818 A22024-11-1333972P67775Espacenet
US 11708396 B22023-07-251893P67775Espacenet
JP 2023058610 A2023-04-2533972P67775Espacenet
US 11446398 B22022-09-2068686P67775Espacenet
JP 2022524081 A2022-04-27171657P67775Espacenet

1 to 10 of 50

See all 50 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
LB-100CHEMBL4297300Serine/threonine protein phosphatase 2A, catalytic subunit, alpha isoform inhibitorINHIBITOR

Source ChEMBL

Trials6

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT06065462LB-100PHASE1/PHASE2ClinicalTrials.gov
NCT06012734LB-100PHASE1ClinicalTrials.gov
NCT05809830LB-100PHASE1/PHASE2ClinicalTrials.gov
NCT04560972LB-100PHASE1ClinicalTrials.gov
NCT03886662LB-100PHASE1/PHASE2ClinicalTrials.gov
NCT01837667LB-100PHASE1ClinicalTrials.gov

NIH grants2,306

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePPP2CA papersNewest fiscal year
P30CA016672Cancer Center Support Grant162025
P30CA008748Cancer Center Support Grant142025
P01CA092584Structural Cell Biology of DNA Repair Machines132025
P30CA068485Cancer Center Support Grant132025
R35GM119455Mechanisms of Phosphorylation Signaling by Phosphoprotein Phosphatases112025
P01CA013106Targeting Transcription and Splicing in Cancer72025
P20GM113132The Institute for Biomolecular Targeting62025
P30CA006927Comprehensive Cancer Center Program at Fox Chase62025
P30CA023108Cancer Center Support Grant52025
P30CA036727Buffett Cancer Center Support Grant52025

1 to 10 of 2,306Source NIH's project files

See all 2,306 nih grants

Papers3,188

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
HIF-1-mediated PPME1 expression promotes breast cancer progression via AKT activation and β-catenin recruitment.J Clin Invest202642820287PubTator, text miningPubMed
A case report of a novel de novo variant in PPP2CA causing a neurodevelopmental disorder and epilepsy.Front Psychiatry202642630699PubTator, text miningPubMed
A PP2A phosphatase-defined transcriptional activity window safeguards male fertility.Plant Cell202642574602PubTator, text miningPubMed
Study of post-translational modifications of p53 in multiple myeloma.Blood Cancer J202642469225PubTator, text miningPubMed
The Protein Phosphatase Inhibitor LB100 Targets the Mesenchymal Lineage of Pancreatic Ductal Adenocarcinoma.MedComm (2020)202642266180PubTator, text miningPubMed
Correction: Colchicine inhibits vascular calcification by suppressing inflammasome activation through the enhancement of the Sirt2-PP2Ac signaling pathway.J Biol Chem202642242025PubTator, text miningPubMed
CYP2A13 upregulation contributes to lung tumorigenesis upon NNK exposure.Ecotoxicol Environ Saf202642217486PubTator, text miningPubMed
Mts/PP2AC Induces Cell Migration via Rho1-Slpr-Mediated JNK Pathway.FASEB J202642144974PubTator, text miningPubMed
Regulation between LRRK2 and PP2A signaling in cellular models of Parkinson's disease.Biochem J202642133347PubTator, text miningPubMed
Synthesis and characterization of L-3-(pentafluorophosphato-difluoromethyl)-alanine, a structural and functional mimetic of phosphoserine.Chem Commun (Camb)202642132578PubTator, text miningPubMed

1 to 10 of 3,188

See all 3,188 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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