Gene · 5515
PPP2CA: protein phosphatase 2 catalytic subunit alpha
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. PPP2CA: protein phosphatase 2 catalytic subunit alpha. Genes, record 5515. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5515
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P67775 | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform | 309 | 50 | Ensembl, GeneID, HGNC |
Source UniProt
Patents50
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4805736 A2 | 2026-09-16 | 29 | P67775 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 59942 | P67775 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 14210 | P67775 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 14210 | P67775 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 33972 | P67775 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 33972 | P67775 | Espacenet |
| US 11708396 B2 | 2023-07-25 | 1893 | P67775 | Espacenet |
| JP 2023058610 A | 2023-04-25 | 33972 | P67775 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 68686 | P67775 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 171657 | P67775 | Espacenet |
1 to 10 of 50
See all 50 patentsDrugs1
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action |
|---|---|---|---|
| LB-100 | CHEMBL4297300 | Serine/threonine protein phosphatase 2A, catalytic subunit, alpha isoform inhibitor | INHIBITOR |
Source ChEMBL
Trials6
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT06065462 | LB-100 | PHASE1/PHASE2 | ClinicalTrials.gov | |
| NCT06012734 | LB-100 | PHASE1 | ClinicalTrials.gov | |
| NCT05809830 | LB-100 | PHASE1/PHASE2 | ClinicalTrials.gov | |
| NCT04560972 | LB-100 | PHASE1 | ClinicalTrials.gov | |
| NCT03886662 | LB-100 | PHASE1/PHASE2 | ClinicalTrials.gov | |
| NCT01837667 | LB-100 | PHASE1 | ClinicalTrials.gov |
NIH grants2,306
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | PPP2CA papers | Newest fiscal year |
|---|---|---|---|
| P30CA016672 | Cancer Center Support Grant | 16 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 14 | 2025 |
| P01CA092584 | Structural Cell Biology of DNA Repair Machines | 13 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 13 | 2025 |
| R35GM119455 | Mechanisms of Phosphorylation Signaling by Phosphoprotein Phosphatases | 11 | 2025 |
| P01CA013106 | Targeting Transcription and Splicing in Cancer | 7 | 2025 |
| P20GM113132 | The Institute for Biomolecular Targeting | 6 | 2025 |
| P30CA006927 | Comprehensive Cancer Center Program at Fox Chase | 6 | 2025 |
| P30CA023108 | Cancer Center Support Grant | 5 | 2025 |
| P30CA036727 | Buffett Cancer Center Support Grant | 5 | 2025 |
1 to 10 of 2,306Source NIH's project files
See all 2,306 nih grantsPapers3,188
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| HIF-1-mediated PPME1 expression promotes breast cancer progression via AKT activation and β-catenin recruitment. | J Clin Invest | 2026 | 42820287 | PubTator, text mining | PubMed |
| A case report of a novel de novo variant in PPP2CA causing a neurodevelopmental disorder and epilepsy. | Front Psychiatry | 2026 | 42630699 | PubTator, text mining | PubMed |
| A PP2A phosphatase-defined transcriptional activity window safeguards male fertility. | Plant Cell | 2026 | 42574602 | PubTator, text mining | PubMed |
| Study of post-translational modifications of p53 in multiple myeloma. | Blood Cancer J | 2026 | 42469225 | PubTator, text mining | PubMed |
| The Protein Phosphatase Inhibitor LB100 Targets the Mesenchymal Lineage of Pancreatic Ductal Adenocarcinoma. | MedComm (2020) | 2026 | 42266180 | PubTator, text mining | PubMed |
| Correction: Colchicine inhibits vascular calcification by suppressing inflammasome activation through the enhancement of the Sirt2-PP2Ac signaling pathway. | J Biol Chem | 2026 | 42242025 | PubTator, text mining | PubMed |
| CYP2A13 upregulation contributes to lung tumorigenesis upon NNK exposure. | Ecotoxicol Environ Saf | 2026 | 42217486 | PubTator, text mining | PubMed |
| Mts/PP2AC Induces Cell Migration via Rho1-Slpr-Mediated JNK Pathway. | FASEB J | 2026 | 42144974 | PubTator, text mining | PubMed |
| Regulation between LRRK2 and PP2A signaling in cellular models of Parkinson's disease. | Biochem J | 2026 | 42133347 | PubTator, text mining | PubMed |
| Synthesis and characterization of L-3-(pentafluorophosphato-difluoromethyl)-alanine, a structural and functional mimetic of phosphoserine. | Chem Commun (Camb) | 2026 | 42132578 | PubTator, text mining | PubMed |
1 to 10 of 3,188
See all 3,188 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/5515
GET https://conductscience.org/api/genes/v1/5515/patents?page=2