Gene · 55626
AMBRA1: autophagy and beclin 1 regulator 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. AMBRA1: autophagy and beclin 1 regulator 1. Genes, record 55626. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/55626
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q9C0C7 | Activating molecule in BECN1-regulated autophagy protein 1 | 1,298 | 2 | Ensembl, GeneID, HGNC |
Source UniProt
Patents19
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 38540 | Q9C0C7 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 13946 | Q9C0C7 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 16196 | Q9C0C7 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 16196 | Q9C0C7 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 13946 | Q9C0C7 | Espacenet |
| US 12275780 B2 | 2025-04-15 | 21 | Q9C0C7 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 8098 | Q9C0C7 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 8098 | Q9C0C7 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 111069 | Q9C0C7 | Espacenet |
| WO 2021023962 A1 | 2021-02-11 | 21 | Q9C0C7 | Espacenet |
1 to 10 of 19
See all 19 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants874
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | AMBRA1 papers | Newest fiscal year |
|---|---|---|---|
| R01AG011085 | Ubiquitin‐mediated proteolysis and cell cycle control | 6 | 2025 |
| R35GM131919 | The mechanism and regulation of autophagy | 6 | 2025 |
| P30AI027763 | UCSF-Bay Area Center for AIDS Research | 4 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 4 | 2025 |
| R01CA126792 | Autophagy and Pro-metastatic Differentiation | 4 | 2025 |
| R01NS060123 | Neuronal Autophagy: a Cell-Autonomous Protection Mechanism | 4 | 2025 |
| R35GM136250 | Regulation of cell proliferation by CRL ubiquitin ligases | 4 | 2025 |
| P01AI063302 | The intersection of innate and adaptive immunity to intracellular pathogens | 3 | 2025 |
| P30CA016087 | Cancer Center Support Grant | 3 | 2025 |
| P30DK020579 | Diabetes Research Center | 3 | 2025 |
1 to 10 of 874Source NIH's project files
See all 874 nih grantsPapers1,468
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Spatial control of mitochondrial ubiquitination by the AMBRA1-RMC1-HUWE1 axis. | Autophagy | 2026 | 42747977 | PubTator, text mining | PubMed |
| Genome-wide CRISPR screen identifies AMBRA1 as a potential biomarker of response to platinum-based therapies in oral squamous cell carcinomas. | iScience | 2026 | 42548798 | PubTator, text mining | PubMed |
| Targeting Tex10 Overcomes Oxaliplatin Resistance by Competitively Disrupting the Non-Canonical BAF Complex in Colorectal Cancer. | Adv Sci (Weinh) | 2026 | 42525468 | PubTator, text mining | PubMed |
| Role of Autophagy in Goose Astrovirus-Induced Renal Injury in Goslings. | Animals (Basel) | 2026 | 42511092 | PubTator, text mining | PubMed |
| Utility of Combined Immunohistochemical Staining for AMBRA1 and Loricrin for Improving the Pathologic Diagnosis of High-Grade Dysplastic Nevi. | Am J Dermatopathol | 2026 | 42358006 | PubTator, text mining | PubMed |
| Ubiquitin-dependent degradation of p27Kip1 and p21Waf1/Cip1 by AMBRA1 ensures G1 and S phase progression and limits replication stress. | Nucleic Acids Res | 2026 | 42339621 | PubTator, text mining | PubMed |
| The Origin and Application of Cardiomyocyte-Derived Small Extracellular Vesicles: A Systematic Review. | Int J Med Sci | 2026 | 42328115 | PubTator, text mining | PubMed |
| Mitophagy mitigates tau acetylation via the ULK1-NAD+/SIRT1 axis in Alzheimer's disease. | Autophagy | 2026 | 42323822 | PubTator, text mining | PubMed |
| Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells. | FEBS Open Bio | 2026 | 42231548 | PubTator, text mining | PubMed |
| Trifloxystrobin-triggered Drp1 hyperactivation biases mitophagy and imposes long-lasting SVCV susceptibility in teleost. | J Virol | 2026 | 42223444 | PubTator, text mining | PubMed |
1 to 10 of 1,468
See all 1,468 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
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The record and each of its lists are JSON, twenty rows a page. No key.
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GET https://conductscience.org/api/genes/v1/55626/patents