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Gene · 55626

AMBRA1: autophagy and beclin 1 regulator 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. AMBRA1: autophagy and beclin 1 regulator 1. Genes, record 55626. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/55626

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Gene

Symbol
AMBRA1
HGNC
Name
autophagy and beclin 1 regulator 1
HGNC
NCBI Gene ID
55626
NCBI Gene
HGNC ID
HGNC:25990
HGNC
Ensembl
ENSG00000110497
NCBI Gene
Aliases
DCAF3, FLJ20294, KIAA1736, WDR94
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9C0C7Activating molecule in BECN1-regulated autophagy protein 11,2982Ensembl, GeneID, HGNC

Source UniProt

Patents19

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1438540Q9C0C7Espacenet
EP 4650780 A22025-11-1913946Q9C0C7Espacenet
EP 4641201 A22025-10-2916196Q9C0C7Espacenet
JP 2025517969 A2025-06-1216196Q9C0C7Espacenet
JP 2025517970 A2025-06-1213946Q9C0C7Espacenet
US 12275780 B22025-04-1521Q9C0C7Espacenet
JP 2025062604 A2025-04-148098Q9C0C7Espacenet
US 11446398 B22022-09-208098Q9C0C7Espacenet
JP 2022524081 A2022-04-27111069Q9C0C7Espacenet
WO 2021023962 A12021-02-1121Q9C0C7Espacenet

1 to 10 of 19

See all 19 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants874

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleAMBRA1 papersNewest fiscal year
R01AG011085Ubiquitin‐mediated proteolysis and cell cycle control62025
R35GM131919The mechanism and regulation of autophagy62025
P30AI027763UCSF-Bay Area Center for AIDS Research42025
P30CA016672Cancer Center Support Grant42025
R01CA126792Autophagy and Pro-metastatic Differentiation42025
R01NS060123Neuronal Autophagy: a Cell-Autonomous Protection Mechanism42025
R35GM136250Regulation of cell proliferation by CRL ubiquitin ligases42025
P01AI063302The intersection of innate and adaptive immunity to intracellular pathogens32025
P30CA016087Cancer Center Support Grant32025
P30DK020579Diabetes Research Center32025

1 to 10 of 874Source NIH's project files

See all 874 nih grants

Papers1,468

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Spatial control of mitochondrial ubiquitination by the AMBRA1-RMC1-HUWE1 axis.Autophagy202642747977PubTator, text miningPubMed
Genome-wide CRISPR screen identifies AMBRA1 as a potential biomarker of response to platinum-based therapies in oral squamous cell carcinomas.iScience202642548798PubTator, text miningPubMed
Targeting Tex10 Overcomes Oxaliplatin Resistance by Competitively Disrupting the Non-Canonical BAF Complex in Colorectal Cancer.Adv Sci (Weinh)202642525468PubTator, text miningPubMed
Role of Autophagy in Goose Astrovirus-Induced Renal Injury in Goslings.Animals (Basel)202642511092PubTator, text miningPubMed
Utility of Combined Immunohistochemical Staining for AMBRA1 and Loricrin for Improving the Pathologic Diagnosis of High-Grade Dysplastic Nevi.Am J Dermatopathol202642358006PubTator, text miningPubMed
Ubiquitin-dependent degradation of p27Kip1 and p21Waf1/Cip1 by AMBRA1 ensures G1 and S phase progression and limits replication stress.Nucleic Acids Res202642339621PubTator, text miningPubMed
The Origin and Application of Cardiomyocyte-Derived Small Extracellular Vesicles: A Systematic Review.Int J Med Sci202642328115PubTator, text miningPubMed
Mitophagy mitigates tau acetylation via the ULK1-NAD+/SIRT1 axis in Alzheimer's disease.Autophagy202642323822PubTator, text miningPubMed
Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells.FEBS Open Bio202642231548PubTator, text miningPubMed
Trifloxystrobin-triggered Drp1 hyperactivation biases mitophagy and imposes long-lasting SVCV susceptibility in teleost.J Virol202642223444PubTator, text miningPubMed

1 to 10 of 1,468

See all 1,468 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

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GET https://conductscience.org/api/genes/v1/55626/patents