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Gene · 5566

PRKACA: protein kinase cAMP-activated catalytic subunit alpha

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PRKACA: protein kinase cAMP-activated catalytic subunit alpha. Genes, record 5566. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5566

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Gene

Symbol
PRKACA
HGNC
Name
protein kinase cAMP-activated catalytic subunit alpha
HGNC
NCBI Gene ID
5566
NCBI Gene
HGNC ID
HGNC:9380
HGNC
Ensembl
ENSG00000072062
NCBI Gene
Aliases
CAFD1, PKACA, PKACa, PPNAD4
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P17612cAMP-dependent protein kinase catalytic subunit alpha35154Ensembl, GeneID, HGNC

Source UniProt

Patents73

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026082831 A2026-05-191P17612Espacenet
EP 4694917 A12026-02-18637P17612Espacenet
JP 2026004568 A2026-01-1459765P17612Espacenet
JP 2026004568 A2026-01-1459767P17612Espacenet
WO 2025252547 A12025-12-11111P17612Espacenet
EP 4660322 A12025-12-10111P17612Espacenet
EP 4650780 A22025-11-194635P17612Espacenet
US 12473332 B22025-11-181P17612Espacenet
JP 2025517970 A2025-06-124635P17612Espacenet
WO 2025016918 A12025-01-23111P17612Espacenet

1 to 10 of 73

See all 73 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
GSK-690693CHEMBL494089cAMP-dependent protein kinase (PKA) inhibitorINHIBITOR

Source ChEMBL

Trials2

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT00666081GSK-690693PHASE1ClinicalTrials.gov
NCT00493818GSK-690693PHASE1ClinicalTrials.gov

NIH grants1,878

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePRKACA papersNewest fiscal year
P30CA008748Cancer Center Support Grant232025
P50CA210964Mayo Clinic Hepatobiliary SPORE172025
P30CA016672Cancer Center Support Grant162025
UL1TR001866Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational Success122025
P30CA068485Cancer Center Support Grant62025
R01DK119192Defective PKA Signaling in Cushing's Syndrome62025
R35GM130389Lessons Learned from PKA: Assembly of Dynamic Macromolecular Switches62025
U54GM115428Mississippi Center for Clinical and Translational Research52025
P30CA015083Mayo Clinic Comprehensive Cancer Center Support Grant42025
P30CA046592University of Michigan Rogel Cancer Center Support Grant 2023-202842025

1 to 10 of 1,878Source NIH's project files

See all 1,878 nih grants

Papers2,763

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Screening of Programmed Cell Death-Related Biomarkers and Exploration of Mechanisms in Zhenwu Decoction for Treating Chronic Kidney Disease.Comb Chem High Throughput Screen202642817110PubTator, text miningPubMed
Quercetin, an active component of Qiu's HuaShi decoction, suppresses glycolysis in cervical epithelial cells to reduce HPV infection via modulating the PRKACA/cAMP/PKA/CREB pathway.Biochim Biophys Acta Gen Subj202642805466PubTator, text miningPubMed
A parsimonious three-gene mitochondrial classifier from frontal cortex for Alzheimer's disease: Nested cross-validation and multicenter external validation.J Alzheimers Dis202642742534PubTator, text miningPubMed
Exploring the therapeutic potential of Astragalin in Parkinson's disease: a network pharmacology approach.Ann Med Surg (Lond)202642724825PubTator, text miningPubMed
Association between HOMA-IR and coexisting MASLD and type 2 diabetes: Insights from NHANES and network pharmacology.Ther Adv Endocrinol Metab202642719461PubTator, text miningPubMed
[Fibrolamellar hepatocellular carcinoma: a clinicopathological and molecular genetic analysis of nine cases].Zhonghua Bing Li Xue Za Zhi202642706111PubTator, text miningPubMed
The identification of a PRKACA duplication at 19p13.12 in a female with PPNAD and thyroid carcinoma after a 20-year diagnostic journey.Fam Cancer202642667476PubTator, text miningPubMed
Deciphering the Molecular Basis: Integrative Multi-Method Analysis of Bioactive Constituents and Their Anti-Lung Cancer Mechanisms in Clinical Traditional Chinese Medicine Formulations.Chem Biodivers202642607109PubTator, text miningPubMed
Management of rare primary liver cancers: combined hepato-cholangiocarcinoma and fibrolamellar hepatocellular carcinoma.JHEP Rep202642595050PubTator, text miningPubMed
Hepatoprotective evaluation of benzoylated emodin derivatives: Integrating bioinformatics and in vitro studies.Biomedicine (Taipei)202642555442PubTator, text miningPubMed

1 to 10 of 2,763

See all 2,763 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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