Gene · 5566
PRKACA: protein kinase cAMP-activated catalytic subunit alpha
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. PRKACA: protein kinase cAMP-activated catalytic subunit alpha. Genes, record 5566. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5566
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P17612 | cAMP-dependent protein kinase catalytic subunit alpha | 351 | 54 | Ensembl, GeneID, HGNC |
Source UniProt
Patents73
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026082831 A | 2026-05-19 | 1 | P17612 | Espacenet |
| EP 4694917 A1 | 2026-02-18 | 637 | P17612 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 59765 | P17612 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 59767 | P17612 | Espacenet |
| WO 2025252547 A1 | 2025-12-11 | 111 | P17612 | Espacenet |
| EP 4660322 A1 | 2025-12-10 | 111 | P17612 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 4635 | P17612 | Espacenet |
| US 12473332 B2 | 2025-11-18 | 1 | P17612 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 4635 | P17612 | Espacenet |
| WO 2025016918 A1 | 2025-01-23 | 111 | P17612 | Espacenet |
1 to 10 of 73
See all 73 patentsDrugs1
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action |
|---|---|---|---|
| GSK-690693 | CHEMBL494089 | cAMP-dependent protein kinase (PKA) inhibitor | INHIBITOR |
Source ChEMBL
Trials2
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT00666081 | GSK-690693 | PHASE1 | ClinicalTrials.gov | |
| NCT00493818 | GSK-690693 | PHASE1 | ClinicalTrials.gov |
NIH grants1,878
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | PRKACA papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 23 | 2025 |
| P50CA210964 | Mayo Clinic Hepatobiliary SPORE | 17 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 16 | 2025 |
| UL1TR001866 | Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational Success | 12 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 6 | 2025 |
| R01DK119192 | Defective PKA Signaling in Cushing's Syndrome | 6 | 2025 |
| R35GM130389 | Lessons Learned from PKA: Assembly of Dynamic Macromolecular Switches | 6 | 2025 |
| U54GM115428 | Mississippi Center for Clinical and Translational Research | 5 | 2025 |
| P30CA015083 | Mayo Clinic Comprehensive Cancer Center Support Grant | 4 | 2025 |
| P30CA046592 | University of Michigan Rogel Cancer Center Support Grant 2023-2028 | 4 | 2025 |
1 to 10 of 1,878Source NIH's project files
See all 1,878 nih grantsPapers2,763
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Screening of Programmed Cell Death-Related Biomarkers and Exploration of Mechanisms in Zhenwu Decoction for Treating Chronic Kidney Disease. | Comb Chem High Throughput Screen | 2026 | 42817110 | PubTator, text mining | PubMed |
| Quercetin, an active component of Qiu's HuaShi decoction, suppresses glycolysis in cervical epithelial cells to reduce HPV infection via modulating the PRKACA/cAMP/PKA/CREB pathway. | Biochim Biophys Acta Gen Subj | 2026 | 42805466 | PubTator, text mining | PubMed |
| A parsimonious three-gene mitochondrial classifier from frontal cortex for Alzheimer's disease: Nested cross-validation and multicenter external validation. | J Alzheimers Dis | 2026 | 42742534 | PubTator, text mining | PubMed |
| Exploring the therapeutic potential of Astragalin in Parkinson's disease: a network pharmacology approach. | Ann Med Surg (Lond) | 2026 | 42724825 | PubTator, text mining | PubMed |
| Association between HOMA-IR and coexisting MASLD and type 2 diabetes: Insights from NHANES and network pharmacology. | Ther Adv Endocrinol Metab | 2026 | 42719461 | PubTator, text mining | PubMed |
| [Fibrolamellar hepatocellular carcinoma: a clinicopathological and molecular genetic analysis of nine cases]. | Zhonghua Bing Li Xue Za Zhi | 2026 | 42706111 | PubTator, text mining | PubMed |
| The identification of a PRKACA duplication at 19p13.12 in a female with PPNAD and thyroid carcinoma after a 20-year diagnostic journey. | Fam Cancer | 2026 | 42667476 | PubTator, text mining | PubMed |
| Deciphering the Molecular Basis: Integrative Multi-Method Analysis of Bioactive Constituents and Their Anti-Lung Cancer Mechanisms in Clinical Traditional Chinese Medicine Formulations. | Chem Biodivers | 2026 | 42607109 | PubTator, text mining | PubMed |
| Management of rare primary liver cancers: combined hepato-cholangiocarcinoma and fibrolamellar hepatocellular carcinoma. | JHEP Rep | 2026 | 42595050 | PubTator, text mining | PubMed |
| Hepatoprotective evaluation of benzoylated emodin derivatives: Integrating bioinformatics and in vitro studies. | Biomedicine (Taipei) | 2026 | 42555442 | PubTator, text mining | PubMed |
1 to 10 of 2,763
See all 2,763 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/5566
GET https://conductscience.org/api/genes/v1/5566/patents?page=2