Gene · 5600
MAPK11: mitogen-activated protein kinase 11
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. MAPK11: mitogen-activated protein kinase 11. Genes, record 5600. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5600
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q15759 | Mitogen-activated protein kinase 11 | 364 | 4 | Ensembl, GeneID, HGNC |
Source UniProt
Patents65
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| US 12539325 B2 | 2026-02-03 | 49 | Q15759 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 6039 | Q15759 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 6039 | Q15759 | Espacenet |
| US 12252709 B2 | 2025-03-18 | 25 | Q15759 | Espacenet |
| US 12133879 B2 | 2024-11-05 | 49 | Q15759 | Espacenet |
| JP 2024123008 A | 2024-09-10 | 7031 | Q15759 | Espacenet |
| JP 2024123008 A | 2024-09-10 | 7032 | Q15759 | Espacenet |
| US 11920164 B2 | 2024-03-05 | 43 | Q15759 | Espacenet |
| JP 2024012295 A | 2024-01-30 | 3 | Q15759 | Espacenet |
| US 11872193 B2 | 2024-01-16 | 49 | Q15759 | Espacenet |
1 to 10 of 65
See all 65 patentsDrugs3
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
Trials268
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07559864 | REGORAFENIB | PHASE2 | ClinicalTrials.gov | |
| NCT07537985 | REGORAFENIB | ClinicalTrials.gov | ||
| NCT07514455 | REGORAFENIB | PHASE2 | ClinicalTrials.gov | |
| NCT07514429 | REGORAFENIB | PHASE2 | ClinicalTrials.gov | |
| NCT07501351 | REGORAFENIB | PHASE2 | ClinicalTrials.gov | |
| NCT07495579 | REGORAFENIB | PHASE2 | ClinicalTrials.gov | |
| NCT07463248 | REGORAFENIB | PHASE2 | ClinicalTrials.gov | |
| NCT07379047 | REGORAFENIB | PHASE2/PHASE3 | ClinicalTrials.gov | |
| NCT07343791 | REGORAFENIB | EARLY_PHASE1 | ClinicalTrials.gov | |
| NCT07328009 | REGORAFENIB | PHASE2 | ClinicalTrials.gov |
1 to 10 of 268
See all 268 trialsNIH grants1,197
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | MAPK11 papers | Newest fiscal year |
|---|---|---|---|
| P30CA016672 | Cancer Center Support Grant | 9 | 2025 |
| P30CA033572 | Cancer Center Support Grant | 4 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 4 | 2025 |
| R01AA015407 | Endoplasmic Reticulum Stress and Alcohol Neurotoxicity | 4 | 2025 |
| P30CA125123 | Baylor College of Medicine Cancer Center - Cancer Center Support Grant | 3 | 2025 |
| P30CA177558 | University of Kentucky Markey Cancer Center – Cancer Center Support Grant | 3 | 2025 |
| R01HL070562 | Actions of Estrogen on Uterine Artery Endothelium | 3 | 2025 |
| P20GM103466 | HAWAII INBRE V PROGRAM | 2 | 2025 |
| P30AG028740 | University of Florida Older Americans Independence Center (OAIC) | 2 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 2 | 2025 |
1 to 10 of 1,197Source NIH's project files
See all 1,197 nih grantsPapers1,936
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| p38β-mediated BiP phosphorylation drives stemness and chemoresistance by suppressing UPR activation in hepatocellular carcinoma. | Nat Commun | 2026 | 42686683 | PubTator, text mining | PubMed |
| Retraction: Inhibition of SAPK2/p38 Enhances Sensitivity to mTORC1 Inhibition by Blocking IRES-Mediated Translation Initiation in Glioblastoma. | Mol Cancer Ther | 2026 | 42548212 | PubTator, text mining | PubMed |
| HIPK2 exhibits context dependent dualistic effects and combinatorial inhibition of HIPK2-NLK-MAPK11 axis manifests synergism against gastric cancer. | Hum Cell | 2026 | 42547687 | PubTator, text mining | PubMed |
| Hepatic stellate cell enriched Asporin drives liver fibrosis by stabilizing ERH to promote IL-17/MAPK11 signaling. | Acta Pharm Sin B | 2026 | 42453400 | PubTator, text mining | PubMed |
| Discrete On-DNA Screening: A Frontier for Rapid Hit-to-Lead Optimization Applied to p38α. | ACS Med Chem Lett | 2026 | 42445005 | PubTator, text mining | PubMed |
| The oral-gut-joint axis in osteoarthritis: a multiomics case-control study. | Front Cell Infect Microbiol | 2026 | 42440607 | PubTator, text mining | PubMed |
| α-Viniferin Induces Intrinsic Apoptosis in Triple-Negative Breast Cancer Cells and Synergizes With SB203580 Independently of p38 Mitogen-Activated Protein Kinase. | J Breast Cancer | 2026 | 42237516 | PubTator, text mining | PubMed |
| Phosphoproteomic and kinase networks reveal partial EMT and stress-adaptive growth programs in pediatric Peutz-Jeghers polyps. | Pediatr Res | 2026 | 42082734 | PubTator, text mining | PubMed |
| Integrated Genomic and Transcriptomic Study Reveals MAPK11 and PER1 as Important Obesity Susceptibility Genes in a High-Risk Hispanic/Latino Population. | Circ Genom Precis Med | 2026 | 42037308 | PubTator, text mining | PubMed |
| Integrative Mendelian randomization and experimental validation prioritize KLF4 in the gut microbiota-pyroptosis-barrier axis of ulcerative colitis. | Front Immunol | 2026 | 41918723 | PubTator, text mining | PubMed |
1 to 10 of 1,936
See all 1,936 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/5600
GET https://conductscience.org/api/genes/v1/5600/patents?page=2