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Gene · 5600

MAPK11: mitogen-activated protein kinase 11

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. MAPK11: mitogen-activated protein kinase 11. Genes, record 5600. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5600

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Gene

Symbol
MAPK11
HGNC
Name
mitogen-activated protein kinase 11
HGNC
NCBI Gene ID
5600
NCBI Gene
HGNC ID
HGNC:6873
HGNC
Ensembl
ENSG00000185386
NCBI Gene
Aliases
P38B, P38BETA2, PRKM11, SAPK2, SAPK2B, p38-2, p38Beta
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q15759Mitogen-activated protein kinase 113644Ensembl, GeneID, HGNC

Source UniProt

Patents65

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
US 12539325 B22026-02-0349Q15759Espacenet
EP 4650780 A22025-11-196039Q15759Espacenet
JP 2025517970 A2025-06-126039Q15759Espacenet
US 12252709 B22025-03-1825Q15759Espacenet
US 12133879 B22024-11-0549Q15759Espacenet
JP 2024123008 A2024-09-107031Q15759Espacenet
JP 2024123008 A2024-09-107032Q15759Espacenet
US 11920164 B22024-03-0543Q15759Espacenet
JP 2024012295 A2024-01-303Q15759Espacenet
US 11872193 B22024-01-1649Q15759Espacenet

1 to 10 of 65

See all 65 patents

Drugs3

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
LOSMAPIMODCHEMBL1088752MAP kinase p38 beta inhibitorINHIBITORChEMBL
REGORAFENIBCHEMBL1946170MAP kinase p38 beta inhibitorINHIBITORChEMBL
RWJ-67657CHEMBL190333MAP kinase p38 beta inhibitorINHIBITORChEMBL

Trials268

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07559864REGORAFENIBPHASE2ClinicalTrials.gov
NCT07537985REGORAFENIBClinicalTrials.gov
NCT07514455REGORAFENIBPHASE2ClinicalTrials.gov
NCT07514429REGORAFENIBPHASE2ClinicalTrials.gov
NCT07501351REGORAFENIBPHASE2ClinicalTrials.gov
NCT07495579REGORAFENIBPHASE2ClinicalTrials.gov
NCT07463248REGORAFENIBPHASE2ClinicalTrials.gov
NCT07379047REGORAFENIBPHASE2/PHASE3ClinicalTrials.gov
NCT07343791REGORAFENIBEARLY_PHASE1ClinicalTrials.gov
NCT07328009REGORAFENIBPHASE2ClinicalTrials.gov

1 to 10 of 268

See all 268 trials

NIH grants1,197

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleMAPK11 papersNewest fiscal year
P30CA016672Cancer Center Support Grant92025
P30CA033572Cancer Center Support Grant42025
P30CA068485Cancer Center Support Grant42025
R01AA015407Endoplasmic Reticulum Stress and Alcohol Neurotoxicity42025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant32025
P30CA177558University of Kentucky Markey Cancer Center – Cancer Center Support Grant32025
R01HL070562Actions of Estrogen on Uterine Artery Endothelium32025
P20GM103466HAWAII INBRE V PROGRAM22025
P30AG028740University of Florida Older Americans Independence Center (OAIC)22025
P30CA008748Cancer Center Support Grant22025

1 to 10 of 1,197Source NIH's project files

See all 1,197 nih grants

Papers1,936

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
p38β-mediated BiP phosphorylation drives stemness and chemoresistance by suppressing UPR activation in hepatocellular carcinoma.Nat Commun202642686683PubTator, text miningPubMed
Retraction: Inhibition of SAPK2/p38 Enhances Sensitivity to mTORC1 Inhibition by Blocking IRES-Mediated Translation Initiation in Glioblastoma.Mol Cancer Ther202642548212PubTator, text miningPubMed
HIPK2 exhibits context dependent dualistic effects and combinatorial inhibition of HIPK2-NLK-MAPK11 axis manifests synergism against gastric cancer.Hum Cell202642547687PubTator, text miningPubMed
Hepatic stellate cell enriched Asporin drives liver fibrosis by stabilizing ERH to promote IL-17/MAPK11 signaling.Acta Pharm Sin B202642453400PubTator, text miningPubMed
Discrete On-DNA Screening: A Frontier for Rapid Hit-to-Lead Optimization Applied to p38α.ACS Med Chem Lett202642445005PubTator, text miningPubMed
The oral-gut-joint axis in osteoarthritis: a multiomics case-control study.Front Cell Infect Microbiol202642440607PubTator, text miningPubMed
α-Viniferin Induces Intrinsic Apoptosis in Triple-Negative Breast Cancer Cells and Synergizes With SB203580 Independently of p38 Mitogen-Activated Protein Kinase.J Breast Cancer202642237516PubTator, text miningPubMed
Phosphoproteomic and kinase networks reveal partial EMT and stress-adaptive growth programs in pediatric Peutz-Jeghers polyps.Pediatr Res202642082734PubTator, text miningPubMed
Integrated Genomic and Transcriptomic Study Reveals MAPK11 and PER1 as Important Obesity Susceptibility Genes in a High-Risk Hispanic/Latino Population.Circ Genom Precis Med202642037308PubTator, text miningPubMed
Integrative Mendelian randomization and experimental validation prioritize KLF4 in the gut microbiota-pyroptosis-barrier axis of ulcerative colitis.Front Immunol202641918723PubTator, text miningPubMed

1 to 10 of 1,936

See all 1,936 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5600

GET https://conductscience.org/api/genes/v1/5600/patents?page=2