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Gene · 5627

PROS1: protein S

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PROS1: protein S. Genes, record 5627. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5627

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Gene

Symbol
PROS1
HGNC
Name
protein S
HGNC
NCBI Gene ID
5627
NCBI Gene
HGNC ID
HGNC:9456
HGNC
Ensembl
ENSG00000184500
NCBI Gene
Aliases
PROS, PS21, PS22, PS23, PS24, PS25, PSA, THPH5, THPH6
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P07225Vitamin K-dependent protein S6763Ensembl, GeneID, HGNC

Source UniProt

Patents65

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026515744 A2026-05-1980P07225Espacenet
WO 2026094971 A2026-05-071P07225Espacenet
JP 2026004568 A2026-01-1460042P07225Espacenet
WO 2025240928 A12025-11-201P07225Espacenet
EP 4650780 A22025-11-195835P07225Espacenet
EP 4641201 A22025-10-295547P07225Espacenet
JP 2025147176 A2025-10-0610858P07225Espacenet
US 12421320 B22025-09-23216P07225Espacenet
JP 2025529142 A2025-09-043585P07225Espacenet
JP 2025529142 A2025-09-047441P07225Espacenet

1 to 10 of 65

See all 65 patents

Drugs2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
PROTEIN S HUMANCHEMBL6068491Vitamin K-dependent protein S exogenous proteinEXOGENOUS PROTEINChEMBL
PROTHROMBIN COMPLEX CONCENTRATECHEMBL6068614Vitamin K-dependent protein S exogenous proteinEXOGENOUS PROTEINChEMBL

Trials13

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07094087PROTHROMBIN COMPLEX CONCENTRATEPHASE3ClinicalTrials.gov
NCT05568888PROTHROMBIN COMPLEX CONCENTRATEPHASE32025-11-10ClinicalTrials.gov
NCT05523297PROTHROMBIN COMPLEX CONCENTRATEPHASE32025-08-15ClinicalTrials.gov
NCT04114643PROTHROMBIN COMPLEX CONCENTRATEPHASE2ClinicalTrials.gov
NCT03784794PROTHROMBIN COMPLEX CONCENTRATEClinicalTrials.gov
NCT03715348PROTHROMBIN COMPLEX CONCENTRATEPHASE2ClinicalTrials.gov
NCT03341156PROTHROMBIN COMPLEX CONCENTRATEPHASE3ClinicalTrials.gov
NCT02429453PROTHROMBIN COMPLEX CONCENTRATEClinicalTrials.gov
NCT02270918PROTHROMBIN COMPLEX CONCENTRATEPHASE1ClinicalTrials.gov
NCT01779921PROTHROMBIN COMPLEX CONCENTRATEClinicalTrials.gov

1 to 10 of 13

See all 13 trials

NIH grants989

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePROS1 papersNewest fiscal year
P30CA008748Cancer Center Support Grant62025
UL1TR001863Yale Clinical and Translational Science Award62025
P30CA046934University of Colorado Cancer Center Support Grant52025
P30CA016359Cancer Center Support Grant42025
P30CA016672Cancer Center Support Grant42025
T32GM008315Mechanisms of Trauma-Induced Coagulopathy42025
P01CA163205Circumventing Barriers to Effective Oncolytic Virotherapy of Malignant Gliomas32025
P30CA014195Cancer Center Support Grant (CCSG)32025
R01HL121718Structural and Functional Basis of the Vitamin K Cycle32025
K12CA086913Paul Calabresi Award in Clinical Oncology Research22025

1 to 10 of 989Source NIH's project files

See all 989 nih grants

Papers1,864

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Lactylation-Driven PROS1-TYRO3-CARF Signaling Promotes Therapy-Induced Senescence Escape and Radioresistance in Meningioma.Adv Sci (Weinh)202642750190PubTator, text miningPubMed
Complement expression profiles in human glomerular mesangial cells, endothelial cells, podocytes and proximal tubular epithelial cells.Front Immunol202642746023PubTator, text miningPubMed
Expression of TAM receptors and their ligands in unexplained recurrent pregnancy loss.Immunol Res202642684543PubTator, text miningPubMed
Expression of PROS1 in Negative Pressure Treatment of Diabetic Foot Ulcers and its Effect on Angiogenesis.Arch Med Res202642612604PubTator, text miningPubMed
DIA-based serum proteomics of the complement-coagulation cascade identifies candidate biomarkers for myasthenia gravis.Front Neurosci202642516550PubTator, text miningPubMed
An Exploratory Pilot Study of Coagulation- and Fibrinolysis-Related Proteins in Unexplained Infertility.Int J Mol Sci202642450115PubTator, text miningPubMed
Protein S: a vitamin K-dependent factor bridging haemostasis, tissue homeostasis and cancer.Biochem J202642429079PubTator, text miningPubMed
Pedigree analysis of cerebral venous sinus thrombosis associated with compound heterozygous hereditary protein S deficiency.Ann Hematol202642406071PubTator, text miningPubMed
Cerebral venous sinus thrombosis in a family with protein S deficiency: genetic analysis and phenotypic characterization.Thromb J202642343414PubTator, text miningPubMed
CTSK+ macrophages drive fibrotic stenosis in benign airway stenosis via the PROS1-AXL pathway.Int Immunopharmacol202642302376PubTator, text miningPubMed

1 to 10 of 1,864

See all 1,864 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5627

GET https://conductscience.org/api/genes/v1/5627/patents?page=2