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Gene · 56479

KCNQ5: potassium voltage-gated channel subfamily Q member 5

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. KCNQ5: potassium voltage-gated channel subfamily Q member 5. Genes, record 56479. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/56479

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Gene

Symbol
KCNQ5
HGNC
Name
potassium voltage-gated channel subfamily Q member 5
HGNC
NCBI Gene ID
56479
NCBI Gene
HGNC ID
HGNC:6299
HGNC
Ensembl
ENSG00000185760
NCBI Gene
Aliases
Kv7.5, MRD46
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9NR82Potassium voltage-gated channel subfamily KQT member 59325Ensembl, GeneID, HGNC

Source UniProt

Patents24

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1458749Q9NR82Espacenet
EP 4641201 A22025-10-298971Q9NR82Espacenet
JP 2025529142 A2025-09-042263Q9NR82Espacenet
US 12371689 B22025-07-292263Q9NR82Espacenet
JP 2025517969 A2025-06-128971Q9NR82Espacenet
JP 2025032204 A2025-03-1130455Q9NR82Espacenet
EP 4461818 A22024-11-1330455Q9NR82Espacenet
JP 2023058610 A2023-04-2530455Q9NR82Espacenet
US 11446398 B22022-09-2065804Q9NR82Espacenet
JP 2022524081 A2022-04-27168775Q9NR82Espacenet

1 to 10 of 24

See all 24 patents

Drugs9

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AMIFAMPRIDINECHEMBL354077Voltage-gated potassium channel blockerBLOCKERChEMBL
AMIFAMPRIDINE PHOSPHATECHEMBL3301611Voltage-gated potassium channel blockerBLOCKERChEMBL
DALFAMPRIDINECHEMBL284348Voltage-gated potassium channel blockerBLOCKERChEMBL
EZOGABINECHEMBL41355KCNQ (Kv7) potassium channel openerOPENERChEMBL
FLINDOKALNERCHEMBL266510Voltage-gated potassium channel subunit Kv7.5 activatorACTIVATORChEMBL
GUANIDINECHEMBL821Voltage-gated potassium channel blockerBLOCKERChEMBL
GUANIDINE HYDROCHLORIDECHEMBL1200728Voltage-gated potassium channel blockerBLOCKERChEMBL
NERISPIRDINECHEMBL2107762Voltage-gated potassium channel blockerBLOCKERChEMBL
TEDISAMILCHEMBL113461Voltage-gated potassium channel blockerBLOCKERChEMBL

Trials96

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07532460DALFAMPRIDINEClinicalTrials.gov
NCT07185347DALFAMPRIDINEPHASE3ClinicalTrials.gov
NCT07171203DALFAMPRIDINEPHASE1ClinicalTrials.gov
NCT06853015DALFAMPRIDINEPHASE1/PHASE2ClinicalTrials.gov
NCT06751784DALFAMPRIDINEPHASE2ClinicalTrials.gov
NCT06596434DALFAMPRIDINEPHASE2ClinicalTrials.gov
NCT06333171DALFAMPRIDINEPHASE2ClinicalTrials.gov
NCT06294821DALFAMPRIDINEPHASE2ClinicalTrials.gov
NCT06136728DALFAMPRIDINEPHASE3ClinicalTrials.gov
NCT05919407AMIFAMPRIDINEPHASE3ClinicalTrials.gov

1 to 10 of 96

See all 96 trials

NIH grants669

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleKCNQ5 papersNewest fiscal year
R35GM130377Ion Channel Transporter Interactions112025
R01NS107671Therapeutic small molecule modulation of Kv channels82025
UL1TR001863Yale Clinical and Translational Science Award52025
R01HL137094Role of KCNQ2 Channels in Control of Breathing42025
P50AA010761Alcohol Research Center - Treatment and Implications32025
R01HL122010Decrypting Variants of Uncertain Significance in Long-QT Syndrome32025
P30CA034196Cancer Center Support (CORE) Grant22025
P30DK040561Boston Area Nutrition Obesity Research Center (NORC)22025
R01DC007664Structural Studies of Ion Channel Assembly and Signaling Complexes22025
R01DK107859Genetics of chronotype and impact on metabolic disease22025

1 to 10 of 669Source NIH's project files

See all 669 nih grants

Papers763

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Kv7 channels as pharmacological targets for central nervous system diseases.Pharmacol Rev202642772203PubTator, text miningPubMed
Genome-wide association study of vitamin D status in diverse ancestry individuals with adjustment for ambient ultraviolet B (UVB) radiation.Clin Nutr202642570365PubTator, text miningPubMed
CRISPR/Cas9-mediated PHOX2B functional knock-out in IMR32 neuroblastoma cells impairs neuronal excitability through dysregulation of ion channels genes.Front Physiol202642422362PubTator, text miningPubMed
Functional screen for subtype specificity of voltage sensor-targeted Kv7 potentiators.Br J Pharmacol202642271185PubTator, text miningPubMed
Potassium Channelopathies and Precision Medicine Approaches in Epilepsy: A Systematic Review of Personalized Treatment Strategies.Curr Neuropharmacol202642003125PubTator, text miningPubMed
Extensive genetic interactions (epistasis) linked to alcohol use disorder in a high-risk population.Commun Biol202641942605PubTator, text miningPubMed
Snapshot on Cell-to-Cell Communication Nanotubes: From Bacteria to Humans.Biology (Basel)202641892274PubTator, text miningPubMed
M2 muscarinic receptor-dependent contractions of airway smooth muscle are mediated by inhibition of Kv7 channels.Am J Physiol Cell Physiol202641784087PubTator, text miningPubMed
Inflammatory mechanisms underlying early Alzheimer's disease pathology: evidence from the aging rhesus macaque brain.Front Cell Neurosci202641767744PubTator, text miningPubMed
Discovery and Evaluation of E0714 as an Antiepileptic Candidate: A Highly Subtype-Selective Kv7 Agonist within the Kv7 Family Designed Based on a Kv7.2-Specific Pocket.J Med Chem202641711326PubTator, text miningPubMed

1 to 10 of 763

See all 763 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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