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Gene · 5739

PTGIR: prostaglandin I2 receptor

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PTGIR: prostaglandin I2 receptor. Genes, record 5739. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5739

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Gene

Symbol
PTGIR
HGNC
Name
prostaglandin I2 receptor
HGNC
NCBI Gene ID
5739
NCBI Gene
HGNC ID
HGNC:9602
HGNC
Ensembl
ENSG00000160013
NCBI Gene
Aliases
IP, PRIPR
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P43119Prostacyclin receptor3862Ensembl, GeneID, HGNC

Source UniProt

Patents52

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1459423P43119Espacenet
JP 2025172069 A2025-11-20443P43119Espacenet
EP 4650780 A22025-11-193455P43119Espacenet
EP 4641201 A22025-10-293042P43119Espacenet
JP 2025147176 A2025-10-0611045P43119Espacenet
JP 2025529142 A2025-09-043626P43119Espacenet
JP 2025529142 A2025-09-047487P43119Espacenet
US 12371689 B22025-07-293626P43119Espacenet
US 12371689 B22025-07-297487P43119Espacenet
JP 2025517969 A2025-06-123042P43119Espacenet

1 to 10 of 52

See all 52 patents

Drugs10

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
EPOPROSTENOLCHEMBL1139Prostanoid IP receptor agonistAGONISTChEMBL
EPOPROSTENOL SODIUMCHEMBL962Prostanoid IP receptor agonistAGONISTChEMBL
ESUBERAPROSTCHEMBL3137314Prostanoid IP receptor agonistAGONISTChEMBL
ILOPROSTCHEMBL494Prostanoid IP receptor agonistAGONISTChEMBL
ILOPROST TROMETHAMINECHEMBL5315118Prostanoid IP receptor agonistAGONISTChEMBL
RALINEPAGCHEMBL3301604Prostanoid IP receptor agonistAGONISTChEMBL
SELEXIPAGCHEMBL238804Prostanoid IP receptor agonistAGONISTChEMBL
TREPROSTINILCHEMBL1237119Prostanoid IP receptor agonistAGONISTChEMBL
TREPROSTINIL DIOLAMINECHEMBL2107815Prostanoid IP receptor agonistAGONISTChEMBL
TREPROSTINIL SODIUMCHEMBL561157Prostanoid IP receptor agonistAGONISTChEMBL

Trials197

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

NIH grants584

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePTGIR papersNewest fiscal year
R01HL092961Epithelial-Mesenchymal Interactions in Fibrosis Resolution32025
U19AI070535Airway Inflammation and Airway Remodeling in Severe Asthma32025
U19AI095227Viral and Host Determinants of Infant and Childhood Allergy and Asthma32025
P30CA046934University of Colorado Cancer Center Support Grant22025
P30CA068485Cancer Center Support Grant22025
P30DK058404Molecular and Cellular Basis for Digestive Diseases22025
R01HL077612Precision phenotyping of emphysema in the elderly: the MESA Lung Study22025
R01HL111656Vascular Targeting Genomic & Genetic Strategies for Acute Chest Syndrome22025
T32HL007284Basic Cardiovascular Research Training Grant22025
T32HL007853Multidisciplinary Cardiovascular Research Training22025

1 to 10 of 584Source NIH's project files

See all 584 nih grants

Papers1,202

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Real-world analysis on hemodynamic effectiveness and adverse events of selexipag in pulmonary arterial hypertension.Ther Adv Respir Dis202642808704PubTator, text miningPubMed
Indirect Treatment Comparison of Riociguat Replacement Therapy and Selexipag Add-on Therapy in Patients With Pulmonary Arterial Hypertension: Results From a Systematic Review.Rev Cardiovasc Med202642238623PubTator, text miningPubMed
Experience with selexipag in triple therapy for pulmonary arterial hypertension in Chinese children.BMC Pediatr202642104335PubTator, text miningPubMed
Prostaglandin I2 receptor activation promotes alveolar regeneration via the JUN/p53 pathway.Am J Respir Crit Care Med202642085259PubTator, text miningPubMed
Practical Considerations for Managing Transitions from Parenteral Prostacyclins to Oral Selexipag in Pulmonary Arterial Hypertension.Pulm Ther202641952024PubTator, text miningPubMed
Future Prospects of Imatinib in Advanced Pulmonary Hypertension Management.IUBMB Life202641885124PubTator, text miningPubMed
PAH-former: Transfer learning for efficient discovery of pulmonary arterial hypertension-associated genes.PLoS One202641790620PubTator, text miningPubMed
Regulatory roles of bioactive lipids in vascular homeostasis and remodeling.Med Rev (2021)202641783891PubTator, text miningPubMed
Development of immune-derived molecular markers for coronary heart disease via multimachine learning.iScience202641782820PubTator, text miningPubMed
The Pathophysiology, Mechanism, Diagnosis, and Management of Pulmonary Arterial Hypertension: A Comprehensive Literature Review.US Cardiol202641766785PubTator, text miningPubMed

1 to 10 of 1,202

See all 1,202 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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