Gene · 5745
PTH1R: parathyroid hormone 1 receptor
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. PTH1R: parathyroid hormone 1 receptor. Genes, record 5745. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5745
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q03431 | Parathyroid hormone/parathyroid hormone-related peptide receptor | 593 | 48 | Ensembl, GeneID, HGNC |
Source UniProt
Patents58
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4650780 A2 | 2025-11-19 | 5408 | Q03431 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 5013 | Q03431 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 3628 | Q03431 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 3628 | Q03431 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 5013 | Q03431 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 5408 | Q03431 | Espacenet |
| US 11878063 B2 | 2024-01-23 | 76 | Q03431 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 61273 | Q03431 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 61277 | Q03431 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 61278 | Q03431 | Espacenet |
1 to 10 of 58
See all 58 patentsDrugs6
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| ABALOPARATIDE | CHEMBL3301581 | Parathyroid hormone receptor agonist | AGONIST | ChEMBL |
| OSTABOLIN-C | CHEMBL4802222 | Parathyroid hormone receptor agonist | AGONIST | ChEMBL |
| PALOPEGTERIPARATIDE | CHEMBL5095475 | Parathyroid hormone receptor agonist | AGONIST | ChEMBL |
| PARATHYROID HORMONE | CHEMBL2108078 | Parathyroid hormone receptor agonist | AGONIST | ChEMBL |
| TERIPARATIDE | CHEMBL525610 | Parathyroid hormone receptor agonist | AGONIST | ChEMBL |
| TERIPARATIDE ACETATE | CHEMBL1201549 | Parathyroid hormone receptor agonist | AGONIST | ChEMBL |
Trials162
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07587775 | ABALOPARATIDE | PHASE2 | ClinicalTrials.gov | |
| NCT07530705 | PARATHYROID HORMONE | PHASE1/PHASE2 | ClinicalTrials.gov | |
| NCT07530705 | PALOPEGTERIPARATIDE | PHASE1/PHASE2 | ClinicalTrials.gov | |
| NCT07242612 | TERIPARATIDE | ClinicalTrials.gov | ||
| NCT07233850 | TERIPARATIDE | PHASE2 | ClinicalTrials.gov | |
| NCT07081997 | PALOPEGTERIPARATIDE | PHASE3 | ClinicalTrials.gov | |
| NCT07028320 | TERIPARATIDE | PHASE3 | ClinicalTrials.gov | |
| NCT06898060 | ABALOPARATIDE | PHASE3 | ClinicalTrials.gov | |
| NCT06898060 | TERIPARATIDE | PHASE3 | ClinicalTrials.gov | |
| NCT06558188 | TERIPARATIDE | PHASE4 | ClinicalTrials.gov |
1 to 10 of 162
See all 162 trialsNIH grants1,470
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | PTH1R papers | Newest fiscal year |
|---|---|---|---|
| R01DK116780 | Structure and function of PTH class B GPCR | 13 | 2025 |
| R01DK113039 | PTH Inverse Agonists as Therapy for Jansens Disease | 10 | 2025 |
| R01DK047420 | Nuclear Events in PTHR1 Action on Bone | 7 | 2025 |
| ZIADE000649 | Skeletal Disorders and Mineral Homeostasis Section | 6 | 2025 |
| R01HL016037 | Molecular Regulation of Cardiovascular 7 TM Receptors | 5 | 2025 |
| UL1TR001863 | Yale Clinical and Translational Science Award | 5 | 2025 |
| P20GM103408 | Idaho INBRE Program | 4 | 2025 |
| P30AR075042 | Center for Musculoskeletal Research | 4 | 2025 |
| R01AR053237 | Lrp5 and Lrp6 signaling in bone mechanotransduction and metabolism | 4 | 2025 |
| R01DA012864 | Mechanisms and Cellular Function of Opioid Receptor Endocytosis | 4 | 2025 |
1 to 10 of 1,470Source NIH's project files
See all 1,470 nih grantsPapers2,698
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Discovery and characterization of potent and efficacious small-molecule parathyroid hormone Receptor-1 (PTH1R) antagonists for the treatment of hypercalcemia. | Bioorg Med Chem Lett | 2027 | 42822604 | PubTator, text mining | PubMed |
| Eiken syndrome presenting as pseudohypoparathyroidism due to PTH1R gene pathogenic variant. | JCEM Case Rep | 2026 | 42824313 | PubTator, text mining | PubMed |
Statement of Retraction: Convallatoxin suppresses osteosarcoma cell proliferation, migration, invasion, and enhances osteogenic differentiation by downregulating parathyroid hormone receptor 1 (PTHR1) expression and inactivating Wnt/β-catenin pathway. | Bioengineered | 2026 | 42821801 | PubTator, text mining | PubMed |
| A novel PTH1R missense variant in a patient with early-onset primary hyperparathyroidism. | Bone Rep | 2026 | 42751087 | PubTator, text mining | PubMed |
| Spatial control of parathyroid hormone receptor-1 signaling dictates ligand-specific biological outcomes. | Signal Transduct Target Ther | 2026 | 42722652 | PubTator, text mining | PubMed |
| Structural basis of β-arrestin coupling and transducer selectivity in PAC1R. | Acta Pharmacol Sin | 2026 | 42706324 | PubTator, text mining | PubMed |
| Adynamic Bone Disease in Chronic Kidney Disease: From Parathyroid Hormone Suppression-Driven Remodeling Phenotype to Osteoanabolic Therapy. | Am J Nephrol | 2026 | 42671953 | PubTator, text mining | PubMed |
| Association of EBV EBNA1 C-terminal variations with severity of Invasive ductal carcinoma. | Mol Biol Rep | 2026 | 42667440 | PubTator, text mining | PubMed |
| De-Nterm-ining GLP1R signaling bias. | Trends Pharmacol Sci | 2026 | 42660721 | PubTator, text mining | PubMed |
| Skeletal dysplasias of the parathyroid hormone signaling cascade: radiological manifestations and molecular mechanisms. | Pediatr Radiol | 2026 | 42631736 | PubTator, text mining | PubMed |
1 to 10 of 2,698
See all 2,698 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/5745
GET https://conductscience.org/api/genes/v1/5745/patents?page=2