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Gene · 5745

PTH1R: parathyroid hormone 1 receptor

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PTH1R: parathyroid hormone 1 receptor. Genes, record 5745. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5745

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Gene

Symbol
PTH1R
HGNC
Name
parathyroid hormone 1 receptor
HGNC
NCBI Gene ID
5745
NCBI Gene
HGNC ID
HGNC:9608
HGNC
Ensembl
ENSG00000160801
NCBI Gene
Aliases
EKNS, PFE, PTHR, PTHR1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q03431Parathyroid hormone/parathyroid hormone-related peptide receptor59348Ensembl, GeneID, HGNC

Source UniProt

Patents58

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-195408Q03431Espacenet
EP 4641201 A22025-10-295013Q03431Espacenet
JP 2025529142 A2025-09-043628Q03431Espacenet
US 12371689 B22025-07-293628Q03431Espacenet
JP 2025517969 A2025-06-125013Q03431Espacenet
JP 2025517970 A2025-06-125408Q03431Espacenet
US 11878063 B22024-01-2376Q03431Espacenet
US 11446398 B22022-09-2061273Q03431Espacenet
US 11446398 B22022-09-2061277Q03431Espacenet
US 11446398 B22022-09-2061278Q03431Espacenet

1 to 10 of 58

See all 58 patents

Drugs6

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ABALOPARATIDECHEMBL3301581Parathyroid hormone receptor agonistAGONISTChEMBL
OSTABOLIN-CCHEMBL4802222Parathyroid hormone receptor agonistAGONISTChEMBL
PALOPEGTERIPARATIDECHEMBL5095475Parathyroid hormone receptor agonistAGONISTChEMBL
PARATHYROID HORMONECHEMBL2108078Parathyroid hormone receptor agonistAGONISTChEMBL
TERIPARATIDECHEMBL525610Parathyroid hormone receptor agonistAGONISTChEMBL
TERIPARATIDE ACETATECHEMBL1201549Parathyroid hormone receptor agonistAGONISTChEMBL

Trials162

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07587775ABALOPARATIDEPHASE2ClinicalTrials.gov
NCT07530705PARATHYROID HORMONEPHASE1/PHASE2ClinicalTrials.gov
NCT07530705PALOPEGTERIPARATIDEPHASE1/PHASE2ClinicalTrials.gov
NCT07242612TERIPARATIDEClinicalTrials.gov
NCT07233850TERIPARATIDEPHASE2ClinicalTrials.gov
NCT07081997PALOPEGTERIPARATIDEPHASE3ClinicalTrials.gov
NCT07028320TERIPARATIDEPHASE3ClinicalTrials.gov
NCT06898060ABALOPARATIDEPHASE3ClinicalTrials.gov
NCT06898060TERIPARATIDEPHASE3ClinicalTrials.gov
NCT06558188TERIPARATIDEPHASE4ClinicalTrials.gov

1 to 10 of 162

See all 162 trials

NIH grants1,470

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePTH1R papersNewest fiscal year
R01DK116780Structure and function of PTH class B GPCR132025
R01DK113039PTH Inverse Agonists as Therapy for Jansens Disease102025
R01DK047420Nuclear Events in PTHR1 Action on Bone72025
ZIADE000649Skeletal Disorders and Mineral Homeostasis Section62025
R01HL016037Molecular Regulation of Cardiovascular 7 TM Receptors52025
UL1TR001863Yale Clinical and Translational Science Award52025
P20GM103408Idaho INBRE Program42025
P30AR075042Center for Musculoskeletal Research42025
R01AR053237Lrp5 and Lrp6 signaling in bone mechanotransduction and metabolism42025
R01DA012864Mechanisms and Cellular Function of Opioid Receptor Endocytosis42025

1 to 10 of 1,470Source NIH's project files

See all 1,470 nih grants

Papers2,698

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Discovery and characterization of potent and efficacious small-molecule parathyroid hormone Receptor-1 (PTH1R) antagonists for the treatment of hypercalcemia.Bioorg Med Chem Lett202742822604PubTator, text miningPubMed
Eiken syndrome presenting as pseudohypoparathyroidism due to PTH1R gene pathogenic variant.JCEM Case Rep202642824313PubTator, text miningPubMed
Statement of Retraction: Convallatoxin suppresses osteosarcoma cell proliferation, migration, invasion, and enhances osteogenic differentiation by downregulating parathyroid hormone receptor 1 (PTHR1) expression and inactivating Wnt/β-catenin pathway.
Bioengineered202642821801PubTator, text miningPubMed
A novel PTH1R missense variant in a patient with early-onset primary hyperparathyroidism.Bone Rep202642751087PubTator, text miningPubMed
Spatial control of parathyroid hormone receptor-1 signaling dictates ligand-specific biological outcomes.Signal Transduct Target Ther202642722652PubTator, text miningPubMed
Structural basis of β-arrestin coupling and transducer selectivity in PAC1R.Acta Pharmacol Sin202642706324PubTator, text miningPubMed
Adynamic Bone Disease in Chronic Kidney Disease: From Parathyroid Hormone Suppression-Driven Remodeling Phenotype to Osteoanabolic Therapy.Am J Nephrol202642671953PubTator, text miningPubMed
Association of EBV EBNA1 C-terminal variations with severity of Invasive ductal carcinoma.Mol Biol Rep202642667440PubTator, text miningPubMed
De-Nterm-ining GLP1R signaling bias.Trends Pharmacol Sci202642660721PubTator, text miningPubMed
Skeletal dysplasias of the parathyroid hormone signaling cascade: radiological manifestations and molecular mechanisms.Pediatr Radiol202642631736PubTator, text miningPubMed

1 to 10 of 2,698

See all 2,698 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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