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Gene · 57680

CHD8: chromodomain helicase DNA binding protein 8

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CHD8: chromodomain helicase DNA binding protein 8. Genes, record 57680. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/57680

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Gene

Symbol
CHD8
HGNC
Name
chromodomain helicase DNA binding protein 8
HGNC
NCBI Gene ID
57680
NCBI Gene
HGNC ID
HGNC:20153
HGNC
Ensembl
ENSG00000100888
NCBI Gene
Aliases
AUTS18, DUPLIN, HELSNF1, IDDAM, KIAA1564
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9HCK8ATP-dependent chromatin remodeler CHD82,5812Ensembl, GeneID, HGNC

Source UniProt

Patents20

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1441344Q9HCK8Espacenet
JP 2026004568 A2026-01-1441346Q9HCK8Espacenet
EP 4650780 A22025-11-1911695Q9HCK8Espacenet
EP 4641201 A22025-10-2912360Q9HCK8Espacenet
JP 2025517969 A2025-06-1212360Q9HCK8Espacenet
JP 2025517970 A2025-06-1211695Q9HCK8Espacenet
JP 2022141755 A2022-09-29304Q9HCK8Espacenet
US 11446398 B22022-09-2015289Q9HCK8Espacenet
US 11446398 B22022-09-2015295Q9HCK8Espacenet
JP 2022524081 A2022-04-27118260Q9HCK8Espacenet

1 to 10 of 20

See all 20 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,521

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCHD8 papersNewest fiscal year
R01MH101221Rare Mutations and Autism Spectrum Disorders402025
R25MH077823Research Education for Future Physician-Scientists in Child Psychiatry82025
T32HG000035Interdisciplinary Training in Genome Sciences82025
P30CA008748Cancer Center Support Grant62025
P30ES010126UNC Center for Environmental Health and Susceptibility62025
P50HD103525WASHINGTON UNIVERSITY INTELLECTUAL AND DEVELOPMENTAL DISABILITIES RESEARCH CENTER62025
T32HG002295Training in Bioinformatics and Integrative Genomics62025
P30CA016672Cancer Center Support Grant52025
P50HD103524Intellectual and Developmental Disabilities Research Center52025
R01GM121907Genomic basis of phenotypic variability of complex disorders52025

1 to 10 of 1,521Source NIH's project files

See all 1,521 nih grants

Papers1,441

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
CHD8-Dependent Chromatin Licensing Sustains Trophoblast Stem Cell Transcriptional Programs.Adv Sci (Weinh)202642801681PubTator, text miningPubMed
CRISPR-Enabled functional genomics in hPSCs-derived neural models for autism spectrum disorder.Metab Brain Dis202642747551PubTator, text miningPubMed
Whole-exome sequencing in individuals with obsessive-compulsive disorder and chronic tic disorders identifies 36 large-effect risk genes.Nat Neurosci202642680906PubTator, text miningPubMed
De novo chromatin remodelling variants in sporadic Chiari 1 malformation.Brain202642640505PubTator, text miningPubMed
An episignature informed systematic analysis to ascertain the clinical significance and consequences of CHD8 missense variants.Eur J Hum Genet202642575949PubTator, text miningPubMed
Advancements in the Understanding of the Genetics of Obsessive-Compulsive Disorder (OCD).Curr Psychiatry Rep202642536245PubTator, text miningPubMed
Genotypic and Phenotypic Profile of 50 Cases With Chromatin Remodeling Complexes-Related Neurological Disorders.CNS Neurosci Ther202642528014PubTator, text miningPubMed
Glial heterogeneity shapes region-specific angiogenesis and neurovascular integrity in the CNS.Sci Adv202642525738PubTator, text miningPubMed
Non-coding RNA dysregulation in autism spectrum disorder: Mechanisms, biomarkers, and therapeutic perspectives.Behav Brain Res202642480870PubTator, text miningPubMed
A Novel Variant of the CHD8 Gene in a Patient with Autism Spectrum Disorder.Genes (Basel)202642353758PubTator, text miningPubMed

1 to 10 of 1,441

See all 1,441 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/57680

GET https://conductscience.org/api/genes/v1/57680/patents