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BDKRB2: bradykinin receptor B2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. BDKRB2: bradykinin receptor B2. Genes, record 624. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/624

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Gene

Symbol
BDKRB2
HGNC
Name
bradykinin receptor B2
HGNC
NCBI Gene ID
624
NCBI Gene
HGNC ID
HGNC:1030
HGNC
Ensembl
ENSG00000168398
NCBI Gene
Aliases
B2R, BK-2, BK2, BKR2, BRB2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P30411B2 bradykinin receptor3916Ensembl, GeneID, HGNC

Source UniProt

Patents70

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026062654 A2026-04-1021P30411Espacenet
JP 2026004568 A2026-01-1439084P30411Espacenet
JP 2026004568 A2026-01-1439087P30411Espacenet
EP 4650780 A22025-11-1916652P30411Espacenet
EP 4641201 A22025-10-2920569P30411Espacenet
JP 2025529142 A2025-09-04574P30411Espacenet
US 12371689 B22025-07-29574P30411Espacenet
JP 2025517969 A2025-06-1220569P30411Espacenet
JP 2025517970 A2025-06-1216652P30411Espacenet
JP 2025062604 A2025-04-149409P30411Espacenet

1 to 10 of 70

See all 70 patents

Drugs6

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ANATIBANTCHEMBL2107725Bradykinin B2 receptor antagonistANTAGONISTChEMBL
FASITIBANTCHEMBL218427Bradykinin B2 receptor antagonistANTAGONISTChEMBL
FASITIBANT CHLORIDECHEMBL541758Bradykinin B2 receptor antagonistANTAGONISTChEMBL
ICATIBANTCHEMBL2028850Bradykinin B2 receptor antagonistANTAGONISTChEMBL
ICATIBANT ACETATECHEMBL2028852Bradykinin B2 receptor antagonistANTAGONISTChEMBL
LABRADIMILCHEMBL2105864Bradykinin B2 receptor agonistAGONISTChEMBL

Trials25

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT05509569ICATIBANTClinicalTrials.gov
NCT05407597ICATIBANTPHASE2/PHASE3ClinicalTrials.gov
NCT04978051ICATIBANTPHASE2ClinicalTrials.gov
NCT04654351ICATIBANTPHASE32022-03-29ClinicalTrials.gov
NCT04488081ICATIBANTPHASE2ClinicalTrials.gov
NCT04057131ICATIBANT ACETATE2025-02-21ClinicalTrials.gov
NCT03888755ICATIBANTPHASE32019-08-08ClinicalTrials.gov
NCT03177798ICATIBANTPHASE22019-10-29ClinicalTrials.gov
NCT03005184ICATIBANTPHASE2ClinicalTrials.gov
NCT02205814FASITIBANTPHASE22015-09-16ClinicalTrials.gov

1 to 10 of 25

See all 25 trials

NIH grants1,649

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleBDKRB2 papersNewest fiscal year
T32GM007569Clinical Pharmacology Training Program92025
P30CA008748Cancer Center Support Grant52025
R01DA008863Regulation Of Opioid Receptor Signaling by Endogenous Peptides52025
R01HL049277Animal Models for Studying the Genetics of Complex Diseases52025
P30CA068485Cancer Center Support Grant42025
P30DK036836Diabetes Research Center42025
P30CA046934University of Colorado Cancer Center Support Grant32025
P30ES013508Center of Excellence in Environmental Toxicology32025
P30EY008126Core Grant in Vision Research32025
P50HD027802Differential Diagnosis in Learning Disabilities32025

1 to 10 of 1,649Source NIH's project files

See all 1,649 nih grants

Papers3,739

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Mapping Pharmacogenomic Determinants of Adverse Drug Reactions in Hypertension: A Systematic Review.Pharmaceuticals (Basel)202642797533PubTator, text miningPubMed
Histopathological stratification of primary aldosteronism using the CYP11B2 size ratio: first evaluation in clinical routine.Histopathology202642549509PubTator, text miningPubMed
G protein signaling capabilities at the bradykinin 2 receptor.Naunyn Schmiedebergs Arch Pharmacol202642547588PubTator, text miningPubMed
Pharmacological Characterization of Vasomotor Responses in the Tree Shrew (Tupaia belangeri) Basilar Artery: A Promising Model for Human Cerebrovascular Research.Biology (Basel)202642510693PubTator, text miningPubMed
Overactivated bradykinin-B2 receptor promotes type a aortic dissection by inducing endothelial dysfunction: Therapeutic effect of icatibant.Life Sci202642413717PubTator, text miningPubMed
The bradykinin B2 receptor as a context-dependent modulator of neural circuit function.Front Cell Neurosci202642211761PubTator, text miningPubMed
Molecular mechanisms for subtype selectivity of kinin receptors' antagonists.Nat Commun202642185275PubTator, text miningPubMed
Can Scorpion Venom Peptides Be Safely Used in Cardiovascular Therapy: A Systematic Review.Cureus202642037951PubTator, text miningPubMed
An Immunomodulating Peptide With Potential to Counteract Endometriosis.Aust N Z J Obstet Gynaecol202641913689PubTator, text miningPubMed
The Gut Metabolite Phenylacetylglutamine Inhibits the Angiogenic Potential of Human Umbilical Vein Endothelial Cells Via the β-Adrenergic Receptor-LDHA Axis.J Cardiovasc Transl Res202641874920PubTator, text miningPubMed

1 to 10 of 3,739

See all 3,739 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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