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Gene · 6257

RXRB: retinoid X receptor beta

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. RXRB: retinoid X receptor beta. Genes, record 6257. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6257

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Gene

Symbol
RXRB
HGNC
Name
retinoid X receptor beta
HGNC
NCBI Gene ID
6257
NCBI Gene
HGNC ID
HGNC:10478
HGNC
Ensembl
ENSG00000204231
NCBI Gene
Aliases
DAUDI6, H-2RIIBP, NR2B2, RCoR-1, RXR-beta, RXRbeta
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P28702Retinoic acid receptor RXR-beta5337Ensembl, GeneID, HGNC

Source UniProt

Patents73

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1461536P28702Espacenet
JP 2026004568 A2026-01-1461539P28702Espacenet
JP 2026004568 A2026-01-1461541P28702Espacenet
JP 2026004568 A2026-01-1461543P28702Espacenet
JP 2026004568 A2026-01-1461546P28702Espacenet
JP 2026004568 A2026-01-1461547P28702Espacenet
EP 4650780 A22025-11-199502P28702Espacenet
JP 2025147176 A2025-10-0615593P28702Espacenet
JP 2025517970 A2025-06-129502P28702Espacenet
US 12280021 B22025-04-2265P28702Espacenet

1 to 10 of 73

See all 73 patents

Drugs6

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ACITRETINCHEMBL1131Retinoid receptor agonistAGONISTChEMBL
ALITRETINOINCHEMBL705Retinoid receptor agonistAGONISTChEMBL
BEXAROTENECHEMBL1023Retinoid X receptor agonistAGONISTChEMBL
ETRETINATECHEMBL464Retinoid receptor agonistAGONISTChEMBL
IRX-4204CHEMBL75133Retinoid X receptor agonistAGONISTChEMBL
MOFAROTENECHEMBL146506Retinoid receptor modulatorMODULATORChEMBL

Trials80

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT06739551ACITRETINPHASE2ClinicalTrials.gov
NCT06723171IRX-4204PHASE2ClinicalTrials.gov
NCT05401006ACITRETINPHASE4ClinicalTrials.gov
NCT05296304BEXAROTENEPHASE1ClinicalTrials.gov
NCT05259722ALITRETINOINPHASE32025-03-14ClinicalTrials.gov
NCT05203354ACITRETINPHASE4ClinicalTrials.gov
NCT05184348ACITRETINPHASE1ClinicalTrials.gov
NCT05106192BEXAROTENEClinicalTrials.gov
NCT04664829BEXAROTENEPHASE1ClinicalTrials.gov
NCT04537689ACITRETINPHASE4ClinicalTrials.gov

1 to 10 of 80

See all 80 trials

NIH grants925

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleRXRB papersNewest fiscal year
P30CA016672Cancer Center Support Grant102025
P30CA021765Cancer Center Support Grant (CCSG)52025
P30EY005722Center Core Grant for Vision Research42025
ZIACP010121Molecular Epidemiology Studies of Occupational and Environmental Exposures42025
P30CA016056Roswell Park Cancer Center Support Grant32025
P30CA016058Cancer Center Support Grant32025
P30CA016087Cancer Center Support Grant32025
R01EY012200Pax6 as a key regulator of lens development32025
P30AI168439Interdisciplinary NexGen TB research Advancement Center (IN-TRAC)22025
P30CA008748Cancer Center Support Grant22025

1 to 10 of 925Source NIH's project files

See all 925 nih grants

Papers1,309

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Retinoid X receptor in motion: Subtype-specific organization and dynamics of condensate-like assemblies.Int J Biol Macromol202642759629PubTator, text miningPubMed
Genome-wide CRISPR screens identify an RXR-MYLIP-LDLR axis regulating BH3 mimetic sensitivity in peripheral T-cell lymphomas.Oncogene202642642488PubTator, text miningPubMed
In Silico Multitarget Profiling of Betulinic Acid: ADME/Protox-II Toxicity, Network Pharmacology, and Molecular Docking for Diabetic Osteoporosis.Curr Drug Discov Technol202642634321PubTator, text miningPubMed
Integrative network toxicology and computational modeling uncover the mechanism of aflatoxin B1-induced nephrotoxicity.Ecotoxicol Environ Saf202642566874PubTator, text miningPubMed
Epigenetic Signatures of Frailty: A Systematic Review, Meta-Analysis, and Network Analysis of the Chemical Exposome.Int J Mol Sci202642450253PubTator, text miningPubMed
Monocytes from patients with chronic non-bacterial osteomyelitis (CNO) exhibit increased 'classically activated' phenotypes and altered DNA methylation patterns.Clin Immunol202642142821PubTator, text miningPubMed
From Gas Chromatography-Mass Spectrometry (GC-MS) to Network Pharmacology: System-Level Insights into the Multi-Target Biological Potential of Flaveria trinervia (Spreng.) C. Mohr.Curr Issues Mol Biol202641751423PubTator, text miningPubMed
Nutritional regulation of sow reproduction by vitamin A: insights and knowledge gaps.Porcine Health Manag202641715198PubTator, text miningPubMed
Investigating antidiabetic drug targets as potential therapeutic modulators for schizophrenia.Psychopharmacology (Berl)202641207901PubTator, text miningPubMed
Exploring the Therapeutic Potential of Antidiabetic Drugs in Cardiac Arrhythmia Management: A Drug Target Mendelian Randomization Study.J Arrhythm202541357784PubTator, text miningPubMed

1 to 10 of 1,309

See all 1,309 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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