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Gene · 6258

RXRG: retinoid X receptor gamma

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. RXRG: retinoid X receptor gamma. Genes, record 6258. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6258

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Gene

Symbol
RXRG
HGNC
Name
retinoid X receptor gamma
HGNC
NCBI Gene ID
6258
NCBI Gene
HGNC ID
HGNC:10479
HGNC
Ensembl
ENSG00000143171
NCBI Gene
Aliases
NR2B3, RXR-gamma, RXRC, RXRgamma
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P48443Retinoic acid receptor RXR-gamma4632Ensembl, GeneID, HGNC

Source UniProt

Patents57

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1461573P48443Espacenet
EP 4641201 A22025-10-297761P48443Espacenet
JP 2025147176 A2025-10-0615594P48443Espacenet
JP 2025517969 A2025-06-127761P48443Espacenet
JP 2025513058 A2025-04-227P48443Espacenet
US 12280021 B22025-04-2266P48443Espacenet
US 12269793 B22025-04-0866P48443Espacenet
JP 2025038035 A2025-03-184340P48443Espacenet
JP 2025028160 A2025-02-2815594P48443Espacenet
KR 1020250010750 A2025-01-2115594P48443Espacenet

1 to 10 of 57

See all 57 patents

Drugs6

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ACITRETINCHEMBL1131Retinoid receptor agonistAGONISTChEMBL
ALITRETINOINCHEMBL705Retinoid receptor agonistAGONISTChEMBL
BEXAROTENECHEMBL1023Retinoid X receptor agonistAGONISTChEMBL
ETRETINATECHEMBL464Retinoid receptor agonistAGONISTChEMBL
IRX-4204CHEMBL75133Retinoid X receptor agonistAGONISTChEMBL
MOFAROTENECHEMBL146506Retinoid receptor modulatorMODULATORChEMBL

Trials80

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT06739551ACITRETINPHASE2ClinicalTrials.gov
NCT06723171IRX-4204PHASE2ClinicalTrials.gov
NCT05401006ACITRETINPHASE4ClinicalTrials.gov
NCT05296304BEXAROTENEPHASE1ClinicalTrials.gov
NCT05259722ALITRETINOINPHASE32025-03-14ClinicalTrials.gov
NCT05203354ACITRETINPHASE4ClinicalTrials.gov
NCT05184348ACITRETINPHASE1ClinicalTrials.gov
NCT05106192BEXAROTENEClinicalTrials.gov
NCT04664829BEXAROTENEPHASE1ClinicalTrials.gov
NCT04537689ACITRETINPHASE4ClinicalTrials.gov

1 to 10 of 80

See all 80 trials

NIH grants813

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleRXRG papersNewest fiscal year
P30CA008748Cancer Center Support Grant32025
P30CA091842Cancer Center Support Grant32025
R01CA137124Production and progression of premalignant retinoblastoma lesions.32025
R01HL086694From GWAS loci to blood pressure genes, variants & mechanisms - Renewal32025
P30CA016672Cancer Center Support Grant22025
P30CA060553The Robert H. Lurie Comprehensive Cancer Center22025
P30CA068485Cancer Center Support Grant22025
P30ES019776HERCULES: Exposome Research Center22025
P30EY008126Core Grant in Vision Research22025
P50CA171963Specialized Program of Research Excellence (SPORE) in Leukemia22025

1 to 10 of 813Source NIH's project files

See all 813 nih grants

Papers895

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
In Silico Multitarget Profiling of Betulinic Acid: ADME/Protox-II Toxicity, Network Pharmacology, and Molecular Docking for Diabetic Osteoporosis.Curr Drug Discov Technol202642634321PubTator, text miningPubMed
Integrative single-nucleus transcriptomic analysis identifies UBE2C+ proliferative tumor cells and immune-stromal regulatory crosstalk in small cell lung cancer.Front Immunol202642614523PubTator, text miningPubMed
Psoralen enhances direct cardiac reprogramming via activating PPARα and driving mitochondrial fission and improves cardiac function after myocardial infarction.Stem Cell Res Ther202642421106PubTator, text miningPubMed
Liver endothelial zonation orchestrates hepatic steatosis onset through retinoic acid-regulated FGF1.Sci Adv202642319926PubTator, text miningPubMed
Quadruple immunotherapy with allogeneic natural killer cell infusion for recurrent neuroblastoma.Cytotherapy202642202757PubTator, text miningPubMed
Towards a unified molecular mechanism for ligand-dependent activation of NR4A-RXR heterodimers.Elife202642059885PubTator, text miningPubMed
Epigenetic dichotomy in florid vs. gliotic proliferative diabetic retinopathy: hypomethylation of EGLN1 and MMP9 drives divergent pathogenic pathways in angiogenesis and fibrosis.Front Endocrinol (Lausanne)202641958874PubTator, text miningPubMed
RXR Gamma Enables Oligodendrocyte Differentiation by Suppressing Sonic Hedgehog Signaling.Glia202641934103PubTator, text miningPubMed
Copper deficiency impairs oligodendrocyte maturation and social behavior via mitophagy and mTOR suppression in ASD.Sci Adv202641920999PubTator, text miningPubMed
Deciphering the cardiac neuron landscape in heart failure patients.PLoS Comput Biol202641860822PubTator, text miningPubMed

1 to 10 of 895

See all 895 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/6258

GET https://conductscience.org/api/genes/v1/6258/patents?page=2