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Gene · 6263

RYR3: ryanodine receptor 3

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. RYR3: ryanodine receptor 3. Genes, record 6263. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6263

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Gene

Symbol
RYR3
HGNC
Name
ryanodine receptor 3
HGNC
NCBI Gene ID
6263
NCBI Gene
HGNC ID
HGNC:10485
HGNC
Ensembl
ENSG00000198838
NCBI Gene
Aliases
CMYO20, CMYP20, RYR-3
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q15413Ryanodine receptor 34,87010Ensembl, GeneID, HGNC

Source UniProt

Patents21

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1462520Q15413Espacenet
EP 4641201 A22025-10-2923913Q15413Espacenet
JP 2025529142 A2025-09-043808Q15413Espacenet
US 12371689 B22025-07-293808Q15413Espacenet
JP 2025517969 A2025-06-1223913Q15413Espacenet
JP 2025032204 A2025-03-1135183Q15413Espacenet
EP 4461818 A22024-11-1335183Q15413Espacenet
JP 2023058610 A2023-04-2535183Q15413Espacenet
JP 2022141755 A2022-09-29316Q15413Espacenet
US 11446398 B22022-09-2076243Q15413Espacenet

1 to 10 of 21

See all 21 patents

Drugs2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
DANTROLENECHEMBL1201288Ryanodine receptor 3 antagonistANTAGONISTChEMBL
DANTROLENE SODIUMCHEMBL928Ryanodine receptor 3 antagonistANTAGONISTChEMBL

Trials10

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT06966843DANTROLENEPHASE2/PHASE3ClinicalTrials.gov
NCT04134845DANTROLENEPHASE2/PHASE32025-08-15ClinicalTrials.gov
NCT03600376DANTROLENE SODIUMPHASE32021-04-26ClinicalTrials.gov
NCT03109288DANTROLENEPHASE1/PHASE2ClinicalTrials.gov
NCT02829268DANTROLENE SODIUMPHASE1/PHASE22024-03-13ClinicalTrials.gov
NCT02513095DANTROLENE SODIUMPHASE22017-05-09ClinicalTrials.gov
NCT01950520DANTROLENEPHASE22024-10-16ClinicalTrials.gov
NCT01024972DANTROLENEPHASE1/PHASE22015-03-05ClinicalTrials.gov
NCT00964548DANTROLENEPHASE1/PHASE22012-05-25ClinicalTrials.gov
NCT00796900DANTROLENEPHASE2/PHASE3ClinicalTrials.gov

NIH grants1,117

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleRYR3 papersNewest fiscal year
R01ES014901Molecular and Cellular Basis of PCB Developmental Neurotoxicity82025
R01HL140934Exploring the Molecular Physiology of Atrial Fibrillation72025
P30DK063491Diabetes Research Center (DRC)52025
P30CA016672Cancer Center Support Grant42025
R25NS076445Summer Program for Undergraduate Rising Stars (SPURS), a Columbia University biomedical sciences pipeline program42025
P30ES005605Environmental Health Sciences Research Center32025
P30ES023513UC Davis Environmental Health Sciences Core Center32025
P50AA022537Cross-species investigation of gene networks for ethanol-related behaviors32025
T32ES007059Advanced Training in Environmental Health Sciences32025
UL1TR001863Yale Clinical and Translational Science Award32025

1 to 10 of 1,117Source NIH's project files

See all 1,117 nih grants

Papers1,086

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Cross-Species Transcriptomic Integration Identifies a Conserved Molecular Core and Regulatory ceRNA Network in Duchenne Muscular Dystrophy.Genes (Basel)202642792910PubTator, text miningPubMed
Deciphering the impact of genetic variants on vulnerability to Opioid Use Disorder.Front Cell Neurosci202642787119PubTator, text miningPubMed
Integrated RNA-seq and ATAC-seq analyses reveal muscle development differences between european meat pigeon and shiqi pigeon during embryonic to post-hatching stages.Front Cell Dev Biol202642780728PubTator, text miningPubMed
SHBG and APOA1 as serum biomarkers for low bone mineral density in Mexican postmenopausal women: a random forest-based analysis.Front Endocrinol (Lausanne)202642620835PubTator, text miningPubMed
The First Iranian Patient with West Syndrome Due to a RYR3 Gene Variant: A Case Report and Literature Review.Arch Iran Med202642604421PubTator, text miningPubMed
Serum proteomic signatures and an immune-calcium signaling cascade associated with antipsychotic-related erectile dysfunction in schizophrenia.Sci Rep202642178376PubTator, text miningPubMed
Expanding the genetic spectrum of neurogenetic disorders in moroccan families by exome sequencing: identification of candidate variants in RYR3, POLR3A, and LAMA2.Mol Biol Rep202642113100PubTator, text miningPubMed
The mutational and transcriptional status of RYR in CRC and its indication for prognosis.Arab J Gastroenterol202642031610PubTator, text miningPubMed
Single-Nucleus RNA Sequencing Reveals Muscle Fiber Cell Heterogeneity During Human Skeletal Muscle Aging.Aging Cell202641979358PubTator, text miningPubMed
Distinct mutational signature and clonal evolution in constitutional mismatch repair deficiency-associated high-grade gliomas.iScience202641797895PubTator, text miningPubMed

1 to 10 of 1,086

See all 1,086 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/6263

GET https://conductscience.org/api/genes/v1/6263/patents?page=2