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Gene · 6326

SCN2A: sodium voltage-gated channel alpha subunit 2

11 sourcesgene-search-2026-11-11-0.1.0

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ConductScience Library. SCN2A: sodium voltage-gated channel alpha subunit 2. Genes, record 6326. Release gene-search-2026-11-11-0.1.0, 11 Nov 2026. https://conductscience.org/library/genes/6326

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Gene

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

Symbol
SCN2A
HGNC
Name
sodium voltage-gated channel alpha subunit 2
HGNC
NCBI Gene ID
6326
NCBI Gene
HGNC ID
HGNC:10588
HGNC
Ensembl
ENSG00000136531
NCBI Gene
Aliases
BFIC3, BFIS3, BFNIS, DEE11, EA9, EIEE11, HBA, HBSCI, HBSCII, NAC2, Na(v)1.2, Nav1.2, SCN2A1, SCN2A2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q99250Sodium channel protein type 2 subunit alpha2,0055Ensembl, GeneID, HGNC

Source UniProt

Patents71

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
US 12630827 B22026-05-1911Q99250Espacenet
US 12618072 B22026-05-051Q99250Espacenet
US 12618072 B22026-05-058Q99250Espacenet
JP 2026004568 A2026-01-1463889Q99250Espacenet
JP 2026004568 A2026-01-1463892Q99250Espacenet
EP 4640849 A22025-10-29394Q99250Espacenet
EP 4641201 A22025-10-292766Q99250Espacenet
JP 2025529142 A2025-09-043842Q99250Espacenet
US 12371689 B22025-07-293842Q99250Espacenet
JP 2025519096 A2025-06-24394Q99250Espacenet

1 to 10 of 71

See all 71 patents

Drugs84

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ARTICAINECHEMBL1093Sodium channel alpha subunit blockerBLOCKERChEMBL
ARTICAINE HYDROCHLORIDECHEMBL1200819Sodium channel alpha subunit blockerBLOCKERChEMBL
BENOXINATECHEMBL1200Sodium channel alpha subunit blockerBLOCKERChEMBL
BENOXINATE HYDROCHLORIDECHEMBL1200654Sodium channel alpha subunit blockerBLOCKERChEMBL
CARBAMAZEPINECHEMBL108Sodium channel alpha subunit blockerBLOCKERChEMBL
CENOBAMATECHEMBL3989949Sodium channel alpha subunit inhibitorINHIBITORChEMBL
CHLOROPROCAINECHEMBL1179047Sodium channel alpha subunit blockerBLOCKERChEMBL
CHLOROPROCAINE HYDROCHLORIDECHEMBL944Sodium channel alpha subunit blockerBLOCKERChEMBL
COCAINECHEMBL370805Sodium channel alpha subunit blockerBLOCKERChEMBL
COCAINE HYDROCHLORIDECHEMBL529437Sodium channel alpha subunit blockerBLOCKERChEMBL

1 to 10 of 84

See all 84 drugs

Trials1,301

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

NIH grants2,208

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal year
R01NS034509Functional Genetics of the Neuronal Sodium Channel Gene SCN8A262025
R01MH101221Rare Mutations and Autism Spectrum Disorders252025
R01NS117585Neuronal and Behavioral Deficits Associated with Scn2a Deficiency in Autism Spectrum Disorder92025
R01NS123154Neuronal hyperexcitability and seizures in a Scn2a deficient mouse model92025
U24NS120854ClinGen Expert Curation Panel for the Epilepsies92025
UL1TR001878Institutional Clinical and Translational Science Award92025
T32HG000035Interdisciplinary Training in Genome Sciences82025
R01MH125978The function of SCN2A in neocortex72025
P30CA016059Massey Cancer Center - Cancer Center Support Grant62025
P50HD105351Boston Children's Hospital/HMS Intellectual and Developmental Disabilities Research Center62025

1 to 10 of 2,208Source NIH's project files

See all 2,208 nih grants

Papers4,098

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42818077PubTator, text miningPubMed
42815470PubTator, text miningPubMed
42774767PubTator, text miningPubMed
42768401PubTator, text miningPubMed
42762592PubTator, text miningPubMed
42758957PubTator, text miningPubMed
42751217PubTator, text miningPubMed
42747551PubTator, text miningPubMed
42745013PubTator, text miningPubMed
42742013PubTator, text miningPubMed

1 to 10 of 4,098

See all 4,098 papers

Sources 11

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNone stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GeneNone named. Public domain as US government information
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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